Micro ct

Manufactured by Bruker

Sourced in Belgium, United States, Germany

The Micro-CT is a compact, high-resolution computed tomography (CT) imaging system designed for the analysis of small samples. It provides detailed three-dimensional (3D) visualization and quantification of the internal structure and composition of a wide range of materials and specimens.

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Lab products found in correlation

Skyscan 1172, by Bruker (6 mentions) Skyscan 1176, by Bruker (6 mentions) Skyscan 1272, by Bruker (4 mentions) Ctvox, by Bruker (3 mentions) Dataviewer, by Bruker (3 mentions) Skyscan 1076 system, by Bruker (2 mentions) Skyscan 1174v2, by Bruker (2 mentions) Nrecon v1, by Bruker (2 mentions) Skyscan 1173, by Bruker (2 mentions) Skyscan 1275, by Bruker (2 mentions) Nrecon, by Bruker (2 mentions) Skyscan, by Bruker (2 mentions) Mct 35, by Scanco (2 mentions) Ct analyzer, by Bruker (1 mentions) Ctan software, by Bruker (1 mentions) Askyscan 1176, by Bruker (1 mentions) Ct analyser software, by Bruker (1 mentions) Dm6 microscope, by Leica camera (1 mentions) Iohexol, by Merck Group (1 mentions) Skyscan 1173 scanner, by Bruker (1 mentions)

115 protocols using micro ct

Quantifying Root Canal Treatment Outcomes

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After reconstruction with NRecon (Bruker micro CT, Kontich, Belgium) software, the volume of the tooth tissue was analyzed with CT-AN software (Bruker micro CT, Kontich, Belgium), we selected appropriate CT value as the segmentation of tooth volume. After the pretreatment scan and post-treatment scan were aligned in Data Viewer software (Bruker micro CT, Kontich, Belgium), the increased canal volume and surface areas after root canals shaped during the two different access opening procedures were measured using CT-An software. The proportion of untouched canal wall (UCW) in the canals was determined with 3-Matic (Fig. 3), and we measured the sectional section of 1, 3, and 5 mm from the apical and the deviation of the central point in Solid Work (Dassault, France) (Fig. 4). The percentage volume of root filling materials and any voids inside the region of interest were calculated in CT-An software, and all areas without filling within the root canal space were considered voids.
Fig. 3

Preoperative (green) (a), postoperative (red), b and the aligned root canal (c) in 3-matic

Fig. 4

a The 1, 3, and 5 mm section from the apical. b The deviation of central point in Solid Work. Preoperative (aquamarine) and postoperative (mazarine)

Xia J., Wang W., Li Z., Lin B., Zhang Q., Jiang Q, & Yang X. (2020). Impacts of contracted endodontic cavities compared to traditional endodontic cavities in premolars. BMC Oral Health, 20, 250.

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Micro-CT Analysis of Bone Microstructure

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Samples were scanned using a micro-CT scanner (Bruker micro-CT, USA). All images were manipulated manually to separate cancellous and cortical bone and preserve their morphology. Scans were repeated three times, with bone microstructural parameters acquired from the same region of interest (ROI) for each group. Structural parameters of the ROI, including trabecular bone volume/tissue volume (BV/TV), trabecular number (Tb.N), trabecular separation (Tb.Sp) and trabecular thickness (Tb.Th) were analyzed with image reconstruction software (NRecon, USA), data analysis software (Bruker micro-CT, USA), and 3-dimensional model visualization software (Bruker micro-CT, USA).

Wang J., Xie X., Li H., Zheng Q., Chen Y., Chen W., Chen Y., He J, & Lu Q. (2024). Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development. iScience, 27(4), 109608.

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Femoral Bone Morphometry Analysis

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Mice were killed 1 month after surgery and right femurs were harvested for bone morphometric analysis. Femurs were analyzed with high‐resolution micro‐computed tomography (micro‐CT) using a Skyscan 1172 scanner (Skyscan). These qualitative and quantitative imaging analyses were mainly focused on the distal metaphysis of the femurs. The radiographic projections (n = 210) were acquired at 80 kV and 100 mA with an exposure time of 100 ms and a 0.5‐mm aluminum filter. Ten frames were averaged for each rotation increment of 0.5° to increase the signal‐to‐noise ratio. Three‐dimensional (3D) images were reconstructed with a mean voxel size of 6 μm, using the manufacturer's reconstruction software NRecon version 1.6.2.0 (Skyscan, Bruker microCT). Cortical bone thickness (Crt.Th_3D) was analyzed in the midshaft of the femur over 300 μm at 4 mm from the growth plate cartilage. Trabecular bone was analyzed at the distal femoral metaphysis. Trabecular bone volume (BV/TV_3D), trabecular number (Tb.N_3D), trabecular separation (Tb.Sp_3D), and trabecular thickness (Tb.Th_3D) were quantified using the resident software CTAn version 1.10.1.0 (Skyscan, Bruker microCT).

