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Jte 013

Manufactured by Selleck Chemicals
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Sourced in United States

JTE 013 is a chemical compound used as a laboratory reagent. It functions as a selective antagonist for the sphingosine 1-phosphate receptor subtype 2 (S1P2).

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Lab products found in correlation

Siponimod, by Selleck Chemicals (1 mentions) Fty720, by MedChemExpress (1 mentions) Pf 543, by Selleck Chemicals (1 mentions) Opaganib, by Selleck Chemicals (1 mentions) Nct 503, by MedChemExpress (1 mentions) Cell counting kit 8 ck04, by Dojindo Laboratories (1 mentions) Matrigel, by Corning (1 mentions) Transwell chamber, by Corning (1 mentions) Vpc23019, by Cayman Chemical (1 mentions) 6 well cell culture dishes, by Corning (1 mentions) Transforming growth factor β tgf β, by R&D Systems (1 mentions)

3 protocols using jte 013

1

Small Molecule Compound Acquisition Protocol

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PF-543 (S7177), Opaganib (S7174), Siponimod (S7179) and JTE 013 (S7182) were purchased from Selleck. NCT-503 (HY-101966), FTY-720 (HY-12005) and SK-IN-1 (HY-101805) were purchased from MedChemExpress. NAAG (A5930) was purchased from Sigma.
Xiao Y., Ma D., Yang Y.S., Yang F., Ding J.H., Gong Y., Jiang L., Ge L.P., Wu S.Y., Yu Q., Zhang Q., Bertucci F., Sun Q., Hu X., Li D.Q., Shao Z.M, & Jiang Y.Z. (2022). Comprehensive metabolomics expands precision medicine for triple-negative breast cancer. Cell Research, 32(5), 477-490.
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2

Investigating S1PR2 Signaling in Cancer Metastasis

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Primary antibodies directed against S1PR2 (sc-365589), p-p65 (Ser536) (Sc-136548) were obtained from Santa Cruz Biotechnology (California, USA). Antibodies for detecting p65 (8242) were purchased from Cell Signaling Biotechnology (Massachusetts, USA). The anti-MMP9 antibody (10375-2-AP) was obtained from Proteintech (Shanghai, China). JTE-013 was purchased from Selleck (Houston, USA). The cell counting kit-8 (CCK8) (CK04) was purchased from DOJINDO (Kyushu, Japan). Transwell chamber and Matrigel were obtained from CORNING (California, USA).
Pang M., Li C., Zheng D., Wang Y., Wang J., Zhang W., Li F, & Jing H. (2020). S1PR2 Knockdown Promotes Migration and Invasion in Multiple Myeloma Cells via NF-κB Activation. Cancer Management and Research, 12, 7857-7865.
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3

Exogenous S100A4 Regulation of Cell Culture

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Cells from cell lines or freshly isolated cells (2 × 105) were cultured in 6-well cell culture dishes (Corning, NY, USA) and RPMI-1640 supplemented with 10% fetal bovine serum, 100 U/ml penicillin, and 100 µg/ml streptomycin. Recombinant exogenous S100A4 was added as indicated. If applicable, S100A4 was preincubated with a twofold molar excess of anti-S100A4 for 30 min at 4°C. S1P function was altered by using the S1P1/S1P3 antagonist VPC23019 (Cayman, Ann Arbor, MI, USA), S1P2 antagonist JTE013 (Selleck, Shanghai, China), transforming growth factor-β (TGF-β) was purchased from R&D Systems (Minneapolis, MN, USA).
Li Y., Bao J., Bian Y., Erben U., Wang P., Song K., Liu S., Li Z., Gao Z, & Qin Z. (2018). S100A4+ Macrophages Are Necessary for Pulmonary Fibrosis by Activating Lung Fibroblasts. Frontiers in Immunology, 9, 1776.
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