Biograph mct 64 pet ct

All patients in the cohort underwent whole body ¹⁸F-FDG PET/CT (Biograph mCT-64 PET/CT, Siemens Medical Solution) scans according to European Association of Nuclear Medicine guidelines for children tumor imaging at baseline (before starting chemotherapy) (17 (link)). Patients were instructed to fast for at least 6 hours, to make the blood glucose level under 11.1 mmol/L before the ¹⁸F-FDG injection. A mean dose of about 3.7 MBq/kg (0.10 mCi/kg) was administrated, considering the patients were children. If needed, infants were sedated using chloral hydrate 40 minutes after the ¹⁸F-FDG injection. About an hour after the injection, a low-dose CT scan (tube voltage 120 keV, thickness 3 mm) was performed for viewing anatomic structures and attenuation correction. A PET scan was performed immediately after CT acquisition in a three-dimensional (3D) mode (2 min/bed position). PET images were reconstructed with the time-of-flight ordered subsets-expectation maximization algorithm.

All patients underwent whole body (from vertex to toes) scan on the PET/CT scanner (Biograph mCT-64 PET/CT; Siemens, Erlangen, Germany) in accordance with European Association of Nuclear Medicine guidelines (17 (link)). Before the injection, they were told to stop any vigorous exercise for at least 24 hours and fast for at least 6 hours. A quantity of 0.14 mCi/kg of ¹⁸F-FDG (provided by Beijing Atomic High-tech Co., Ltd., Beijing, China) was injected intravenously 40–60 minutes before the PET/CT scan. First, a low-dose CT scan could use an automated modulated tube current and 120 kV tube voltage was carried out for anatomical reference and attenuation correction. The CT image parameters were as follows: pixel size 0.586×0.586 mm, 2 mm slice thickness, and matrix size 512×512. The whole-body CT scan was followed immediately by a 2-minute PET scan for each bed position. PET images were reconstructed using time-of-flight (ToF) and the ordered subsets-expectation maximization (OSEM) technique. Attenuation corrections were applied during the reconstruction and a 5 mm Gaussian filter was applied to the PET images. The PET image parameters were as follows: pixel size 4.07×4.07 mm, 3 mm slice thickness, and matrix size 200×200.

¹⁸F-FDG is produced by Japan’s Sumitomo Cyclotron HM-10HC, which ensures each drug batch meets the requirements through strict quality control. The imaging equipment is a Siemens Biograph mCT-64 PET/CT. Before the examination, the patient fasted for more than 6 h, monitored the fasting blood glucose level, and was injected with ¹⁸F-FDG intravenously in a quiet state. The injection dose was 0.10–0.15mCi/kg and the patient was instructed to drink more water and urinate. After the imaging agent was injected, the patient rested quietly for 40–60 min. Before the examination, he emptied the bladder and drank 300–500 ml of water to fill the stomach. It is recommended to choose the correct scanning protocol for image acquisition to perform a full-body CT scan (voltage 120 kV, current through 3D automatic real-time control by milliampere technology and CT scan with a thickness of 5 mm), and then collect whole-body PET, with the scan range from the top of the head to the upper femur. The PET scan has 6–7 beds, each bed is collected for 1.5 min, and the entire scanning process takes about 15 min. Attenuation correction is performed on the collected data. The PET/CT whole-body imaging adopts the ordered subset maximum expected value method (OS-EM) for image reconstruction and transmits it to the Syngo MI workstation for image fusion.

All patients underwent PET/CT whole-body scans (Biograph mCT-64 PET/CT; Siemens) according to the European Association of Nuclear Medicine (EANM) guidelines (15 (link),16 (link)). Prior to the scan, they were asked to fast for at least 6 h and to reduce high-intensity exercise for at least 24 h. ¹⁸F-FDG 0.10–0.15 MBq/kg (provided by Beijing Atomic Technology Co., Ltd.) was injected intravenously 40–60 min before the PET/CT scan. A low-dose CT scan with anatomical reference and attenuation correction was first performed with a tube voltage of 120 kV and automatic tube current modulation. The CT imaging parameters were as follows: resolution 0.586 mm × 0.586 mm, slice thickness 2 mm, and matrix size 512×512. The whole-body CT scan was immediately followed by a PET scan for 2 min in each bed. The ordered subset expectation maximization (OSEM) algorithm with time of flight (TOF) was used to reconstruct the PET images. The PET imaging parameters were as follows: resolution 4.07 mm × 4.07 mm, slice thickness 3 mm, and matrix size 200×200.