Ritonavir (purity >99.8%) was obtained from AbbVie Inc. (North Chicago, US). Copovidone (polyvinylpyrrolidone–vinyl acetate copolymer, Kollidon® VA 64) was purchased from BASF SE (Ludwigshafen, Germany), fumed silicon dioxide (Aerosil® 200) from Evonik Industries (Essen, Germany), sorbitan monolaurate (Span® 20) from CRODA (Nettetal, Germany), dicalcium phosphate anhydrous (DI-CAFOS® A60) from Chemische Fabrik Budenheim (Budenheim, Germany), and sodium stearyl fumarate (PRUV®) from JRS Pharma (Rosenberg, Germany). Acetone (Emprove® Essential, purity 96%) and methanol (Emprove® Essential, purity 99.5%) were obtained from Merck KGaA (Darmstadt, Germany).
Span 20
Manufactured by Croda
Sourced in Germany, United Kingdom
Span® 20 is a non-ionic surfactant. It is a product of Croda, a leading specialty chemicals company. Span® 20 is primarily used as an emulsifier, solubilizer, and wetting agent in various industrial and personal care applications.
Automatically generated - may contain errors
Lab products found in correlation
Emprove essential, by Merck Group (1 mentions)
Kollidon va64, by BASF (1 mentions)
Aerosil 200, by Evonik (1 mentions)
Ritonavir, by Abbvie (1 mentions)
Caco 2 cell line, by American Type Culture Collection (1 mentions)
Eagle s minimum essential medium emem, by American Type Culture Collection (1 mentions)
Transwell polycarbonate membrane cell culture insert, by Corning (1 mentions)
Fetal bovine serum (fbs), by American Type Culture Collection (1 mentions)
Amphotericin b, by Merck Group (1 mentions)
Penicillin streptomycin, by Merck Group (1 mentions)
Acetonitrile, by Merck Group (1 mentions)
Potassium chloride (kcl), by Merck Group (1 mentions)
Sodium chloride (nacl), by Merck Group (1 mentions)
Sodium phosphate dibasic dihydrate, by Merck Group (1 mentions)
Phosphate buffered saline (pbs), by Merck Group (1 mentions)
Potassium phosphate monobasic, by Merck Group (1 mentions)
2 protocols using span 20
1
Formulation Development of Ritonavir Tablets
2
Valsartan Dissolution Studies in Caco-2 Cells
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Valsartan was supplied by Polpharma (Starogard, Gdański,
Poland). Hydroxypropyl methylcellulose (HPMC) from Lotte Fine Chemicals
(Nam-gu, Ulsan, South Korea) and lactose monohydrate from DFE Pharma
(Goch, Germany) were also supplied by Polpharma. Span 20 was acquired
from Croda (Snaith, United Kingdom). Ethanol 96% (Ph. Eur.) was purchased
from Panreac (Castellar del Vallès, Spain). Caco-2 cell line,
Eagle’s minimum essential medium (EMEM), fetal bovine serum
(FBS), Hank’s balanced salt solution (HBSS), and trypsin–ethylenediaminetetraacetic
acid (EDTA) solution were purchased from ATCC (Manassas, VA). Penicillin–streptomycin,
amphotericin B, phosphate-buffered saline (PBS), hydroclorothiazide,
acetonitrile, sodium chloride, potassium chloride, sodium phosphate
dibasic dihydrate, and potassium phosphate monobasic were purchased
from Sigma-Aldrich (St. Louis, MO). A N-(2-hydroxyethyl)piperazine-N′-ethanesulfonic acid (HEPES) solution was purchased
from Biowest (Nuaillé, France) and Corning Transwell polycarbonate
membrane cell culture inserts were purchased from Corning (Corning,
NY). Size 9 gelatin capsules (8.4 mm × 2.7 mm) were purchased
from Torpac (Fairfield, NJ). Polyurethane #9 capsule dosers were purchased
from Instech (Plymouth Meeting, PA). Deionized water was used throughout
the study.
Poland). Hydroxypropyl methylcellulose (HPMC) from Lotte Fine Chemicals
(Nam-gu, Ulsan, South Korea) and lactose monohydrate from DFE Pharma
(Goch, Germany) were also supplied by Polpharma. Span 20 was acquired
from Croda (Snaith, United Kingdom). Ethanol 96% (Ph. Eur.) was purchased
from Panreac (Castellar del Vallès, Spain). Caco-2 cell line,
Eagle’s minimum essential medium (EMEM), fetal bovine serum
(FBS), Hank’s balanced salt solution (HBSS), and trypsin–ethylenediaminetetraacetic
acid (EDTA) solution were purchased from ATCC (Manassas, VA). Penicillin–streptomycin,
amphotericin B, phosphate-buffered saline (PBS), hydroclorothiazide,
acetonitrile, sodium chloride, potassium chloride, sodium phosphate
dibasic dihydrate, and potassium phosphate monobasic were purchased
from Sigma-Aldrich (St. Louis, MO). A N-(2-hydroxyethyl)piperazine-N′-ethanesulfonic acid (HEPES) solution was purchased
from Biowest (Nuaillé, France) and Corning Transwell polycarbonate
membrane cell culture inserts were purchased from Corning (Corning,
NY). Size 9 gelatin capsules (8.4 mm × 2.7 mm) were purchased
from Torpac (Fairfield, NJ). Polyurethane #9 capsule dosers were purchased
from Instech (Plymouth Meeting, PA). Deionized water was used throughout
the study.
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