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Nod cb17 prkdcscid j nod scid

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The NOD.CB17-Prkdcscid/J (NOD/SCID) is a laboratory mouse strain that is highly immunodeficient. It lacks functional T cells, B cells, and natural killer cells, making it a useful model for studying human immune system-related research.

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C57bl 6, by Jackson ImmunoResearch (2 mentions) Nor ltj, by Jackson ImmunoResearch (1 mentions) Female nod shiltj, by Jackson ImmunoResearch (1 mentions) C57bl 6j b6, by Jackson ImmunoResearch (1 mentions) C57bl 6j tyrc2j, by Jackson ImmunoResearch (1 mentions) Fvb nj, by Jackson ImmunoResearch (1 mentions) Cba j, by Jackson ImmunoResearch (1 mentions) Balb cbyj balb c, by Jackson ImmunoResearch (1 mentions) R26 smo m2, by Jackson ImmunoResearch (1 mentions)

8 protocols using nod cb17 prkdcscid j nod scid

1

Murine Models for Cancer Research

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C57BL6, NOD/CB17-Prkdcscid/J (NOD/SCID) and p16p19nullmice (B6.129 background) mice were obtained from Jackson Laboratory and the National Institutes of Health/Mouse Models of Human Cancer Consortium, respectively. Mice were bred and maintained at the Joslin Diabetes Center Animal Facility. All animal experiments were approved by the Joslin Diabetes Center Institutional Animal Care and Use Committee.
Hettmer S., Schinzel A.C., Tchessalova D., Schneider M., Parker C.L., Bronson R.T., Richards N.G., Hahn W.C, & Wagers A.J. (2015). Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma. eLife, 4, e09436.
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2

Murine Models for Immunological Studies

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Female NOD/ShiLtJ (NOD), NOD.CB17-Prkdcscid/J (NOD.Scid), NOR/LtJ, NOD.BDC2.5 (BDC2.5), and C57BL/6J (B6) mice were purchased from The Jackson Laboratory (Bar Harbor, ME). Human CD20 transgenic NOD mice [hCD20(+/+) NOD] were generated and maintained as previously reported (15 (link)). All mice were used according to institutional guidelines, and animal protocols were approved by the Boston Children’s Hospital Institutional Animal Care and Use Committee.
Kleffel S., Vergani A., Tezza S., Ben Nasr M., Niewczas M.A., Wong S., Bassi R., D’Addio F., Schatton T., Abdi R., Atkinson M., Sayegh M.H., Wen L., Wasserfall C.H., O’Connor K.C, & Fiorina P. (2014). Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens. Diabetes, 64(1), 158-171.
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3

Preclinical Mouse Models for Drug Studies

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The Animal Care and Use Committee of Baylor Scott & White approved all the animal protocols used in the study. Male NOD.CB17-Prkdcscid/J (NOD/SCID) and MDR2−/− (FVB.129P2) mice (25–30 gm, 6 to 12 wks of age), were obtained from Jackson Laboratories (Bar Harbor, ME).
McDaniel K., Meng F., Wu N., Sato K., Venter J., Bernuzzi F., Invernizzi P., Zhou T., Kyritsi K., Wan Y., Huang Q., Onori P., Francis H., Gaudio E., Glaser S, & Alpini G. (2016). Forkhead box A2 regulated biliary heterogeneity and senescence during cholestatic liver injury. Hepatology (Baltimore, Md.), 65(2), 544-559.
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4

Mouse Strains for Immunology Research

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Eight to twelve week old female and male C57BL/6, albino B6.C57BL/6J-Tyr
c-2J, C.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ, FVB/NJ and NOD.CB17-Prkdcscid/J
(NOD SCID) mice were purchased from Jackson Laboratories (Bar Harbor, ME).
NKG2D−/− mice (23 (link)) were
kindly provided by David Raulet (UC Berkeley). The Stanford University
Administrative Panel on Laboratory Animal Care approved all protocols used in
this study.
Cisneros T., Dillard D.W., Qu X., Arredondo-Guerrero J., Castro M., Schaffert S., Martin R., Esquivel C.O., Krams S.M, & Martinez O.M. (2019). Differential role of natural killer group 2D in recognition and cytotoxicity of hepatocyte-like cells derived from embryonic stem cells and induced pluripotent stem cells. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 19(6), 1652-1662.
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5

