Trio scanner

Our fMRI data comes from a large (N=314; 231 male (M), 83 female (F)) multisite study, balanced between schizophrenia patients (151 SZ) and healthy controls (163 HC) [9 ]. The subjects were instructed to keep their eyes closed during the scan and were not engaged in any specified task. The ages of participants ranged between 18 and 60 (mean 37.9). Informed consent was obtained from all subjects according to the institutional guidelines the seven participating data collection sites. Imaging from six of the sites was performed on a 3T Siemens Trio scanner; the seventh site used a 3T GE MR750. A total of 162 volumes of resting fMRI data was acquired for each subject using a gradient-echo planar imaging paradigm: FOV of 220×220 mm (64×64 matrix), TR=2 s TE = 30 ms, flip angle = 77°, slice thickness = 4 mm, slice gap = 1 mm, voxel size = 3 mm³. A combination of toolboxes (AFNI1, SPM2, GIFT3) and custom code written in Matlab was employed in the pre-processing pipeline. Rigid body motion correction was performed with the INRIAlign toolbox in SPM to correct for subject head motion, followed by slice-timing correction to account for timing differences in slice acquisition. Additional details can be found in [9 ].

Subjects at the UCLA and Stanford sites undergo neuroimaging scans at baseline and at 4 months (the length of the psychosocial treatment interval) (at the inception of the study, neuroimaging was not available at the Colorado site). The one-hr. scan session includes two functional MRI (fMRI) scans and a high-resolution T1-weighted anatomical scan. YMRS and CDRS-R ratings are obtained within one week of each scan. FMRI data are collected at UCLA in the Center for Cognitive Neuroscience on a 3.0T Siemens Trio scanner, and at Stanford on a 3T GE Signa scanner. Both sites used an 8 channel head coil and an echoplanar pulse sequence with the following parameters: TR = 2000 ms, TE = 30 ms, flip angle = 80 degrees; 30 axial slices, 4mm thick, .05 mm skip, field of view = 22 cm, 64x64 matrix, inplane spatial resolution = 3.4275. Scan parameters are optimized for comparability across sites. Participants perform two tasks during the scan.