The specific DOT1L inhibitor EPZ-5676 was obtained from Chemietek. Lithium chloride and EX527 were purchased from Sigma, XAV-939 from Selleck and SRT1720 from Calbiochem. HiPerFect and all siRNAs except DOT1L siRNA were purchased from Qiagen (Supplementary Table 2 ). DOT1L siRNA and lipofectamine RNAimax were purchased from Invitrogen. Recombinant human WNT3A protein was purchased from R&D Systems.
Epz 5676
Manufactured by Chemietek
Sourced in United States
The EPZ-5676 is a laboratory equipment designed for performing various experimental tasks. It is a multi-purpose device that can be utilized in a range of scientific applications. The core function of the EPZ-5676 is to facilitate controlled and precise experimentation, but the specific details of its intended use are not provided in this factual and unbiased description.
Automatically generated - may contain errors
Lab products found in correlation
Lithium chloride (licl), by Merck Group (1 mentions)
Xav939, by Selleck Chemicals (1 mentions)
Dot1l sirna, by Thermo Fisher Scientific (1 mentions)
Recombinant human wnt3a protein, by R&D Systems (1 mentions)
Ex 527, by Merck Group (1 mentions)
Lipofectamine rnaimax, by Thermo Fisher Scientific (1 mentions)
Hiperfect, by Qiagen (1 mentions)
Gsk126, by Chemietek (1 mentions)
Unc0638, by Merck Group (1 mentions)
S2101, by Merck Group (1 mentions)
Gsk2879552, by Chemietek (1 mentions)
Sgc0946, by Merck Group (1 mentions)
Gsk j1, by Merck Group (1 mentions)
2 protocols using epz 5676
1
Inhibition and Knockdown of DOT1L in Cell Lines
2
Epigenetic Modulators: Inhibitor Evaluation
Check if the same lab product or an alternative is used in the 5 most similar protocols
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The H3K4 methyltransferase LSD1 inhibitor S2101 was purchased from Merck Millipore (Burlington, MA, USA). The LSD1 inhibitor GSK2879552, H3K27 methyltransferase EZH2 inhibitor GSK126, and H3K79 methyltransferase DOT1L inhibitor EPZ-5676 were all purchased from Chemietek (Indianapolis, IN, USA). The H3K9 methyltransferase G9a inhibitor UNC0638, H3K27 demethylase JMJD3/UTX inhibitor GSKJ1, DOT1L inhibitor SGC0946, and MYC inhibitor 10058-F4 were all purchased from Sigma-Aldrich (St. Louis, MO, USA).
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