All MRI scanning was performed at the Imaging Research Center, UC Davis, Sacramento, during natural nocturnal sleep without sedation [47 (link)] from October 2009 to July 2018, using a 3-T Siemens Magnetom Trio MR system (Erlangen, Germany) with an 8-channel head coil. High-resolution T1 images were acquired using an MPRAGE sequence (1 mm3 resolution, TR = 2170 ms, TE = 4.86 ms, TI = 1100 ms, FA = 7°, 192 slices, 256 × 256 × 192 mm FOV). Diffusion-weighted images (DWI) were acquired in 30 independent directions along with five interleaved non-diffusion weighted (b = 0) images (1.9 mm3 resolution, TR = 8500 ms, TE = 81 ms, b = 700, echo spacing = 0.69 ms, GRAPPA iPAT factor = 2, 72 slices, 243 × 243 × 137 mm FOV). An accompanying phase map image was acquired using the same shim as the DWI sequence to correct for field inhomogeneities (4 mm3 resolution, TR = 1000 ms, TE = 3.60/6.06 ms, FA = 90°, 48 slices, 256 × 256 × 230 mm FOV).
Magnetom trio mr system
Manufactured by Siemens
Sourced in Germany
The Magnetom Trio MR system is a magnetic resonance imaging (MRI) device developed by Siemens. It is designed to capture high-quality images of the human body for diagnostic purposes. The system utilizes a strong magnetic field and radio waves to generate detailed images of internal structures, enabling healthcare professionals to assess and monitor various medical conditions.
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Lab products found in correlation
3 protocols using magnetom trio mr system
1
Multimodal Brain Imaging During Sleep
2
MRI Acquisition and Cortical Thickness Analysis
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All MRI scanning was performed at the UC Davis Imaging Research Center, using a 3 Tesla Siemens Magnetom Trio MR system (Erlangen, Germany) with an 8-channel head coil. High resolution T1 images were acquired for Time One -Three scans during natural nocturnal sleep without sedation [44] . Time Four scans were acquired when participants were awake utilizing principles of applied behavior analysis to improve compliance [45] , in addition to a modified sequence to shorten scanning duration.
Cortical thickness was estimated from cortical surface reconstructions of structural MRI scans using Freesurfer v7.1.1 [43, 46] . These methods have been extensively described elsewhere [47, 48] , and results validated histologically [49] . All surface reconstructions were visually inspected for quality and, when appropriate, manual edits were performed to improve reconstruction quality. Of 1115 eligible MRI timepoints a total of 197 (15%) were excluded due to quality issues that could not be corrected by manual edits and are not described in this study (Supplementary Methods).
Cortical thickness was estimated from cortical surface reconstructions of structural MRI scans using Freesurfer v7.1.1 [43, 46] . These methods have been extensively described elsewhere [47, 48] , and results validated histologically [49] . All surface reconstructions were visually inspected for quality and, when appropriate, manual edits were performed to improve reconstruction quality. Of 1115 eligible MRI timepoints a total of 197 (15%) were excluded due to quality issues that could not be corrected by manual edits and are not described in this study (Supplementary Methods).
3
4D Flow MRI of Bicuspid Aortic Valve
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Three BAV-affected patients without complex congenital heart diseases (2 males, age 19,28,31) were recruited prospectively. Three healthy volunteers (3 males, age 17,23,25) were enrolled as controls. 4D-flow acquisitions were performed at John Radcliffe Hospital (Oxford, United Kingdom). Flow-sensitive gradient-echo pulse sequences were acquired with prospective ECG-gating during freebreathing, using a respiratory navigator, on a 3.0 T Magnetom Trio MR system (Siemens, Erlangen, Germany). The acquisition volume was oriented along an oblique-sagittal plane encompassing the whole thoracic aorta, as well as the ascending aorta and the aortic arch. 4D-flow sequences were set with the following specifics: i) voxel sizing¼1.67C2.2 mm 3 ; ii) VENC¼150C370 cm/s; iii) Flip Angle¼7°; iv) Echo Time¼2.3C2.5 ms; v) Repetition Time¼40 ms. The Institu-tional Review Board approved the study and informed consent was obtained from each participant. The time-frame with the highest velocity-to-noise ratio was chosen as the most representative of peak systole and selected for post-processing.
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