Malonic acid

Manufactured by Tokyo Chemical Industry

Sourced in Japan

Malonic acid is a dicarboxylic acid with the chemical formula CH2(COOH)2. It is a white, crystalline solid used as a laboratory reagent and intermediate in organic synthesis.

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Lab products found in correlation

2 thenoyltrifluoroacetone, by Merck Group (1 mentions) Oligomycin a, by Merck Group (1 mentions) Antimycin a, by Merck Group (1 mentions) Rotenone, by Merck Group (1 mentions) Choline chloride, by Tokyo Chemical Industry (1 mentions) Fetal bovine serum (fbs), by Corning (1 mentions) Antibiotic antimycotic, by Thermo Fisher Scientific (1 mentions) Dulbecco s modified eagle s medium, by Welgene (1 mentions)

3 protocols using malonic acid

Murine BV2 Microglial Cell Culture

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The murine BV2 microglial cell line was obtained from the Korea Cell Line Bank. The cells were cultured in Dulbecco's Modified Eagle’s Medium (Welgene, Korea) containing 10% fetal bovine serum (Corning Costar, USA) and 1% antibiotic-antimycotic (Gibco, USA) in a 37°C incubator in an atmosphere of 5% CO₂. Malonic acid was purchased from Tokyo Chemical Industry Co., Ltd. Malonic acid was dissolved in dimethyl sulfoxide (DMSO).

Lee H., Jang J.H, & Kim S.J. (2021). Malonic acid suppresses lipopolysaccharide-induced BV2 microglia cell activation by inhibiting the p38 MAPK/NF-κB pathway. Animal Cells and Systems, 25(2), 110-118.

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Mitochondrial Electron Transport Chain Inhibitors

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T-2307 was synthesized by FUJIFILM Toyama Chemical Co., Ltd. (Tokyo, Japan). Antimycin A, rotenone, 2-thenoyltrifluoroacetone (TTFA), and oligomycin A were purchased from Sigma-Aldrich (St. Louis, MO, USA). KCN and CCCP were purchased from FUJIFILM Wako Pure Chemical Corporation (Osaka, Japan). Malonic acid was purchased from Tokyo Chemical Industry (Tokyo, Japan).

Yamashita K., Miyazaki T., Fukuda Y., Mitsuyama J., Saijo T., Shimamura S., Yamamoto K., Imamura Y., Izumikawa K., Yanagihara K., Kohno S, & Mukae H. (2019). The Novel Arylamidine T-2307 Selectively Disrupts Yeast Mitochondrial Function by Inhibiting Respiratory Chain Complexes. Antimicrobial Agents and Chemotherapy, 63(8), e00374-19.

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Tadalafil and Lidocaine Formulation

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Tadalafil (TDF) and lidocaine HCl (LDC) were kindly gifted by the Jordanian Pharmaceutical Company (JPM) Amman, Jordan. Choline chloride and malonic acid were purchased from Tokyo Chemical Industry Co., Ltd. (TCI), Tokyo, Japan.

Alkhawaja B., Al-Akayleh F., Al-Khateeb A., Nasereddin J., Ghanim B.Y., Bolhuis A., Jaber N., Al-Remawi M, & Qinna N.A. (2023). Deep Eutectic Liquids as a Topical Vehicle for Tadalafil: Characterisation and Potential Wound Healing and Antimicrobial Activity. Molecules, 28(5), 2402.

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