Naloxonazine

Manufactured by Merck Group

Sourced in United States

Naloxonazine is a laboratory reagent used in research applications. It is a synthetic compound that acts as an opioid antagonist, blocking the effects of opioid drugs. Naloxonazine is commonly used in experimental studies to investigate the pharmacological mechanisms and functions of opioid receptors in biological systems.

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Lab products found in correlation

5 fluorouracil, by Merck Group (1 mentions) Diazepam, by Merck Group (1 mentions) Dimethyl sulfoxide (dmso), by Mallinckrodt (1 mentions) Morphine hydrochloride, by Merck Group (1 mentions) Naloxone hydrochloride, by Cristália (1 mentions) Formaldehyde 37, by Vetec (1 mentions)

2 protocols using naloxonazine

Pharmacological Agents in Research

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The following drugs and reagents were acquired in Sigma-Aldrich® (St. Louis, MO, United States): 5-fluorouracil (5-FU), diazepam, naloxonazine, cyclophosphamide, and Tween 80. The anesthetics ketamine and xylazine were obtained from Konig S.A. (Brazil), and MSD Saúde Animal (Brazil), respectively. Other drugs, reagents, and kits comprise: heparin (HEPAMAXS®), ELISA Kit (eBioscience®, Inc. Science Center Drive, San Diego, CA, United States), kits for hematological and biochemical analysis (LABTEST; Lagoa Santa, MG, Brazil), morphine hydrochloride (Merck®), naloxone hydrochloride (Cristália®), formaldehyde 37% (Vetec), dimethylsulfoxide - DMSO (Mallinckrodt Chemicals - Phillipsburg, NJ, United States). The acridine derivative N’-(6-chloro-2-methoxy-acridin-9-yl)-2-cyanoacetohydrazide (ACS-AZ) was synthesized as previously described (Silva et al., 2018 (link)).

Mangueira V.M., de Sousa T.K., Batista T.M., de Abrantes R.A., Moura A.P., Ferreira R.C., de Almeida R.N., Braga R.M., Leite F.C., Medeiros K.C., Cavalcanti M.A., Moura R.O., Silvestre G.F., Batista L.M, & Sobral M.V. (2022). A 9-aminoacridine derivative induces growth inhibition of Ehrlich ascites carcinoma cells and antinociceptive effect in mice. Frontiers in Pharmacology, 13, 963736.

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Naloxonazine Effects on Serum Iron

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Naloxonazine (Sigma-Aldrich, CAS No. 880759-65-9) (an irreversibly binding MOR antagonist) was injected into twelve WT male mice intraperitoneally at 20 mg/kg. The other nine WT male mice received saline injection as control. The average for the mice was three months. After seven consecutive days of injections, mice were sacrificed on the eighth day, and their serums were collected. Serum iron, ferritin, and transferrin were measured as described above.

Lyu S., DeAndrade M.P., Unger E.L., Mueller S., Oksche A., Walters A.S, & Li Y. (2020). Mu opioid receptor knockout mouse: phenotypes with implications on restless legs syndrome. Journal of neuroscience research, 98(8), 1532-1548.

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