Haloperidol, trazodone, bromocriptine, and ketanserin were purchased from Sigma-Aldrich Inc. (St. Louis, MO, USA).
Trazodone
Manufactured by Merck Group
Sourced in United States, Italy
Trazodone is a laboratory equipment product manufactured by Merck Group. It is a chemical compound that functions as a serotonin antagonist and reuptake inhibitor.
Automatically generated - may contain errors
Lab products found in correlation
Alprazolam, by Merck Group (3 mentions)
Haloperidol, by Merck Group (2 mentions)
Buspirone, by Merck Group (2 mentions)
Bupropion, by Merck Group (2 mentions)
Clomipramine, by Merck Group (2 mentions)
Methanol, by Thermo Fisher Scientific (2 mentions)
Bromocriptine, by Merck Group (1 mentions)
Ketanserin, by Merck Group (1 mentions)
Salubrinal, by Merck Group (1 mentions)
Nefazodone, by Merck Group (1 mentions)
Dimethysulfoxide, by Merck Group (1 mentions)
Williams e medium, by Merck Group (1 mentions)
Penicillin, by Merck Group (1 mentions)
Streptomycin, by Merck Group (1 mentions)
Sb203580, by LC Laboratories (1 mentions)
Pd184352, by LC Laboratories (1 mentions)
Sp600125, by LC Laboratories (1 mentions)
Fetal bovine serum (fbs), by Atlanta Biologicals (1 mentions)
Dextrorphan, by Merck Group (1 mentions)
Phenacetin, by Merck Group (1 mentions)
12 protocols using trazodone
1
Neuropharmacological Agents Evaluation
2
Cell Signaling Pathway Modulation
3
Analytical Method for Drug Metabolites
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Phenacetin, acetaminophen, 2-acetamidophenol, coumarin, 7-hydroxy-comuarin (umbelliferone), flurbiprofen, dextromethorphan, dextrorphan, trazodone, thymol, bupropion, 6-hydroxy-bupropion, alprazolam, 1′-hydroxy-alprazolam, NADP+, isocitrate dehydrogenase, and DL-isocitrate were purchased from Sigma-Aldrich (St. Louis, MO, USA). Pronethalol was from Tocris (Minneapolis, MN, USA). Propofol was provided by Zeneca Pharmaceuticals (Wilmington, DE, USA). 4′-hydroxy-flurbiprofen, 2-fluoro-4-biphenyl-acetic acid, 4-hydroxy-propofol, chlorzoxazone, and 6-hydroxy-chlorzoxazone were purchased from Toronto Research Chemicals (Toronto, ON, Canada). S-Mephenytoin and 4-hydroxymephenytoin were purchased from Gentest (Corning, Corning, NY, USA). GW340416A, a chemical analogue of bupropion, was kindly provided by GlaxoSmithKline (Research Triangle Park, NC, USA). Omeprazole was purchased from BeanTown Chemical, Inc. (Hudson, NH, USA) and omeprazole sulfone was purchased from Cayman Chemical Company (Ann Arbor, MI, USA). Sodium hydroxide, potassium phosphate monobasic and potassium phosphate dibasic and EDTA were purchased from J.T. Baker (Center Valley, PA, USA). HPLC-grade acetonitrile and methanol were purchased from Thermo Fisher Scientific (Waltham, MA, USA). Ultra-pure water was obtained using a Milli-Q® Q-POD Millipore System (EMD Millipore, Burlington, MA, USA).
4
Radiolabeled Aspartate Binding Assay
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
[2,3-3H]D-aspartate (specific activity 11.3 Ci/mmol) was from Perkin Elmer (NET581001MC, Boston, MA, USA). LY379268 was purchased from Tocris Bioscience (2453, Bristol, UK). (±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride, (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride [(±) DOI], MDL11,939, ketamine, and trazodone were purchased from Sigma (Milan, Italy).
5
Haloperidol and Trazodone Pharmacology
6
Analytical Standards Procurement Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Caffeine, tramadol, irbesartan, diclofenac and trazodone (99.5%) were purchased from Sigma-Aldrich (Milan, Italy). All the other chemicals and solvents were purchased from Fluka (Saint-Quentin Fallavier, France) with HPLC grade and were used as received. Double distilled water (Microtech, Naples, Italy) was used to prepare the drug solutions.
