1 2 distearoyl sn glycero 3 phosphoethanolamine n methoxy polyethylene glycol 550 ammonium salt dspe mpeg550

Carboxylatedpoly(vinyl chloride) (>97% GC) (PVCCOOH), bis-(2-ethylhexyl)sebacate (DOS), polycaprolactone (M_n 70,000-90,000) (PCL), tridodecylmethylammonium chloride (TDMAC), alizarin, 4-carboxy-3-fluorophenylboronic acid (1), 3-fluoro-4-methoxycarbonylphenylboronic acid (2a), D-(+)-glucose, tetrahydrofuran (≥ 99.9%) (THF), dicyclohexylcarbodiimide solution (60% w/v in xylene) (DCC), N-hydroxysuccinimide (NHS), aniline(≥ 99.5%), 1-propanol (anhydrous, 99.7%), 1-butanol (HPLC, 99.7%), 1-hexanol (98%), cyclohexanol(99%),sodium sulfate (anhydrous,≥ 99.9%), sodium chloride, ethyl acetate (anhydrous, 99.8%), hexane (anhydrous, 99.5%), N, N’-dimethylformamide (DMF) and N, N’-dimethylaminopyridine (DMAP) were purchased from Sigma Aldrich (St Louis, MO, USA). Octylboronic acid (>97%) and Citroflex A-6 were acquired from Synthonix (Wake Forest, NC, USA) and Vertellus (Indianapolis, IN, USA), respectively. Phosphate Buffered Saline (PBS) (1x, pH = 7.4) was purchased as a solution from Invitrogen (Carlsbad, CA, USA). Hydrochloric acid (1.0 N) and sodium bicarbonate were purchased from Fisher Scientific (Fair Lawn, NJ, USA). 1,2-distearoyl-snglycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-550] (ammonium salt) (DSPE-mPEG550) was purchased from Avanti Polar Lipids, Inc. SKH1-E mice were acquired from Charles River Laboratories International Inc. (Wilmington, MA).

Bis(2-ethylhexyl) sebacate (DOS), chromoionophore II (CHII, 9-Dimethylamino-5-[4-(16-butyl-2,14-dioxo-3,15-dioxaeicosyl)phenylimino]benzo[a]phenoxazine, ETH 2439), potassium ionophore III (KI3, 2-Dodecyl-2-methyl-1,3-propanediyl bis[N-[5′-nitro(benzo-15-crown-5)-4′-yl]carbamate]), Sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (NaBARF), 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES), sodium chloride (NaCl), dichloromethane (DCM) and tetrahydrofuran (THF) were purchased from Sigma-Aldrich. Quantum dots were purchased from NN-Labs (emission peak 640 nm, CZ640) and Cytodiagnostics (emission peak 490 nm, FN-490). Tris Base was purchased from Fisher BioReagents. Spectra/Por in vivo micro-dialysis hollow fibers (inner diameter 200 μm; outer diameter 280 μm, MWCO 13 kD) were purchased from Spectrum Labs, Inc. 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-550] (ammonium salt) (DSPE-mPEG550) was purchased from Avanti Polar Lipids, Inc.