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Bexarotene

Manufactured by Thermo Fisher Scientific
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Bexarotene is a laboratory reagent used for scientific research. It is a synthetic retinoid compound. Bexarotene is primarily used in cell culture and biochemical applications as a research tool.

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Lab products found in correlation

Dexamethasone (dex), by Merck Group (1 mentions) Rosiglitazone, by Thermo Fisher Scientific (1 mentions) Retrovirus prdm16, by Addgene (1 mentions) Prdm16 shrna, by Addgene (1 mentions)

2 protocols using bexarotene

1

Compound Acquisition and Preparation

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PonA was obtained from Agilent Technologies Inc./Invitrogen. Dexamethasone, prednisolone, E2, EE2 and 4OHT were obtained from MilliporeSigma. Bexarotene was obtained from Thermo Scientific. RU-486 was obtained from Torcis Bioscience. Stock solutions in ethanol were prepared for all compounds at 100x of their final assay concentrations.
Kretschmer S., Perry N., Zhang Y, & Kortemme T. (2023). Multi-input drug-controlled switches of mammalian gene expression based on engineered nuclear hormone receptors. bioRxiv.
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2

RXR Isoform Overexpression and Knockdown

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The mouse RXRα and RXRγ plasmids were from Dr. Ronald Evans (Salk Institute), and the mouse RXRβ plasmid was purchased from OriGene. These three RXR fragments were subcloned into the pMXs retrovirus construct (Yamanaka lab, Gladstone Institutes) via the EcoRI site. All constructs were sequenced for verification. Nontarget shRNA(shNT), shRXRα, shRXRβ, and shRXRγ lentivirus constructs were purchased from Sigma-Aldrich. Retrovirus PRDM16 (plasmid 15504) and PRDM16 shRNA (plasmid 15505) constructs were purchased from Addgene. Retrovirus and lentivirus constructs were packaged in Plat E and 293T cells, respectively. Bexarotene, HX531, and rosiglitazone were purchased from Thermo Fisher Scientific, Tocris Bioscience, and Sigma-Aldrich, respectively.
Nie B., Nie T., Hui X., Gu P., Mao L., Li K., Yuan R., Zheng J., Wang H., Li K., Tang S., Zhang Y., Xu T., Xu A., Wu D, & Ding S. (2017). Brown Adipogenic Reprogramming Induced by a Small Molecule. Cell reports, 18(3).
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