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Ticarcillin clavulanic acid

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Ticarcillin/clavulanic acid is a combination antibiotic used in laboratory settings. It consists of the antibiotic ticarcillin and the beta-lactamase inhibitor clavulanic acid. This combination is effective against a variety of bacteria.

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Lab products found in correlation

Imipenem, by Thermo Fisher Scientific (4 mentions) Piperacillin tazobactam, by Thermo Fisher Scientific (3 mentions) Levofloxacin, by Thermo Fisher Scientific (3 mentions) Minocycline, by Thermo Fisher Scientific (3 mentions) Ticarcillin, by Thermo Fisher Scientific (2 mentions) Ceftriaxone, by Thermo Fisher Scientific (2 mentions) Piperacillin, by Thermo Fisher Scientific (2 mentions) Amikacin, by Thermo Fisher Scientific (2 mentions) Gentamicin, by Thermo Fisher Scientific (2 mentions) Ciprofloxacin, by Thermo Fisher Scientific (2 mentions) Ceftazidime, by Thermo Fisher Scientific (2 mentions) Amoxicillin, by Thermo Fisher Scientific (1 mentions) Muller hinton agar, by Thermo Fisher Scientific (1 mentions) Cefoperazone, by Thermo Fisher Scientific (1 mentions) Cefoxitin, by Thermo Fisher Scientific (1 mentions) Amoxicillin clavulanic acid, by Thermo Fisher Scientific (1 mentions) Ampicillin sulbactam, by Thermo Fisher Scientific (1 mentions) Ampicillin, by Thermo Fisher Scientific (1 mentions) Tobramycin, by Thermo Fisher Scientific (1 mentions) Cefepime, by Thermo Fisher Scientific (1 mentions)

Spelling variants of this product

Clavulanic acid (16 citations) Ticarcillin (7 citations)

5 protocols using ticarcillin clavulanic acid

1

Antimicrobial Susceptibility Testing of Bacteria

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The antimicrobial sensitivity profile of recovered bacteria was determined using the disk diffusion assay on Muller-Hinton agar (MH; Oxoid, Cheshire, UK) according to the standards and interpretive criteria described by the Clinical and Laboratory Standards Institute guidelines (CLSI, 2014 ). The strains were tested for susceptibility to a panel of antibiotics (Oxoid, UK): amoxicillin (AML10), amoxicillin/clavulanic acid (AMC30), ticarcillin (TIC75), ticarcillin/clavulanic acid (TIM85), piperacillin (PRL100), piperacillin/tazobactam (TZP110), cephalothin (KF30), cefoxitin (FOX30), ceftriaxone (CRO30), cefoperazone (CFP30), ceftazidime (CAZ30), cefotaxime (CTX30), cefepime (FEP30), imipenem (IPM10), aztreonam (ATM30), streptomycin (S10), kanamycin (K30), amikacin (AK30), gentamicin (CN10), tobramycin (TOB10), nalidixic acid (NA30), ciprofloxacin (CIP5), erythromycin (E15), tetracycline (TE30), trimethoprim-sulfamethoxazole (SXT25), chloramphenicol (C30) and fosfomycin (FOS50).
Dias C., Borges A., Oliveira D., Martinez-Murcia A., Saavedra M.J, & Simões M. (2018). Biofilms and antibiotic susceptibility of multidrug-resistant bacteria from wild animals. PeerJ, 6, e4974.
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2

Antimicrobial Susceptibility Evaluation

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The disk diffusion method was used to evaluate susceptibility to the following antimicrobial agents: imipenem (IPM: 10 μg), ceftazidime (CAZ: 30 μg), amikacin (AMK: 30 μg), piperacillin/tazobactam (TZP: 100/10 μg), levofloxacin (LVX: 5 μg), ticarcillin/Clavulanic acid (TCC: 75/10 μg), minocycline (MNO: 30 μg) (Oxoid, UK). Results were interpreted in accordance with CLSI guidelines from 2011. Isolates with intermediate susceptibility were classified as non-susceptible.
Ning N.Z., Liu X., Bao C.M., Chen S.M., Cui E.B., zhang J.L., Huang J., Chen F.H., Li T., Qu F, & Wang H. (2017). Molecular epidemiology of blaOXA-23-producing carbapenem-resistant Acinetobacter baumannii in a single institution over a 65-month period in north China. BMC Infectious Diseases, 17, 14.
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3

Antimicrobial Susceptibility Testing of Acinetobacter baumannii

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Antimicrobial susceptibility testing of the isolated strains was performed according to the Clinical and Laboratory Standards Institute guidelines (CLSI, 2016) using the disc diffusion method. We tested the susceptibility of the isolates to piperacillin, ampicillin, ampicillin-sulbactam, piperacillin-tazobactam, ticarcillin-clavulanic acid, ceftazidime, cefepime, cefotaxime, ceftriaxone, imipenem, meropenem, gentamicin, tobramycin, amikacin, minocycline, ciprofloxacin, levofloxacin, and polymyxin B discs (Oxoid, UK). The drug susceptibility data for the A. baumannii isolates were analyzed using WHONET 5.6. Multi-drug resistance for A. baumannii isolates was defined as described previously.1 (link)
Tang J., Chen Y., Wang X., Ding Y., Sun X, & Ni Z. (2020). Contribution of the AbaI/AbaR Quorum Sensing System to Resistance and Virulence of Acinetobacter baumannii Clinical Strains. Infection and Drug Resistance, 13, 4273-4281.
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4

Antibiotic Susceptibility Profiling of Isolates

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The isolates’ antibiotic susceptibility profile was determined using the disk diffusion method on Mueller-Hinton Agar (MH) according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines [29 (link),30 ]. The selection of antibiotic and disk concentrations was based on the EUCAST recommendations for the genera of the isolates. The antibiotics tested were the following: aztreonam (ATM; 30 mg), cefepime (FEP; 30 mg), ceftazidime (CAZ; 10 mg), chloramphenicol (C; 30 mg), ciprofloxacin (CIP; 5 mg), gentamicin (CN; 10 mg), imipenem (IMI; 10 mg), ticarcillin (TIC; 75 mg), ticarcillin/clavulanic acid (TIM; 75 mg TIC + 10 mg clavulanic acid), tigecycline (TGC; 15 mg) and trimethoprim/sulfamethoxazole (STX; 25 mg) (Oxoid, Basingstoke, UK). The reference strain used for quality control was the Escherichia coli ATCC 25922. Plates were incubated at 30 °C for 18 h and the inhibition zone diameters were measured. Isolates were then classified as “susceptible, standard dose” (S), “susceptible, increased exposure” (I) or “resistant” (R) according to EUCAST expert rules and CLSI breakpoint tables for the gentamicin [30 ,31 ].
Almeida A.R., Tacão M., Soares J., Domingues I, & Henriques I. (2021). Tetracycline-Resistant Bacteria Selected from Water and Zebrafish after Antibiotic Exposure. International Journal of Environmental Research and Public Health, 18(6), 3218.
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5

Antibiotic Susceptibility Testing Protocol

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Mueller-Hinton (MH) agar medium was purchased from Guangzhou Dijing Microbiology Co., Ltd.. Drug sensitivity test paper (combining sulfamethoxazole, SXT; minocycline, MH; levofloxacin, LVX; ticarcillin/clavulanic acid, TIM; ceftazidime, CAZ; chloramphenicol, CL and imipenem, IPM) was purchased from OXOID (United Kingdom).
Liu B, & Tong S. (2019). An investigation of Stenotrophomonas maltophilia-positive culture caused by fiberoptic bronchoscope contamination. BMC Infectious Diseases, 19, 1072.
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