Neurofilament light

Manufactured by UmanDiagnostics

Sourced in Sweden

Neurofilament-light is a biomarker that can be measured in the blood or cerebrospinal fluid. It is a structural protein found in neurons and is released into the bloodstream or cerebrospinal fluid when neurons are damaged or degenerate. Measuring the levels of neurofilament-light can provide information about neurological conditions and neuronal health.

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Lab products found in correlation

Aβ1 42, by Thermo Fisher Scientific (1 mentions) Trem2, by Abcam (1 mentions) Brain derived neurotrophic factor (bdnf), by Abcam (1 mentions) Aβ1 40, by Thermo Fisher Scientific (1 mentions) Ptau ser396, by Thermo Fisher Scientific (1 mentions) Tnf α, by Abcam (1 mentions) Tdp 43, by Proteintech (1 mentions) Interleukin 6 (il 6), by Abcam (1 mentions)

2 protocols using neurofilament light

Biomarker Validation in Rhesus Monkeys

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Validation of human ELISAs using rhesus monkey samples were validated in our previous study⁷. Aβ1‐42, Aβ1‐40, t‐tau, p‐tau Ser199, p‐tau Thr231, p‐tau Ser396 (Invitrogen), TNF‐α, IL‐6, TREM2, BDNF (Abcam), TDP‐43 (Proteintech), and neurofilament‐light (Uman Diagnostics) ELISA assays were performed according to each kit manufacturer's instructions, after sample dilution optimization.

Beckman D., Chakrabarty P., Ott S., Dao A., Zhou E., Janssen W.G., Donis‐Cox K., Muller S., Kordower J.H, & Morrison J.H. (2021). A novel tau‐based rhesus monkey model of Alzheimer's pathogenesis. Alzheimer's & Dementia, 17(6), 933-945.

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Biomarker Analysis in Serum and CSF

Cited 1 time

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Serum and CSF were collected as previously described [12 (link)]. In brief, blood and CSF samples were collected in the morning, with separation and freezing of serum and cell-free CSF at −80 °C within 1 h. Routine blood and CSF analyses (in the Departments of Clinical Chemistry and Clinical Immunology, Karolinska Institute) included cell counts, protein concentrations, immune electrophoresis (for the presence of oligoclonal bands) and neurofilament-light concentrations (Uman Diagnostics, Umeå, Sweden).

Theorell J., Ramberger M., Harrison R., Mgbachi V., Jacobson L., Waters P., Erhardt S., Sellgren C.M., Cervenka S., Piehl F, & Irani S.R. (2021). Screening for pathogenic neuronal autoantibodies in serum and CSF of patients with first-episode psychosis. Translational Psychiatry, 11, 566.

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