All participants underwent bilateral implantation of Medtronic 3387 electrodes placed approximately 2mm anterior and parallel to the columns of the fornices. Two weeks after surgery, participants were randomized 1:1 to receive either early stimulation or sham stimulation followed by delayed activation of the implant after 12 months. Participants had clinic visits and safety monitoring one month after implantation and activation (at months 1 and 13), and then every three months. Adverse events were reviewed and adjudicated in real time by a masked internal Clinical Events Committee (CEC), and every 6 months by an unmasked external Data Safety and Monitoring Board.
3387 electrodes
Manufactured by Medtronic
The 3387 electrodes are a type of medical lab equipment used for various diagnostic and research purposes. The core function of these electrodes is to measure electrical signals and activity within the body. They are designed to interface with the body and collect data that can be used for analysis and monitoring. The 3387 electrodes provide a reliable and accurate way to gather this information, but their specific intended use should be determined by healthcare professionals and researchers.
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Lab products found in correlation
2 protocols using 3387 electrodes
1
Bilateral Fornix Stimulation for Neuromodulation
2
Stereotactic Implantation of Thalamic Electrodes for Tremor Suppression
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Surgery was performed under local anaesthesia, using the CRW frame, targeting the thalamus with previously acquired MRI scans fused to a stereotactic CT scan. A more detailed account of the surgical methodology employed has been described previously (Papanastassiou et al., 1998 , Orth et al., 1999) . Bilateral Vim thalamic nuclei were implanted with Medtronic 3387 electrodes and their positions confirmed with stereotactic CT imaging.
The target points were also related to the mid commissural point (MCP) as follows: Vim 12mm lateral and 4mm posterior to the MCP. The implanted electrodes were externalised for a period of trial stimulation using Medtronic test stimulator (ENS), following which the electrodes were internalised and connected to an Activa RC implantable pulse generator (Medtronic Inc.). Optimal lead placement for tremor suppression was achieved with the aid of intraoperative stimulation.
The target points were also related to the mid commissural point (MCP) as follows: Vim 12mm lateral and 4mm posterior to the MCP. The implanted electrodes were externalised for a period of trial stimulation using Medtronic test stimulator (ENS), following which the electrodes were internalised and connected to an Activa RC implantable pulse generator (Medtronic Inc.). Optimal lead placement for tremor suppression was achieved with the aid of intraoperative stimulation.
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