The 6-OHDA was purchased from Sigma-Aldrich (St. Louis, MO, USA). D-amphetamine was provided by the NIDA Drug Supply Program. GW842166X and AM630 were purchased from Cayman Chemical Company (Ann Arbor, MI, USA). GW842166X and AM630 were first dissolved in DMSO (Sigma-Aldrich) and then mixed with TWEEN-80 (Sigma-Aldrich). Then, sterile saline was added to the mix solution to create a final working solution with 2.5% DMSO + 2.5% TWEEN-80 + 95% saline. Picrotoxin and all other common chemicals were obtained from Sigma-Aldrich. 6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt (CNQX) and D-(-)-2-Amino-5-phosphonopentanoic acid (D-AP5) were obtained from Tocris Bioscience (Ellisville, MO, USA).
6 cyano 7 nitroquinoxaline 2 3 dione disodium salt cnqx
Manufactured by Bio-Techne
Sourced in United States
6-cyano-7-nitroquinoxaline-2,3-dione disodium salt (CNQX) is a selective non-NMDA glutamate receptor antagonist. It functions as a blocker of AMPA and kainate receptors.
Automatically generated - may contain errors
Lab products found in correlation
Bicuculline methiodide, by Bio-Techne (2 mentions)
Tetrodotoxin citrate ttx, by Bio-Techne (2 mentions)
Polyinosinic polycytidylic acid, by Merck Group (2 mentions)
D 2 amino 5 phosphonopentanoic acid ap5, by Bio-Techne (2 mentions)
Picrotoxin, by Merck Group (1 mentions)
Am630, by Merck Group (1 mentions)
Gw842166x, by Cayman Chemical (1 mentions)
Gw842166x, by Merck Group (1 mentions)
D 2 amino 5 phosphonopentanoic acid d ap5, by Bio-Techne (1 mentions)
6 ohda, by Merck Group (1 mentions)
Am630, by Cayman Chemical (1 mentions)
Dimethyl sulfoxide (dmso), by Merck Group (1 mentions)
Tween 80, by Merck Group (1 mentions)
3 protocols using 6 cyano 7 nitroquinoxaline 2 3 dione disodium salt cnqx
1
6-OHDA-Induced Neurodegeneration Model
2
Poly IC Exposure in Pregnant Dams
Check if the same lab product or an alternative is used in the 5 most similar protocols
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Polyinosinic-Polycytidylic acid (Poly IC; Sigma-Aldrich; P9582) was prepared as a stock solution of 0.5 mg/mL (calculated based on the weight of Poly IC alone). Pregnant dams bearing embryos received either an intravenous injection of 1 mg/kg Poly IC or vehicle (physiological Saline) solution on embryonic day 9 (E9). For electrophysiology, 20 μM 6-cyano-7-nitroquinoxaline-2,3-dione disodium salt (CNQX, Tocris Bioscience), 50 μM D-(-)-2-Amino-5-phosphonopentanoic acid (AP5, Tocris Bioscience), 2 μM tetrodotoxin citrate (TTX, Tocris Bioscience) and 10 μM (-)-bicuculline methiodide (Tocris Bioscience) were added to the perfusate where noted.
3
Poly IC Exposure in Pregnant Dams
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