Jehan F., Zarka M., de la Houssaye G., Veziers J., Ostertag A., Cohen‐Solal M, & Geoffroy V. (2022). New insights into the role of matrix metalloproteinase 3 (MMP3) in bone. FASEB BioAdvances, 4(8), 524-538.

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Ovariectomy-induced Bone Loss in Mice

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For animal studies in vivo, mice were randomized for weight. For the OVX-induced bone loss model, 2-month-old female C57BL/6 mice were sham-operated (sham) or ovariectomized (OVX) and randomly divided into indicated groups. Vehicle, Kp-10 or (DSS)*6-Kp-10 was injected into the tail vein twice per week. After two months of treatment, the femurs and the L3 lumbrae were isolated for micro-CT or histomorphometric analysis. 3D micro-CT analyses were performed according to a standard protocol. BMD and bone volume were analyzed by CT-analysis software (CTAn, Bruker micro CT, Kontich, Belgium) and images were reconstituted by CT-volume software (CTvol, skyscan, CTAn, Bruker micro CT, Kontich, Belgium).

Li Z., Yang X., Fu R., Wu Z., Xu S., Jiao J., Qian M., Zhang L., Wu C., Xie T., Yao J., Wu Z., Li W., Ma G., You Y., Chen Y., Zhang H.K., Cheng Y., Tang X., Wu P., Lian G., Wei H., Zhao J., Xu J., Ai L., Siwko S., Wang Y., Ding J., Song G., Luo J., Liu M, & Xiao J. (2024). Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nature Communications, 15, 1300.

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3D Root Canal Modeling Using CTAn

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The automatic segmentation and surface modeling with CTAn v. 1.12 software (Bruker-microCT) were used to reconstruct the 3D models. The qualitative evaluation of the specimens was conducted using the CTVol v. 2.2.1 and DataViewer v1.5.1 software (Bruker-microCT, SkyScan, Belgium). Then, the root canal configurations were classified according to Gao et al.[18 (link)] into merging (Type I), symmetrical (Type II), and asymmetrical (Type III) [Figure 1].

Amoroso-Silva P., De Moraes I.G., Marceliano-Alves M., Bramante C.M., Zapata R.O, & Hungaro Duarte M.A. (2018). Analysis of mandibular second molars with fused roots and shallow radicular grooves by using micro-computed tomography. Journal of Conservative Dentistry : JCD, 21(2), 169-174.

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Micro-CT Analysis of Alveolar Bone

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To observe the morphological changes in the alveolar bone, maxillae were scanned by micro-CT (Bruker micro-CT, Kontich, Belgium). The computed tomography was set according to slice thickness (18 µm), voltage (50 kV), and electrical current (455 µA). Three-dimensional images were made using the Bruker micro-CT version 1.1 (Bruker micro-CT, Kontich, Belgium).

Cui D., Li H., Lei L., Chen C, & Yan F. (2016). Nonsurgical periodontal treatment reduced aortic inflammation in ApoE−/− mice with periodontitis. SpringerPlus, 5(1), 940.

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Volumetric Analysis of Remaining Endodontic Filling

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The pre- and postoperative scans were geometrically aligned using the 3D registration function of DataViewer v. 1.5.1 software and the CTAn v. 1.14.4 software (Bruker micro-CT, Bruker Corp. Billerica, MA, USA) was used to process the image datasets. Binary images of the dentin and filling material were generated by utilizing task lists. A customized processing tool with functions and mathematical operations was used for this purpose. Using the grayscale threshold, we were able to clearly define the area that is dentin, the area that constituted filling materials and which areas were actually voids. The area that constituted the filling materials was chosen as the region of interest. This was done in each cross section and by the integration of the regions of interest of all the cross sections, the final volume of interest was calibrated and calculated. For the quantitative volumetric analysis of the remaining filling material including gutta-percha and sealer, CTVol v. 2.2.1 (Bruker micro-CT, Bruker Corp. Billerica, MA, USA) was used. A blinded observer then analyzed the remaining volume of filling material in each specimen.

