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Vycril 5 0

Manufactured by Johnson & Johnson
Sourced in United States

Vycril 5-0 is a sterile, synthetic, absorbable surgical suture material composed of a copolymer of glycolide and epsilon-caprolactone. It is designed for use in soft tissue approximation and ligation, including use in ophthalmic procedures.

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2 protocols using vycril 5 0

1

Spinal Cord Contusion Injury in Rats

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Rats received a moderate (12.5 g-cm) thoracic (T10) spinal cord contusion delivered by the New York University Impactor as described previously (Magnuson et al., 2009 (link)). Briefly, surgical procedures were carried out under Pentobarbital (IP, 50 mg/Kg) anesthesia and all animals received prophylactic antibiotics (Gentamicin, 15mg/Kg sc). Once anaesthetized, the surgical site was shaved and disinfected with chlorhexadine digluconate (Sigma-Aldrich, St. Louis, MO). The eyes were protected with Lacri-lube (Allergan, Irvine, CA). A midline dorsal skin incision was made exposing the thoracic and upper lumbar spinal column and the muscles were dissected to expose the vertebral laminae from T8 to T11. This was followed by a laminectomy of the T9 vertebra and, following securing the vertebral column with clamps at T8 and T10, delivery of the contusion to the T10 spinal cord leaving the dura intact. Muscles were sutured with vycril 5-0 (Ethicon Endo-Surgery, Blue Ash, OH) and the skin was closed with stainless steel staples. After the surgery, the rats were given 0.05 mg/kg of buprenorphine (Henry Schein, Indianapolis, IN, USA) and 5.0 ml of saline. This was followed up by a 0.03 mg/kg dose of buprenorphine 8 hrs later and additional saline if the animals showed signs of dehydration.
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2

Calvarial Defect Repair in Rat Model

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After general anesthetization with a mixture of ketamine 35 mg/kg and xylazine 5 mg/kg, the dorsal part of the scalp covering the calvarias was shaved and disinfected with iodophor gauze. A dermoperiosteal incision was made along the midline of the cranium from the frontal bone to the occipital bone. A full-thickness flap was elevated to expose the surgical area. Two 10-mm-diameter calvarial defects were created on both sides of the midline using a trephine bur under profuse saline irrigation. The resected bone blocks were carefully removed, and the defects were treated as described in Section 4.3.1. Then, the periosteum and scalp skin were sutured in layers with polylactic acid sutures (Vycril 5.0, Ethicon, Raritan, NJ, USA) and nylon monofilament sutures (ETHILON® Nylon Suture, Ethicon, Raritan, NJ, USA). The animals were intramuscularly injected with antibiotics two times daily for 3 days.
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