MRI acquisition was performed on a 3T MRI system at our MS center (Achieva TX system, Philips Healthcare, Best, The Netherlands; Signa, GE Healthcare, Discovery MR 750w, Milwaukee, Wisconsin). Seventeen patients (out of 46, i.e., 37%) were not scanned on the same machine at baseline and after 1 year (Philips Achieva at baseline and GE Discovery after 1 year). The acquisition protocol was harmonized between magnets and consisted of a three-dimensional (3D) T1-weighted sequence using magnetization prepared rapid gradient echo (MP-RAGE) imaging (TR = 8.2 ms, TE = 3.5 ms, TI = 982 ms, α = 7°, FOV = 256 mm, voxel size = 1 mm3, 180 slices), a two-dimensional (2D) FLAIR sequence (TR = 11000 ms, TE = 140 ms, TI = 2800 ms, FOV = 230 mm, 45 axial slices, 3-mm thick) and a diffusion tensor echo-planar-imaging (EPI) pulse sequence (TR = 11676 ms, TE = 60 ms, FOV = 230 mm, an isotropic resolution of 1.6 × 1.6 × 1.6 mm3 and b = 1000 s/mm2) in 21 non-colinear directions and one b = 0 s/mm2.
Achieva tx system
Manufactured by Philips
The Achieva TX system is a magnetic resonance imaging (MRI) scanner developed by Philips. It is designed to provide high-quality medical images for diagnostic and clinical purposes. The core function of the Achieva TX system is to generate detailed images of the human body using strong magnetic fields and radio waves, allowing healthcare professionals to assess and diagnose various medical conditions.
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8 protocols using achieva tx system
1
Multi-modal MRI Protocol for MS
2
Multimodal Neuroimaging of Brain Function
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Imaging was performed using 3 Tesla MRI systems (Achieva TX system, Philips Healthcare, Best, The Netherlands; Signa, GE Healthcare, Discovery MR 750w, Milwaukee, Wisconsin). Structural images were acquired with a 3D T1-weighted sequence using magnetization prepared rapid gradient echo (MP-RAGE) imaging (TR = 8.2 ms, TE = 3.5 ms, TI = 982 ms, α = 7°, FOV = 256 mm, voxel size = 1 mm3, and 180 slices) as well as a 2D FLAIR sequence (TR = 11,000 ms, TE = 140 ms, TI = 2,800 ms, FOV = 230 mm, 45 axial slices, and 3-mm thick). Diffusion images were acquired with a diffusion tensor echo-planar-imaging pulse sequence (TR = 11,676 ms, TE = 60 ms, FOV = 230 mm, voxel size = 1.6 mm3) in 21 non-colinear directions at b = 1,000 s/mm2, and with one b = 0 s/mm2. Finally, resting-state functional images were acquired with a whole-brain T2*-weighted echo-planar imaging (EPI) sequence (250 volumes, 40 axial slices, TR = 2,200 ms, TE = 30 ms, voxel size = 3 mm3). The first four volumes of the functional run were removed to reach signal stability.
3
Cardiac MRI Protocol for T1 Mapping
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All studies were performed on a 3‐T Achieva TX system equipped with a 32‐channel cardiac phased array receiver coil and multitransmit technology (Philips Healthcare, Best, the Netherlands). The cardiac long and short axes were determined using standard scout views. Mid LV native (precontrast) T1 maps were generated using a previously described modified look locker inversion recovery sequence,24 briefly comprising the following: ECG (electrocardiogram)‐triggered 5b(3s)3b modified look locker inversion recovery, flip angle of 35°, and voxel size of 1.98×1.98×10 mm3. LV mass and volumes were obtained from cine imaging covering the entire LV in the short axis. Right ventricular and atrial volumes were obtained from a transaxial cine stack covering the entire heart. A total of 0.15 mmol/kg gadobutrol (Gadovist; Bayer) was delivered by power injector (Medrad Inc, Warrendale, PA) as a single bolus via a venous cannula placed in the antecubital fossa, followed by a 20‐mL saline flush at 5 mL/s. Late gadolinium enhancement imaging was performed to image the entire LV 7 to 10 minutes after contrast administration. Postcontrast T1 maps were acquired using the same modified look locker inversion recovery scheme 15 minutes after contrast administration.
4
Cardiac MRI in Acute STEMI Patients
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The study protocol was approved by the institutional research ethics committee and complied with the Declaration of Helsinki (NIHR 33963, REC 17/YH/0062). Patients with a first STEMI were prospectively recruited from a single center between 2019 and 2020 and underwent serial cardiac MR at 1 week and 3 months following their index presentation. Study inclusion criteria were 1) acute STEMI as defined by current international guidelines,9 2) revascularization via PPCI within 12 hours after onset of symptoms, and 3) no contraindications to cardiac MR. Exclusion criteria were 1) previous revascularization procedure (coronary artery bypass grafting or PPCI), 2) known cardiomyopathy, 3) severe valvular heart disease, 4) atrial fibrillation, and 5) hemodynamic instability lasting longer than 24 hours following PCI. Acute clinical management followed contemporary guidelines.
