All experiments were conducted in accordance with the NIH Guidelines for the Care and Use of Laboratory Animals and were approved by the institutional Animal Care and Use Committee of the Veteran’s Administration Portland Health Care System (VAPORHCS), under IACUC protocols 3783–20 and 3041–20 (PI- Quinn). 5XFAD and B6SJLF1 mice were purchased from JAX (The Jackson Laboratory, Bar Harbor, ME). 5XFAD mice overexpress human Amyloid Precursor Protein (APP) with three familial Alzheimer’s disease (FAD) mutations [the Swedish (K670N, M671L), Florida (I716V), and London (V7171) mutations] and human PSEN1 with two FAD mutations (M146L and L286V). The mouse colony was maintained by breeding 5XFAD positive male mice with B6SJLF1 females. Wild type littermates were used as controls for each experiment. Animal numbers for each sex and genotype used in this study are summarized in Fig. 1A . All treatment cohorts included both male and female mice, evaluated independently.
5xfad and b6sjlf1 mice
Manufactured by Jackson ImmunoResearch
Sourced in Montenegro
5XFAD and B6SJLF1 mice are laboratory animal models used in research. The 5XFAD mouse model is commonly used to study Alzheimer's disease, while the B6SJLF1 mouse is a hybrid strain used as a control in various studies. These mice are bred and distributed by Jackson ImmunoResearch for use in scientific research applications.
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Lab products found in correlation
2 protocols using 5xfad and b6sjlf1 mice
1
Alzheimer's Disease Transgenic Mice Protocol
2
Alzheimer's Disease Transgenic Mice Protocol
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All experiments were conducted in accordance with the NIH Guidelines for the Care and Use of Laboratory Animals and were approved by the institutional Animal Care and Use Committee of the Veteran’s Administration Portland Health Care System (VAPORHCS), under IACUC protocols 3783–20 and 3041–20 (PI- Quinn). 5XFAD and B6SJLF1 mice were purchased from JAX (The Jackson Laboratory, Bar Harbor, ME). 5XFAD mice overexpress human Amyloid Precursor Protein (APP) with three familial Alzheimer’s disease (FAD) mutations [the Swedish (K670N, M671L), Florida (I716V), and London (V7171) mutations] and human PSEN1 with two FAD mutations (M146L and L286V). The mouse colony was maintained by breeding 5XFAD positive male mice with B6SJLF1 females. Wild type littermates were used as controls for each experiment. Animal numbers for each sex and genotype used in this study are summarized in Fig. 1A . All treatment cohorts included both male and female mice, evaluated independently.
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