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On target plus sirna targeting brca1

Manufactured by Horizon Discovery
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ON-TARGET Plus siRNA targeting BRCA1 is a small interfering RNA (siRNA) product designed to target the BRCA1 gene. It is intended for use in RNA interference (RNAi) experiments to study the function of the BRCA1 gene.

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Lab products found in correlation

Dharmafect 2, by Horizon Discovery (2 mentions) Brca2, by Horizon Discovery (2 mentions) Rad51, by Horizon Discovery (2 mentions) On target plus sirna non targeting control, by Horizon Discovery (2 mentions)

Spelling variants of this product

SiRNAs (161 citations) ON-TARGET (46 citations) SiRNA targeting (10 citations) BRCA1 (5 citations) BRCA1 siRNAs (3 citations)

2 protocols using on target plus sirna targeting brca1

1

Targeted siRNA Knockdown Assays

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siRNA transfections were carried out with Dharmafect 2 (GE Dharmacon) per manufacturers protocol with final siRNA concentration at 20 nM for all assays. siRNAs used were ON-TARGET Plus siRNA targeting BRCA1 (GE Dharmacon, L-003461), RAD51 (GE Dharmacon, L-003530), BRCA2(L-003462, GE Dharmacon), SDHB (GE Dharmacon, L-011773), FH (L-009512, GE Dharmacon) and the ON-TARGET Plus siRNA non-targeting control (GE Dharmacon, D-001810)
Sulkowski P.L., Sundaram R.K., Oeck S., Corso C.D., Liu Y., Noorbakhsh S., Niger M., Boeke M., Ueno D., Kalathil A.N., Bao X., Li J., Shuch B., Bindra R.S, & Glazer P.M. (2018). Krebs Cycle-Deficient Hereditary Cancer Syndromes are Defined by Homologous Recombination DNA Repair Defects. Nature genetics, 50(8), 1086-1092.
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2

Targeted siRNA Knockdown Assays

Check if the same lab product or an alternative is used in the 5 most similar protocols
siRNA transfections were carried out with Dharmafect 2 (GE Dharmacon) per manufacturers protocol with final siRNA concentration at 20 nM for all assays. siRNAs used were ON-TARGET Plus siRNA targeting BRCA1 (GE Dharmacon, L-003461), RAD51 (GE Dharmacon, L-003530), BRCA2(L-003462, GE Dharmacon), SDHB (GE Dharmacon, L-011773), FH (L-009512, GE Dharmacon) and the ON-TARGET Plus siRNA non-targeting control (GE Dharmacon, D-001810)
Sulkowski P.L., Sundaram R.K., Oeck S., Corso C.D., Liu Y., Noorbakhsh S., Niger M., Boeke M., Ueno D., Kalathil A.N., Bao X., Li J., Shuch B., Bindra R.S, & Glazer P.M. (2018). Krebs Cycle-Deficient Hereditary Cancer Syndromes are Defined by Homologous Recombination DNA Repair Defects. Nature genetics, 50(8), 1086-1092.
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