For cohorts 1 and 3, single-center 18 F-florbetaben PET data were obtained using an ECAT Exact HR1 scanner (Siemens Healthcare). For cohort 2, multicenter PET data were acquired on 8 different PET scanners with different full widths at half maximum (Table 1). All PET data were corrected for radioactive decay, dead time, attenuation, and scatter. The PET data frames 70-90 min after injection (13) (for cohort 1) or 90-110 min after injection (for cohorts 2 and 3) were combined and reconstructed by standard algorithms.
Ecat exact hr1 scanner
Manufactured by Siemens
The ECAT EXACT HR1 scanner is a high-resolution positron emission tomography (PET) system designed for research applications. It is capable of providing detailed images of the body's physiological processes. The ECAT EXACT HR1 utilizes advanced detector technology to deliver high-quality PET data for scientific investigations.
Automatically generated - may contain errors
Lab products found in correlation
4 protocols using ecat exact hr1 scanner
1
Multi-Center 18F-Florbetaben PET Imaging
2
PET Imaging of Amyloid Deposition
3
PET Imaging of Glucose Metabolism
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Each patient fasted for at least 6 h before PET scanning. Dopaminergic and cholinergic medication was transiently stopped at least 12 h before scanning. PET images were acquired in 3-dimensional mode using a Siemens ECAT EXACT HR1 scanner (CTI). Intravenous injection of 185 MBq of 18 F-FDG was performed with subjects at rest (eyes closed, dimmed ambient light, no movement). A 20-min static acquisition protocol beginning 30 min after injection was used. Transmission scans were obtained for attenuation-correction purposes using a rotating 68 Ge/ 68 Ga source. After corrections for randoms, dead time, and scatter, images were reconstructed with filtered backprojection (Hamm filter, cutoff frequency, 0.5 cycles/projection element) resulting in 60-63 slices in a 128 • 128 matrix (pixel size, 2 mm) and interplane separation of 2.4 mm.
4
Dynamic 18F-DPA-714 PET Imaging Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Structural T1-weighted MR images were acquired for all subjects on an Intera 1.5-T scanner (Philips). Dynamic PET emission scans (90 min) were acquired using an ECAT EXACT HR1 scanner (CTI/ Siemens) after administration of 250 6 10 MBq of 18 F-DPA-714.
Before this emission scan, a transmission scan was acquired for attenuation correction purposes. Dynamic scans were reconstructed into a single dynamic dataset of 33 frames (6 • 5, 3 • 10, 3 • 20, 4 • 60, 6 • 180, and 11 • 360 s) using 2-dimensional filtered backprojection with Fourier rebinning, a Hanning filter (cutoff, 0.5), a matrix size of 256 • 256 • 47, a field of view of 15.7 cm, and a final voxel size of 1.17 • 1.17 • 3.27 mm. All appropriate corrections for dead time, attenuation, scatter, and randoms were applied during reconstruction. In addition, the metabolite-corrected parent plasma input function was measured using an automated arterial blood sampling system (ABSS; Allogg), together with manual blood samples collected at 6 different times (5, 10, 20, 30, 45 , and 60 min after injection). These manual samples were used to estimate plasma-to-whole-blood concentration ratios and labeled metabolite fractions.
Before this emission scan, a transmission scan was acquired for attenuation correction purposes. Dynamic scans were reconstructed into a single dynamic dataset of 33 frames (6 • 5, 3 • 10, 3 • 20, 4 • 60, 6 • 180, and 11 • 360 s) using 2-dimensional filtered backprojection with Fourier rebinning, a Hanning filter (cutoff, 0.5), a matrix size of 256 • 256 • 47, a field of view of 15.7 cm, and a final voxel size of 1.17 • 1.17 • 3.27 mm. All appropriate corrections for dead time, attenuation, scatter, and randoms were applied during reconstruction. In addition, the metabolite-corrected parent plasma input function was measured using an automated arterial blood sampling system (ABSS; Allogg), together with manual blood samples collected at 6 different times (5, 10, 20, 30, 45 , and 60 min after injection). These manual samples were used to estimate plasma-to-whole-blood concentration ratios and labeled metabolite fractions.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!