Dri chem 4000

Manufactured by Heska

Sourced in United States

The DRI-CHEM 4000 is a compact, automated chemistry analyzer designed for in-house laboratory testing. It provides fast and reliable analysis of a wide range of biochemical parameters from small sample volumes. The DRI-CHEM 4000 is a self-contained system that automates the testing process, offering efficient and consistent results.

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Lab products found in correlation

Hematrue analyzer, by Heska (1 mentions) Ethylene diamine tetraacetic acid (edta), by BD (1 mentions) Sst tube, by BD (1 mentions) Elisa kit, by Abcam (1 mentions) Enzyme immunoassay kit, by R&D Systems (1 mentions) Advia 120 hematology analyzer, by Siemens (1 mentions) Porcine cytokine chemokine array 13 plex, by Eve Technologies (1 mentions) Edta vacuette tube, by Greiner (1 mentions) Hematrue, by Heska (1 mentions)

10 protocols using dri chem 4000

Comprehensive Metabolic Blood Biochemistry

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A comprehensive 18-parameter metabolic blood biochemistry analysis was performed on all serum samples to evaluate liver and kidney function, as well as electrolyte and fluid balance. All tests were performed per the manufacturer’s recommendations using a DRI-CHEM 4000 (Heska).

Westover J.B., Rigas J.D., Van Wettere A.J., Li R., Hickerson B.T., Jung K.H., Miao J., Reynolds E.S., Conrad B.L., Nielson S., Furuta Y., Thangamani S., Wang Z, & Gowen B.B. (2017). Heartland virus infection in hamsters deficient in type I interferon signaling: protracted disease course ameliorated by favipiravir. Virology, 511, 175-183.

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Postoperative Serum Creatinine Measurement

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SCr was measured at 6, 24, and 72 hours postoperatively after the ischemic event. After obtaining a 1 mL blood sample from the marginal auricular vein, we centrifuged the sample at 3,000 rpm for 5 minutes. Measurement of SCr was performed using a DRI-CHEM 4000 chemistry analyzer (Heska, Loveland, CO).

Yoon Y.E., Lee K.S., Choi K.H., Kim K.H., Yang S.C, & Han W.K. (2015). Preconditioning Strategies for Kidney Ischemia Reperfusion Injury: Implications of the “Time-Window” in Remote Ischemic Preconditioning. PLoS ONE, 10(4), e0124130.

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Hematology and Serum Analysis of Infected Mice

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Three groups were analyzed by one-way analysis of variance (ANOVA); uninfected control (n = 3), euthanized due to disease (n = 6), and infected (asymptomatic) survivors (n = 3). Hematology was performed on whole blood collected in EDTA (Becton–Dickinson, Franklin Lakes, NJ, USA) using a Heska HemaTrue Analyzer. Blood collected into SST tubes (Becton-Dickinson) was centrifuged at 1000× g for 10 min at 4 °C and serum analyzed with a Heska DRI-CHEM 4000 chemistry analyzer (Heska, Loveland, CO, USA).

Campbell C.L., Phillips A.T., Rico A., McGuire A., Aboellail T.A., Quackenbush S., Olson K.E, & Schountz T. (2018). Involvement of Pro-Inflammatory Macrophages in Liver Pathology of Pirital Virus-Infected Syrian Hamsters. Viruses, 10(5), 232.

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Mouse Serum Liver Function Analysis

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Liver function tests were performed by loading 150 μL undiluted mouse serum into a Dri-chem 4000 chemistry analyzer (Heska, Loveland, CO, USA) using the Heska liver function panel cartridges.

Watters C.R., Barro O., Elliott N.M., Zhou Y., Gabere M., Raupach E., Baker A.T., Barrett M.T., Buetow K.H., Jacobs B., Seetharam M., Borad M.J, & Nagalo B.M. (2023). Multi-modal efficacy of a chimeric vesiculovirus expressing the Morreton glycoprotein in sarcoma. Molecular Therapy Oncolytics, 29, 4-14.

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Cytokine and ALT Measurement Protocols

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ELISA kits (Abcam, Cambridge, MA) were used according to the manufacturer's instructions to measure the levels of cytokines interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α). Serum alanine aminotransferase (ALT) was measured with Heska DRI-Chem 4000 (Heska, Tokyo, Japan).

Waltz P.K., Kautza B., Luciano J., Dyer M., Stolz D.B., Loughran P., Neal M.D., Sperry J.L., Rosengart M.R, & Zuckerbraun B.S. (2018). Heme Oxygenase-2 Localizes to Mitochondria and Regulates Hypoxic Responses in Hepatocytes. Oxidative Medicine and Cellular Longevity, 2018, 2021645.

