Deferoxamine mesylate

Manufactured by Selleck Chemicals

Sourced in United States

Deferoxamine mesylate is a pharmaceutical compound used as a chelating agent. It binds to iron and other metal ions, facilitating their removal from the body. The compound is commonly used in the treatment of iron overload conditions.

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Lab products found in correlation

Z vad fmk, by Selleck Chemicals (3 mentions) Erastin, by Selleck Chemicals (3 mentions) Ferrostatin 1, by Selleck Chemicals (2 mentions) Liproxstatin 1, by Selleck Chemicals (2 mentions) Necrosulfonamide, by Selleck Chemicals (1 mentions) Cc 3118, by Lonza (1 mentions) 3 ma hy 19312, by MedChemExpress (1 mentions) Z vad fmk s7023, by Selleck Chemicals (1 mentions) Anti bcl 2, by Cell Signaling Technology (1 mentions) Anti e cadherin, by Cell Signaling Technology (1 mentions) Anti phospho iκbα, by Cell Signaling Technology (1 mentions) Dimethyl sulfoxide (dmso), by Wuhan Servicebio Technology (1 mentions) Anti bad, by Cell Signaling Technology (1 mentions) Erastin hy 15763, by MedChemExpress (1 mentions) Anti p65 sc 8008, by Santa Cruz Biotechnology (1 mentions) Anti cyclin d1 60186 1 ig, by Proteintech (1 mentions) Anti zeb 1 21544 1 ap, by Proteintech (1 mentions) Anti nrf2 m200 3, by Medical & Biological Laboratories (1 mentions) Anti gpx4 67763 1 ig, by Proteintech (1 mentions) Anti gapdh 60004 1 ig, by Proteintech (1 mentions)

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Deferoxamine (9 citations)

6 protocols using deferoxamine mesylate

Culturing A549 and Small Airway Cells

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A549 cells (American Type Culture Collection, #CCL-185) were cultured in DMEM supplemented with 10% heat-inactivated fetal bovine serum (FBS). The cells were passaged <20 times. Small airway epithelial cells (American Type Culture Collection, #PCS-301-010) were cultured in small airway epithelial growth media (Lonza #CC-3118) and passaged < 7 times. For studies using cell death inhibitors, deferoxamine mesylate (Selleckchem #S5742), necrosulfonamide (Selleckchem #S8251), and Z-VAD-FMK (Selleckchem #S7023) were dissolved in DMSO, and cells were treated at indicated concentrations

Sauler M., McDonough J.E., Adams T.S., Kothapalli N., Barnthaler T., Werder R.B., Schupp J.C., Nouws J., Robertson M.J., Coarfa C., Yang T., Chioccioli M., Omote N., Cosme C J.r., Poli S., Ayaub E.A., Chu S.G., Jensen K.H., Gomez J.L., Britto C.J., Raredon M.S., Niklason L.E., Wilson A.A., Timshel P.N., Kaminski N, & Rosas I.O. (2022). Characterization of the COPD alveolar niche using single-cell RNA sequencing. Nature Communications, 13, 494.

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Ferroptosis Regulation by Molecular Inhibitors

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Myrislignan (S3261), Z-VAD-FMK (S7023), necrosulfonamide (S8251), ferrostatin-1 (S7243), deferoxamine mesylate (S5742), and RSL3 (S8155) were purchased from Selleck (USA). 3-MA (HY-19312) and erastin (HY-15763) were purchased from MedChemExpress (USA). Dimethyl sulfoxide (DMSO) was obtained from Servicebio (G5051, China). The following antibodies were used: anti-GAPDH (60004-1-Ig, Proteintech), anti-E-cadherin (14472, Cell Signaling Technology), anti-Snail-1 (13099-1-AP, Proteintech), anti-Slug (GTX128796, GeneTex), anti-p65 (sc-8008, Santa Cruz), anti-p-p65 (sc-136548, Santa Cruz), anti-phospho-IκB-α (2859, Cell Signaling Technology), anti-IκB-α (CSB-RA015761A0HU, Cusabio Technology), anti-SLC7A11 (NB300-318, Novus), anti-β-catenin (phospho Y142, ab27798, Abcam), anti-β-catenin (ab32572, Abcam), anti-Cyclin-D1 (60186-1-Ig, Proteintech), anti-Bad (9292, Cell Signaling Technology), anti-Bcl2 (15017, Cell Signaling Technology), anti-Vimentin (GB111308, Servicebio), anti-Twist (25465-1-AP, Proteintech), anti-ZEB1 (21544-1-AP, Proteintech), anti-Nrf2 (M200-3, Medical and Biological Laboratories), anti-TFR1 (ab214039, Abcam), and anti-GPX4 (67763-1-Ig, Proteintech).

Zhou Y., Qian W., Li X, & Wei W. (2023). NF-κB Inhibitor Myrislignan Induces Ferroptosis of Glioblastoma Cells via Regulating Epithelial-Mesenchymal Transformation in a Slug-Dependent Manner. Oxidative Medicine and Cellular Longevity, 2023, 7098313.

