Ketamine hcl

Manufactured by Vedco

Sourced in United States

Ketamine HCl is a chemical compound that serves as a general anesthetic and analgesic. It is commonly used in veterinary medicine and research applications. The product provides a reliable and consistent formula to meet the needs of medical and scientific professionals.

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Lab products found in correlation

Posiflush saline syringe, by BD (2 mentions) K2edta map tubes, by BD (2 mentions) Sodium citrate minicollect tubes, by Greiner (2 mentions) Posiflush pre filled heparin lock syringes, by BD (2 mentions) Tiletamine hcl, by Zoetis (2 mentions) Zolazepam hcl, by Zoetis (2 mentions) Clot activator tube, by BD (1 mentions) 30 gauge needle, by BD (1 mentions) Dissecting knife, by Fine Science Tools (1 mentions) Rongeurs, by Fine Science Tools (1 mentions)

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Ketamine (71 citations)

5 protocols using ketamine hcl

Anesthesia Protocol for Feline Elective Surgeries

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The study was reviewed and approved by the Board of Directors of the Hill Country Animal League acting as an ad hoc institutional ethical review committee. Owner consent was obtained before entering patients into the study.
Twenty male and 20 female, apparently healthy, cats presenting for elective OHE or castration were entered into the study. Cats were weighed and confirmed to be 0.9 kg body weight and 2 months of age, as reported by the owner/agent and confirmed by dentition. Before sample collection, cats were anesthetized with a standardized protocol, including buprenorphine, ketamine, dexmedetomidine and isoflurane. Equal volumes of ketamine (100 mg/ml; Ketamine HCl [VEDCO]) and dexmedetomidine (0.5 mg/ml; Dexmedetomidine HCl [Putney]) were mixed in a single sterile vial. Anesthesia was induced by an intramuscular injection of 0.4 ml of this mixture. The total dosage of induction drugs ranged from 3.4 mg/kg to 7.3 mg/kg for ketamine and from 0.02 mg/kg to 0.04 mg/kg for dexmedetomidine. Buprenorphine (0.01 mg/kg IM; Buprenorphine Injection PF [Roadrunner Pharmacy]) was administered after the induction of anesthesia. The cats had small animal transparent anesthesia masks placed over their faces and isoflurane was admin-istered with a vaporizer setting range of 0.5-1% (Isoflurane; MWI). Oxygen flow was 2 l/min using a non-rebreathing circuit.

Fudge J.M., Cano K.S., Page B, & Jeffery U. (2021). Comparison of viscoelastic test results from blood collected near simultaneously from the jugular and saphenous veins in cats. Journal of feline medicine and surgery, 23(6).

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Canine Central Venous Catheter Sampling

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CVCs were flushed with saline from a 10 mL PosiFlush saline syringe (BD Biosciences, San Jose, CA, USA) prior to blood draw. The daily collection of blood samples from each CVC occurred between DPE-3 and DPE 10 with a 2.5 mL volume collected with a 5 mL syringe distributed into 1 mL sodium citrate MiniCollect tubes (Greiner Bio-One, Monroe, NC, USA), 1 mL clot activator tubes (BD Biosciences), and 0.5 mL K2EDTA MAP tubes. Saline was used to again flush the CVC line, which was then maintained by flushing with PosiFlush pre-filled heparin lock syringes (BD Biosciences). These syringes were left attached to the CVC cage-side port until the next sample collection. Animals were anesthetized with ketamine HCl at 10 mg/kg (VedCo, Saint Joseph, MO, USA) or a combination of tiletamine HCl and zolazepam HCl at 3 mg/kg (Fort Dodge Animal Health, New York, NY, USA) on days where sampling through the CVC was complicated due to kinked lines. When animals were anesthetized, blood was drawn via the saphenous vein.

Downs I., Johnson J.C., Rossi F., Dyer D., Saunders D.L., Twenhafel N.A., Esham H.L., Pratt W.D., Trefry J., Zumbrun E., Facemire P.R., Johnston S.C., Tompkins E.L., Jansen N.K., Honko A, & Cardile A.P. (2021). Natural History of Aerosol-Induced Ebola Virus Disease in Rhesus Macaques. Viruses, 13(11), 2297.