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Quantifying Inflammation and Organ Injury

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Heparinized blood samples were centrifuged at 2000g for 15 minutes, serum was collected, and samples were stored at −80°C for future analysis. Peritoneal fluid samples remaining after plating bacterial cultures were stored at −80°C for future analysis. Thawed samples then underwent quantitative analysis for markers of inflammation (IL-6, TNFα, IL-10) and renal failure (Cystatin C) using enzyme immunoassay kits (R&D Systems, Minneapolis, MN). Cystatin C has emerged as a more precise marker of glomerular filtration rate and has been validated in murine and human studies (46 (link)–48 (link)). Liver injury was quantified by measuring alanine aminotransferase (ALT) using a Heska DRI-CHEM 4000 automated dry chemistry analyzer (Heska, Loveland, CO).

Lewis A.J., Yuan D., Zhang X., Angus D.C., Rosengart M.R, & Seymour C.W. (2016). Use of biotelemetry to define physiology-based deterioration thresholds in a murine cecal ligation and puncture model of sepsis. Critical care medicine, 44(6), e420-e431.

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Comprehensive Plasma Biochemistry and Hematology

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To evaluate liver and kidney parameters during the course of infection, a comprehensive 18-parameter plasma biochemistry panel was performed on all plasma samples. Parameters tested include total protein (TP), albumin (ALB), alkaline phosphatase (ALP), glucose (GLU), total bilirubin (TBIL), phosphate (PHOS), cholesterol (CHOL), gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), calcium (Ca), creatinine (CRE), blood urea nitrogen (BUN), and aspartate aminotransferase (AST). The analysis was performed using a DRI-CHEM 4000 (HESKA; Des Moines, IA) according to the manufacturer’s recommendations.
For determination of complete blood counts, EDTA-anticoagulated whole-blood samples were analyzed on an automated Advia 120 Hematology Analyzer (Siemens Healthcare Diagnostic Inc., Tarrytown, NY, USA) to obtain red blood cell (RBC) counts, calculated hemoglobin (calc HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean cell hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), cell hemoglobin concentration mean (CHCM), red cell distribution width (RDW), white blood cell (WBC) counts, band neutrophil (Band) counts, neutrophil (Neut) counts, lymphocyte (Lymph) counts, monocyte (Mono) counts, eosinophil (Eos) counts, basophil (Baso) counts, platelet (PLT) counts, and mean platelet volume (MPV).

Hickerson B.T., Westover J.B., Van Wettere A.J., Rigas J.D., Miao J., Conrad B.L., Motter N.E., Wang Z, & Gowen B.B. (2018). Pathogenesis of Rift Valley Fever Virus Aerosol Infection in STAT2 Knockout Hamsters. Viruses, 10(11), 651.

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Biomarkers in Sepsis-Induced Kidney Injury

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Blood samples were obtained from cardiac puncture at 8 and 24 hours post-CLP. Cystatin C was determined from serum using a mouse Cystatin C kit according to the manufacturer’s instructions (R&D systems, Minneapolis, MN). Serum concentration of BUN, Creatinine, ALT and AST was determined with a HESKA DRI-CHEM 4000 chemistry analyzer (Loveland, CO).

Escobar D.A., Botero-Quintero A.M., Kautza B.C., Luciano J., Loughran P., Darwiche S., Rosengart M.R., Zuckerbraun B.S, & Gomez H. (2014). AMPK Activation Protects Against Sepsis-Induced Organ Injury and Inflammation. The Journal of surgical research, 194(1), 262-272.

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Comprehensive Porcine Biomarker Analysis

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Blood samples were collected via the arterial sheath side port during the procedure and prior to euthanasia. The blood samples were either collected in EDTA-Vacuette tube (Greiner Bio-One, North American, Inc., Monroe, NC), or allowed to clot in a Vacuette tube for 30 minutes at room temperature and then centrifuged at 1,500 xg for 5 minutes to obtain serum aliquots. Complete blood count and serum levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), creatinine (CRE), blood urea nitrogen (BUN), glucose (Glu) were measured using an automated analyzer (HemaTrue, Heska, Loveland, CO) and a Veterinary Chemistry Analyzer (DRI-CHEM 4000, Heska, Loveland, CO), respectively. Serum samples were analyzed using the porcine cytokine/chemokine array 13-plex (Eve Technologies, Calgary, CA) and the analyte concentrations were expressed in picogram per mL.

Zhang Z., Albadawi H., Fowl R.J., Altun I., Salomao M.A., Jahanyar J., Chong B.W., Mayer J.L, & Oklu R. (2022). Treatment of Ruptured and Non-Ruptured Aneurysms Using a Semi-Solid Iodinated Embolic Agent. Advanced materials (Deerfield Beach, Fla.), 34(10), e2108266.

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Liver Enzyme Quantification Protocol

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Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, and total bilirubin were measured using HesKa Dri‐Chem 4000 (Heska, Loveland, CO, USA).

Xia Y., He J., Zhang H., Wang H., Tetz G., Maguire C.A., Wang Y., Onuma A., Genkin D., Tetz V., Stepanov A., Terekhov S., Ukrainskaya V., Huang H, & Tsung A. (2020). AAV‐mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response. Molecular Oncology, 14(11), 2920-2935.

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