Sairaman S., Solete P., Jeevanandan G., Antony S.D., Kavoor S, & Adimulapu H.S. (2024). Comparative analysis of novel heat-treated retreatment file system on the removal of obturating material using nano-computed tomography. Journal of Conservative Dentistry and Endodontics, 27(1), 82-86.

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Predicting Bone Microstructure from Imaging Data

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To provide the ground-truth reference for bone microstructure prediction, we utilized a previously collected dataset [23 (link)] consisting of 53 osteochondral samples from nine TKA patients and two deceased cadavers without an OA diagnosis (Table 1; ethical approval PPSHP 78/2013, PSSHP 58/2013 & 134/2015). The samples were imaged using two devices: a clinical extremity CBCT (Planmed Verity, Planmed Inc., Helsinki, Finland; parameters: 80 kV, 12 mA, 200 µm voxel size, 20 ms exposure time) and a laboratory desktop µCT scanner (Skyscan 1272, Bruker Inc., Kontich, Belgium; parameters: 50 kV, 200 µA 2.75 µm voxel size, 2200 ms exposure time, 0.5 mm Al filter, 135 min scan time). The samples were imaged with the µCT one at a time, and with the CBCT scanner, a large batch of samples were imaged during one scan. The projection images were reconstructed with the corresponding manufacturer’s reconstruction software with a “standard” reconstruction filter applied for CBCT, and beam hardening and ring artifact corrections were applied for µCT (Nrecon, v.1.6.10.4, Bruker microCT, 20-70 min reconstruction time). The reconstructed volumes were coregistered to the same coordinate system using rigid transformations on the Bruker Dataviewer software (version 1.5.4, Bruker microCT).

Rytky S.J., Tiulpin A., Finnilä M.A., Karhula S.S., Sipola A., Kurttila V., Valkealahti M., Lehenkari P., Joukainen A., Kröger H., Korhonen R.K., Saarakkala S, & Niinimäki J. (2024). Clinical Super-Resolution Computed Tomography of Bone Microstructure: Application in Musculoskeletal and Dental Imaging. Annals of Biomedical Engineering, 52(5), 1255-1269.

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Fracture Healing Evaluation via Micro-CT

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The femoral bones were photographed by a softex X-ray apparatus (Softex CSM-2; Softex, Tokyo, Japan) at week 2, week 4, and week 8 post-fracture. Femora were scanned by a micro-CT system (Bruker-microCT, SkyScan 1176, Kontich, Antwerpen, Belgium) at 8 weeks post-fracture. The scan protocol was set as follows: 18-μm isometric voxel size, 800 mA, and 80 kVp. Taking the fracture line as the midpoint reference, a total of 200 slices between the proximal and distal were analyzed. The callus was manually drawn as a region of interest, then the bone parameters of high-density bone volume (BV), total bone volume (TV), the volume fractions (BV/TV), and bone mineral density (BMD) were analyzed with CTAn software version 1.13 (Bruker-microCT). The three-dimensional representative images were generated by CTXox software version 3.3 (Bruker-microCT).

Zhang L., Jin L., Guo J., Bao K., Hu J., Zhang Y., Hou Z, & Zhang L. (2021). Chronic Intermittent Hypobaric Hypoxia Enhances Bone Fracture Healing. Frontiers in Endocrinology, 11, 582670.

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High-Resolution Micro-CT Imaging of Hind Limbs

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Scanning was carried out using a SkyScan 1076 system (Bruker microCT; Kontich, Belgium) at the following settings: 12.25-µm resolution, 70 kV, 141 µA, and Al 0.5-mm filter. The images were reconstructed using NRecon software (Bruker microCT; Kontich). The cross-sectional images of the hind limb were captured using CTAn and CTvox software (Bruker microCT; Kontich).

Kim J.C., Kang Y.S., Noh E.B., Seo B.W., Seo D.Y., Park G.D, & Kim S.H. (2018). Concurrent treatment with ursolic acid and low-intensity treadmill exercise improves muscle atrophy and related outcomes in rats. The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 22(4), 427-436.

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