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Nicotine, Mecamylamine, and Ethanol Study

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(-)-Nicotine hydrogen tartrate salt [(-)-1-methyl-2-(3-pyridyl) pyrrolidine (-)-bitartrate salt] and mecamylamine were purchased from Sigma-RBI (Natick, MA, USA). Ketamine HCl was purchased from Vedco Inc. (Saint Joseph, MO). Varenicline and sazetidine were obtained from the Drug Supply Program of the National Institute on Drug Abuse (Rockville, MD). These drugs were dissolved in 0.9% saline and injected subcutaneously (s.c.) at a volume of 10 ml/kg body weight. Ethanol was also dissolved in 0.9% saline and prepared as a 20% (v/v) solution and was delivered via intraperitoneal (i.p.) injection. All doses are expressed as the free base of the drug.

Slater C.A., Jackson A., Muldoon P.P., Dawson A., O’Brien M., Soll L.G., Abdullah R., Carroll F.I., Tapper A.R., Miles M.F., Banks M.L., Bettinger J.C, & Damaj M.I. (2016). Nicotine enhances the hypnotic and hypothermic effects of alcohol in the mouse. Alcoholism, clinical and experimental research, 40(1), 62-72.

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Cervical Spinal Cord Hemisection in Rats

Cited 1 time

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Rats were anesthetized with an intraperitoneal injection of ketamine HCl (95.0 mg/kg; Vedco), xylazine (10.0 mg/kg; Lloyd Laboratories), and acepromazine (0.075 mg/kg; Phoenix Pharm Inc). Using a #11 surgical blade (Electron Microscopy Sciences), a one-inch midline incision was made on the dorsal surface of skin and muscle to expose the dorsal surface of the C2 and C3 vertebrae. A laminectomy was performed above C2 to expose the spinal cord using rongeurs (Fine Science Tools). A hemisection was performed just caudal to the C2 root with a dissecting knife (Fine Science Tools; Urban et al., 2018 (link)). To ensure a complete hemisection, a 30-gauge needle (BD Biosciences) was passed through the injury several times.

Urban M.W., Ghosh B., Block C.G., Strojny L.R., Charsar B.A., Goulão M., Komaravolu S.S., Smith G.M., Wright M.C., Li S, & Lepore A.C. (2019). Long-Distance Axon Regeneration Promotes Recovery of Diaphragmatic Respiratory Function after Spinal Cord Injury. eNeuro, 6(5), ENEURO.0096-19.2019.

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Blood Sampling Protocols for NHP Challenge

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Prior to drawing blood samples, the CVC was flushed with saline from a 10 mL PosiFlush saline syringe (BD Biosciences, San Jose, CA, USA). Blood samples were collected daily from each NHP’s CVC between days 3 through 16 post-exposure with a 5 mL syringe and aliquoted into 0.5 mL K2EDTA MAP tubes (BD Biosciences), 1 mL serum with clot activator tubes, and 1 mL sodium citrate MiniCollect tubes (Greiner Bio-One, Monroe, NC, USA). After day 16, blood was collected from the survivor on day 30 and 41. The CVC line was again flushed with saline and maintained by flushing with PosiFlush pre-filled heparin lock syringes (BD Biosciences), which were left attached to the CVC until the next sample collection. On days where sampling via CVC was complicated due to kinking of the line, NHPs were anesthetized with ketamine HCl at 10 mg/kg (VedCo, Saint Joseph, MO, USA) or a combination of Tiletamine HCl and Zolazepam HCl at 3 mg/kg (Fort Dodge Animal Health, New York, NY, USA). Survivor and D10:Non-survivor had catheter kinking three days prior to challenge; no other kinks are noted. Once anesthetized, blood was drawn via saphenous venipuncture.

Downs I.L., Shaia C.I., Zeng X., Johnson J.C., Hensley L., Saunders D.L., Rossi F., Cashman K.A., Esham H.L., Gregory M.K., Pratt W.D., Trefry J.C., Everson K.A., Larcom C.B., Okwesili A.C., Cardile A.P, & Honko A. (2020). Natural History of Aerosol Induced Lassa Fever in Non-Human Primates. Viruses, 12(6), 593.

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