Riluzole hydrochloride

Manufactured by Bio-Techne

Sourced in United Kingdom

Riluzole hydrochloride is a chemical compound used in laboratory research. It is the hydrochloride salt of riluzole, which is a medication used to treat amyotrophic lateral sclerosis (ALS). Riluzole hydrochloride is typically used for in vitro studies and drug development research.

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Lab products found in correlation

Bay36 7620, by Bio-Techne (1 mentions) Alexa fluor 488 conjugate, by Cell Signaling Technology (1 mentions) Norepinephrine, by Merck Group (1 mentions) Carbachol, by Merck Group (1 mentions) Artemisinin, by Merck Group (1 mentions) Trpc6 pam c20, by Bio-Techne (1 mentions) Gsk1702934a, by Bio-Techne (1 mentions) 1 oleoyl 2 acetyl sn glycerol, by Merck Group (1 mentions) Englerin a, by Carl Roth (1 mentions)

Close spelling variants of this product

Riluzole (12 citations)

2 protocols using riluzole hydrochloride

Molecular Mechanisms of GRM1 Regulation

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Riluzole hydrochloride (Tocris Bioscience, Bristol, UK) and BAY 36-7620 (Tocris Bioscience, Bristol, UK) were dissolved in DMSO. GRM1 primary antibody is specific to the C-terminal region of human GRM1α and was used at a dilution of 1:2000 for Western blotting (catalog number 36350002; Novus Biologicals, Littleton, CO). Additional primary antibodies for Western blotting or immunofluorescence include monoclonal anti-ß-actin clone AC-15 (Sigma Aldrich, St. Louis, MO); phospho-cdc2 (Tyr15), cyclin B1, phospho-histone H2AX (Ser139) (Cell Signaling, Danvers, MA). Primary antibodies for flow cytometry include phospho-histone H3 (Ser10) rabbit monoclonal (Alexa Fluor^® 488 conjugate), histone H3 rabbit monoclonal (Alexa Fluor^® 647 conjugate), rabbit monoclonal IgG isotype control (Alexa Fluor^® 488 conjugate), rabbit monoclonal IgG isotype control (Alexa Fluor^® 647 conjugate) (Cell Signaling, Danvers, MA).

Dolfi S.C., Medina D.J., Kareddula A., Paratala B., Rose A., Dhami J., Chen S., Ganesan S., Mackay G., Vazquez A, & Hirshfield K.M. (2017). Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. Oncotarget, 8(27), 44639-44653.

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Pharmacological Compounds for Research

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Artemisinin, carbachol, norepinephrine, and 1-oleoyl-2-acetyl-sn-glycerol (OAG) were purchased from Sigma-Aldrich. GSK 1702934A, TRPC6-PAM-C20 and riluzole hydrochloride were purchased from Tocris (Bristol, UK), and (−)-englerin A was purchased from Carl Roth (Karlsruhe, Germany).

Hermann C., Treder A., Näher M., Geiseler R., Gudermann T., Mederos y Schnitzler M, & Storch U. (2022). The normalized slope conductance as a tool for quantitative analysis of current-voltage relations. Biophysical Journal, 121(8), 1435-1448.

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