Procurement and Housing of Experimental Mice

Cited 1 time
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All the mice required during different experiments (NOD.CB17-Prkdcscid/J (NOD SCID), CBA/J and BALB/cByJ (BALB/c) were procured from the Jackson Laboratory, USA while the NOD-SCID-rd1 mouse model was developed in-house as reported previously [20 (link)]. The animals received ad libitum access to acidified autoclaved water and food. The temperature and humidity of the housing room was maintained at 21–23 °C and 40–60% respectively. Animals were kept at a 14-h light to 10-h dark cycle. Animals were randomly assigned in each group, and experiments were repeated at least twice. All animal experiments and reporting adhere to the ARRIVE guidelines [21 (link)].
Mishra A., Mohan K.V., Nagarajan P., Iyer S., Kesarwani A., Nath M., Moksha L., Bhattacharjee J., Das B., Jain K., Sahu P., Sinha P., Velapandian T, & Upadhyay P. (2020). Peripheral blood-derived monocytes show neuronal properties and integration in immune-deficient rd1 mouse model upon phenotypic differentiation and induction with retinal growth factors. Stem Cell Research & Therapy, 11, 412.
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6

Generating Mouse Models for Research

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R26-SmoM2 (mixed genetic background including 129/Sv and Swiss Webster as main components) (11 (link)), CAGGS-CreER (11 (link)), and NOD.CB17-Prkdcscid/J (NOD.SCID) mice were purchased from The Jackson Laboratory. p16p19null mice (B6.129 background) were obtained from the NIH/Mouse Models of Human Cancer Consortium. Mice were bred and maintained at the Joslin Diabetes Center Animal Facility. All animal experiments were approved by the Joslin Diabetes Center Institutional Animal Care and Use Committee.
Hettmer S., Bronson R.T, & Wagers A.J. (2015). Distinct Malignant Behaviors of Mouse Myogenic Tumors Induced by Different Oncogenetic Lesions. Frontiers in Oncology, 5, 50.
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7

Xenograft Tumor Model in Mice

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NOD.CB17-Prkdcscid/J (NOD/SCID) (Jackson Laboratory), five to six weeks old male mice were anesthetized using ketamine and xylazine (50mg/kg and 5mg/kg, respectively) cocktail injected intraperitoneally. 22RV1-DLX1-KO and 22RV1-SCR control cells (2×10 6 for each group) were suspended in 100μl of saline with 20% Matrigel and implanted subcutaneously at the dorsal both flank sides of mice (n=6 for each condition), and tumor burden was measured using digital Vernier caliper on alternate days. Further, tumor volume was calculated using formula (π/6) (L × W 2 ), (L=length; W=width).
Goel S., Bhatia V., Carskadon S., Gupta N., Asim M., Palanisamy N., & Ateeq B. (2020). Transcriptional network involving ERG and AR orchestrates Distal-Less Homeobox 1 mediated prostate cancer progression.
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8

Xenograft Tumor Model in Mice

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NOD.CB17-Prkdcscid/J (NOD/SCID) (Jackson Laboratory), five to six weeks old male mice were anesthetized using ketamine and xylazine (50mg/kg and 5mg/kg, respectively) cocktail injected intraperitoneally. 22RV1-DLX1-KO and 22RV1-SCR control cells (2×10 6 for each group) were suspended in 100μl of saline with 20% Matrigel and implanted subcutaneously at the dorsal both flank sides of mice (n=6 for each condition), and tumor burden was measured using digital Vernier caliper on alternate days. Further, tumor volume was calculated using formula (π/6) (L × W 2 ), (L=length; W=width).
Goel S., Bhatia V., Carskadon S., Gupta N., Asim M., Palanisamy N., & Ateeq B. (2020). Transcriptional network involving ERG and AR orchestrates Distal-Less Homeobox 1 mediated prostate cancer progression.
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