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Comprehensive Toolkit for Cancer Research

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RSL3 (S8155), neratinib (S2150), lapatinib (S2111), gefitinib (S1025), ML210 (S0788), afatinib (S1011), dacomitinib (S2727), sapitinib (S2192), Z-VAD-FMK (S7023), necrostatin-1 (S8037), 3-Methyladenine (3-MA, S2767), tucatinib (S8362), liproxstatin-1 (S7699), erastin (S7242), deferoxamine mesylate (DFO, S5742), deferiprone (S4067), ferrostatin-1 (S7243), cobimetinib (S8041), Trastuzumab (A2007) and AZD6738 (S7693) were obtained from Selleck Chemicals. L-glutathione (G6013) and N-Acetyl-l-cysteine (A9165) were purchased from Sigma-Aldrich. T-DM1 (HY-P9921) was obtained from MedChemExpress.

Park S.Y., Jeong K.J., Poire A., Zhang D., Tsang Y.H., Blucher A.S, & Mills G.B. (2023). Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer. Cell Death & Disease, 14(8), 532.

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Cell Culture of GIST Cancer Lines

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The human GIST882 cell line [31 (link)] was kindly provided by Dr. Jonathan A. Fletcher, Harvard Medical School, Boston, MA, USA. Cells were cultured at 37 °C in DMEM (Gibco, CA, USA, Cat# 41965-062), supplemented with 10% (v/v) FBS, 2% (v/v) penicillin–streptomycin (Gibco, CA, USA, Cat# 15140-122). The human GIST48 cell line [32 (link)] was kindly provided by Dr. Ronald DeMatteo, Perelman School of Medicine, Philadelphia, PA, USA. Cells were cultured at 37 °C in RPMI-1640 (Gibco, CA, USA, Cat# 31870-074), supplemented with 10% (v/v) FBS, 1% (v/v) L-glutamine (Gibco, CA, USA, Cat# 35050-038), 1% (v/v) HEPES (Gibco, CA, USA, Cat# 15630-056), 0.1% (v/v) 2-mercaptoethanol (Gibco, CA, USA, Cat# 31350-010), and 0.5% (v/v) penicillin–streptomycin. Verteporfin and cumene hydroperoxide were purchased from Sigma, St. Louis, MO, USA (Cat# C0737, SML0534, and 247502, respectively). Erastin, liproxstatin-1, deferoxamine mesylate, RSL3, CA3, and staurosporine were purchased from Selleckchem, Houston, TX, USA (Cat# S7242, S7699, S5742, S8155, S8661, and S1421, respectively).

Delvaux M., Hagué P., Craciun L., Wozniak A., Demetter P., Schöffski P., Erneux C, & Vanderwinden J.M. (2022). Ferroptosis Induction and YAP Inhibition as New Therapeutic Targets in Gastrointestinal Stromal Tumors (GISTs). Cancers, 14(20), 5050.

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Cardiomyocyte Isolation and Inhibitor Pretreatment

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We isolated primary cardiomyocytes from Sprague‒Dawley rat heart tissue using previously described procedures [22 (link)]. H9c2 cardiomyocytes were acquired from the National Collection of Authenticated Cell Cultures (Shanghai, China). All cells were cultured with DMEM containing glucose (Gibco, USA, 4.5 g/L), and 10 % fetal bovine serum (Gibco, USA) and 1 % penicillin and streptomycin solution were added at 37 °C in a 5 % CO₂ incubator. Cardiomyocytes were pretreated with A-438079 (an inhibitor of P2X7R) from Selleck (#S7705, 10 μM), deferoxamine mesylate from Selleck (#S5742, 50 or 100 μM), or ferrostatin-1 from Selleck (#S7243, 1 or 5 μM) for 2 h before stimulation with Ang II (1 μM).

Zhong X., Wang K., Wang Y., Wang L., Wang S., Huang W., Jia Z., Dai S.S, & Huang Z. (2024). Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R. Redox Biology, 72, 103154.

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Pharmacological Compounds for Cell Death Pathways

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Doxorubicin (#T1020) was purchased from TargetMol (Wellesley Hills, MA, USA). 17-PT-PGE₂ (#14810) and SC-51322 (#10010744) were obtained from Cayman Chemical Company (Ann Arbor, MI, USA). U73122 (#U6756), and staurosporine (#539648) was obtained from Sigma Company (Sigma-Aldrich, St. Louis, MO, USA). Erastin (#S7242), RSL3 (#S8155), Fer-1 (#S7243), Nec-1s (#S8641), Bafilomycin A1 (#S1413), Z-VAD-FMK (#S7023), Trolox (#S3665), Deferoxamine mesylate (#S5742) and ML-385 (#S8790) were purchased from Selleck Chemicals (Houston, TX, USA). Wortmannin (#HY-10197), SP600125 (#HY-12041), and Ravoxertinib (#HY-15947) were purchased from MedChemExpress (MCE) Company (Shanghai, China).

Wang B., Jin Y., Liu J., Liu Q., Shen Y., Zuo S, & Yu Y. (2023). EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2. Redox Biology, 65, 102825.

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