Cardiac MRI examinations were performed on a 3.0 T Philips Achieva TX system (Philips, Best, The Netherlands) equipped with a 32‐channel cardiac phased array receiver coil, MultiTransmit technology and high‐performance gradients with Gmax = 80mT/m and slew rate = 100 mT/m/msec.
Cardiac MRI examinations were performed on a 3.0 T Philips Achieva TX system (Philips, Best, The Netherlands) equipped with a 32‐channel cardiac phased array receiver coil, MultiTransmit technology and high‐performance gradients with Gmax = 80mT/m and slew rate = 100 mT/m/msec.
5
Multimodal Neuroimaging Protocol for Brain Analysis
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A 3 T Philips Achieva-TX system (Best, The Netherlands) from the IRMaGe MRI facility (Grenoble, France) with a 32-channel head coil was used for MRI scanning. The protocol included an anatomical T1-weighted sequence and a 15 min-long high angular resolution diffusion-weighted sequence.
The spin-echo diffusion-weighted sequence included 70 axial slices of 2 mm thickness with in-plane spatial resolution of 1.67 mm2, and a SENSE factor 2 was applied in the antero-posterior direction. 60 diffusion images were acquired with different gradient orientations at b = 1000 s/mm2 as well as one image at b = 0 s/mm2. The repetition and echo times (TR/TE) were set to minimum with actual values 5500/72 ms. The total sequence duration was 15:08 min.
The 3D-T1 MPRAGE (Magnetization Prepared Rapid Acquisition Gradient Echo) anatomical acquisition was the same for all participants, with following parameters: 150 axial slices, voxel size = 0.9*0.9*1.2 mm3, TI = 800 ms, TR = 25 ms, TE = 3.9 ms, flip angle = 15° and acceleration factor = 2.2.
The spin-echo diffusion-weighted sequence included 70 axial slices of 2 mm thickness with in-plane spatial resolution of 1.67 mm2, and a SENSE factor 2 was applied in the antero-posterior direction. 60 diffusion images were acquired with different gradient orientations at b = 1000 s/mm2 as well as one image at b = 0 s/mm2. The repetition and echo times (TR/TE) were set to minimum with actual values 5500/72 ms. The total sequence duration was 15:08 min.
The 3D-T1 MPRAGE (Magnetization Prepared Rapid Acquisition Gradient Echo) anatomical acquisition was the same for all participants, with following parameters: 150 axial slices, voxel size = 0.9*0.9*1.2 mm3, TI = 800 ms, TR = 25 ms, TE = 3.9 ms, flip angle = 15° and acceleration factor = 2.2.
6
3T MRI Structural and Diffusion Imaging Protocol
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MRI scans were performed on a 3T Achieva TX system (Philips Healthcare, Best, The Netherlands) with an 8-channel coil. The morphological protocol consisted of 3D T1 weighted MR images acquired using the magnetization prepared rapid gradient echo (MPRAGE) imaging (TR = 8.20 ms, TE = 3.5 ms, TI = 982 ms, α = 7°, FOV = 256 mm, voxel size = 1 mm3, 180 slices) and Fast Fluid-Attenuated Inversion-Recovery (FLAIR) images (TR = 11000 ms, TE = 140 ms, TI = 2800 ms, FOV = 230 mm, matrix = 325X352, 45 axial slices, 3-mm thick). The single-shot diffusion weighted EPI DTI sequence included 20 directions (TE = 60 ms, TR = 11676 ms, matrix = 144X144, 75 slices, 1.6-mm thickness, b = 1000 s/mm2).
7
Harmonized 3T MRI Acquisition Protocol
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The MRI acquisition was performed on a 3T MRI system (Achieva TX system, Philips Healthcare, Best, The Netherlands; Signa, GE Healthcare, Discovery MR 750w, Milwaukee, Wisconsin). The acquisition protocol was harmonized between the magnets and consisted of a three-dimensional (3D) T1-weighted sequence using magnetization prepared rapid gradient echo (MP-RAGE) imaging, a two-dimensional (2D) FLAIR sequence, and resting-state functional MRI was obtained with an echo-planar imaging (EPI) sequence. See supplementary material for technical details.
8
Structural Brain MRI Acquisition Protocol
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MRI scans were performed on a 3T Achieva TX system (Philips Healthcare, Best, The Netherlands) with an 8-channel phased array head coil. A morphological protocol consisted of: 3D T1 weighted MR images acquired using magnetization prepared rapid gradient echo (MPRAGE) imaging (TR= 8.2ms, TE= 3.5ms, TI= 982ms, α=7°, FOV= 256mm, voxel size=1mm 3 , 180 slices) and 2D multi-slice FLAIR images (TR= 11000ms, TE= 140ms, TI= 2800ms, FOV= 230mm, 45 axial slices, 3 mm thick).
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