11 ketotestosterone

Manufactured by Steraloids

11-ketotestosterone is a naturally occurring steroid hormone. It is a precursor and metabolite of testosterone. 11-ketotestosterone can be used for research purposes in the laboratory.

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Lab products found in correlation

2 protocols using 11 ketotestosterone

Steroid Compounds for Biochemical Assays

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11β-hydroxyandrostenedione (4-androsten-11β-ol-3,17-dione; 11OHA4), 11β-hydroxy-17β-Estradiol (1,3,5(10)-estratrien-3,11β,17β-triol; 11OHE₂), 11β-hydroxytestosterone (4-androsten-11β,17β-diol-3-one; 11OHT), 11-keto androstenedione (4-androsten-3,11-17-trione; 11KA4), 11-ketotestosterone (4-androsten-17β-ol-3,11-dione; 11KT), androstenedione (4-androsten-3,17-dione; A4) and T (4-androsten-17β-ol-3-one; T) were purchased from Steraloids. 17β-Estradiol (1,3,5(10)-estratrien-3, 17β-diol; E₂), bisphenol A (4,4′-(propane-2,2,diyl)diphenol; BPA), estrone (1,3,5(10)-estratien-3-ol-17-one; E₁), fulvestrant (ICI), and letrozole were purchased from Sigma-Aldrich, and 11β-hydroxyandrostenedione 2,2,4,6,6,16,16-D7 (D7- 11OHA4) and T 1,2-D2 (D2-T) were from Cambridge Isotopes. [2,4,6,7-³H(N)]-estradiol ([³H]-E₂) and [1β-³H(N)]-androst-4-ene-3,17-dione ([³H]-A4) were from PerkinElmer Life.

Barnard L., Schiffer L., Louw du-Toit R., Tamblyn J.A., Chen S., Africander D., Arlt W., Foster P.A, & Storbeck K.H. (2020). 11-Oxygenated Estrogens Are a Novel Class of Human Estrogens but Do not Contribute to the Circulating Estrogen Pool. Endocrinology, 162(3), bqaa231.

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Steroid Compound Acquisition and Characterization

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17β-DihydroAndrosterone (5α-androstane-3α,17β-diol; 3α-adiol), Androstanedione (5α- androstane-3,17-dione; 5α-dione), Androstenedione (androstene-3,17-dione; A4), Androsterone (5α-androstan-3α-ol-17-one; AST), 5α-dihydro testosterone (5α-androstan-17β-ol-3-one; DHT), Drospirenone (17-Hydroxy-6β,7β:15β,16β-dimethylene-3-oxo-17α- pregn-4-ene-21 carboxylic acid, DRSP), dutasteride ((5α,17β)-N-[2,5- Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide), gestodene (4,15- estradien-17β-ethynyl-18-homo-17α-ol-3-one, GES), indomethacin (1-(4-Chlorobenzoyl)-5- methoxy-2-methyl-3-indoleacetic acid) and testosterone (4-androsten-17β-ol-3-one; T) were purchased from Sigma Aldrich (St. Louis, USA). 11-KetoAndrostenedione (4-androstene- 3,11,17-trione; 11KA4), 11-ketotestosterone (4-androsten-17β-ol-3,11-dione; 11KT), 11- keto-5α-dihydro testosterone (5α-androstan-17β-ol-3,11-dione; 11KDHT) and 11- ketoAndrosterone (5α-androstan-3α-ol-11,17-dione; 11KAST) were purchased from Steraloids (Wilton, USA). testosterone-1, 2-D2 (T-D2) was purchased from Cambridge Isotope Laboratories (Andover, USA).

Barnard M., Quanson J.L., Mostaghel E., Pretorius E., Snoep J.L, & Storbeck K.H. (2018). 11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): implications for castration resistant prostate cancer.. The Journal of steroid biochemistry and molecular biology, 183, 192-201.

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