Amx400

Column chromatography was performed on silica gel (Silica-P flash silica gel from Silicycle, size 40–63 μm). TLC was performed on silica gel 60/Kieselguhr F254. Mass spectra were recorded on an AEI-MS-902 mass spectrometer (EI+) or a LTQ Orbitrap XL (ESI+). ¹H, ¹³C, and ¹⁹F NMR were recorded on a Varian AMX400 (400, 100.6, and 376 MHz, respectively) or a Varian Unity Plus Varian-500 (500, 125, and 471 MHz, respectively). Chemical shift values for ¹H and ¹³C NMR are reported in ppm with the solvent resonance as the internal standard (CHCl₃: δ 7.26 ppm for ¹H, δ77.0 ppm for ¹³C). Data are reported as follows: chemical shifts, multiplicity (s = singlet, d = doublet, t = triplet, q = quartet, br = broad, m = multiplet), coupling constants (Hz), and integration. Melting points were determined on a Buchi B–545 melting point apparatus. All reactions were performed under anhydrous conditions and under N₂ atmosphere. All chemicals used were of analytical grade and were used as received without any further purification. All anhydrous solvents used in reactions were purchased in SureSeal bottles or dried over molecular sieves. Flash column chromatography was performed on Biotage Isolelera One with prepacked columns.