7
Antidepressants and Ketamine Behaviors
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Male C57BL/6 mice (age, 3–4 months) received daily intraperitoneal injections of fluoxetine (10 mg/kg; Sigma-Aldrich) for 10 d. Clomipramine (10 mg/kg; Sigma-Aldrich), trazodone (40 mg/kg; Sigma-Aldrich), or an equivalent volume of saline was administered for 14 d. For ketamine, a single intraperitoneal injection (3 mg/kg; Syntec) was performed 3 h before killing. All drugs were diluted in sterile saline solution before injection.
8
Determination of Imatinib Plasma Levels
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The determination of the IM plasma concentrations followed the protocol as described in Ubhayasekhera et al. [25 (link)]. IM standard was kindly provided by Novartis (Basel, Switzerland). All chemicals including internal standard (Trazodone) and ultrapure solvents were purchased from Sigma Aldrich (Stockholm, Sweden), unless otherwise stated. The stock solutions of IM and internal standard were prepared by dissolving methanol to obtain a final concentration of 1 mg/mL. Protein precipitation was applied as a sample pretreatment. Twenty-five microliter of methanol containing 1 µg/mL internal standard and 0.5 mL of methanol were added to 100 µL of plasma, shaken in 10 min and centrifuged for 10 min at 4 °C at 14,000g. The supernatant was dried by vacuum centrifugation and the residue was reconstituted in 100 µL of 5% acetonitrile containing 0.1% formic acid. Aliquouts of 10 µL were injected into the LC–MS system. Chromatography and mass spectrometry was performed as previously described [25 (link), 26 (link)].
9
Serotonin Effects on Tadpole Color Preference
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
For chronic exposure of tadpoles to the selective serotonin reuptake inhibitor (SSRI) trazodone, either 1 μM or 10 μM of trazodone hydrochloride (Sigma–Aldrich, catalog # T6154) was added to their Steinberg’s rearing solution from developmental stage 43 (approximately 4 dpf) until they were tested for color preferences (stage 48/49, approximately 13–18 dpf). The rearing solution for all groups was replaced every 48 h until completion of the experiment. To observe the acute effects of trazodone, tadpoles were exposed to the same concentrations only 24 h before testing. In both the acute and chronic experiments, 10 tadpoles from each group underwent 30-min trials on a green vs. white and green vs. black assay over 2 days.
10
Analytical Standards for Neuropharmacological Compounds
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Sample preparation was performed with analytical grade solvents obtained from Merck KGaA (Darmstadt, Germany). LC-MS grade acetonitrile for the mobile phase was obtained from Fisher Scientific GmbH (Schwerte, Germany), and water and formic acid (99% purity) were purchased from Acros Organics (Geel, Belgium). The following deuterated standards (99% purity) were purchased from LGC Standards GmbH (Wesel, Germany): 6 Furthermore, the following standards (99% purity) were purchased from LGC Standards GmbH (Wesel, Germany) or Sigma Aldrich (St. Louis, MO): 7-aminoflunitrazepam, alprazolam, amisulpride, amitriptyline, aripiprazole, benperidol, bromazepam, bupropion, chlorpromazine, chlorprothixene, citalopram, clomipramine, clonazepam, clozapine, diazepam, doxepin, flunitrazepam, fluoxetine, fluphenazine, flupentixol, f l u v o x a m i n e , h a l o p e r i d o l , h y d r o x y r i s p e r i d o n e , levomepromazine, maprotiline, melperone, methylphenidate, mianserin, midazolam, mirtazapine, norcitalopram, norclomipramine, norclozapine, nordiazepam, nordoxepin, nortriptyline, norvenlafaxine, olanzapine, opipramol, oxazepam, paroxetine, pipamperone, promethazine, quetiapine, sulpiride, temazepam, trazodone, trimipramine, venlafaxine, and zuclopenthixol. A standard mixture containing 10 ng/μL of each analyte in methanol was prepared and diluted as required.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!