Thalidomide was purchased from Olon S.p.A. (Milan, Italy). Phenacetin was obtained from Carlo Erba (Milan, Italy). β-cyclodextrin and hydroxypropyl-β-cyclodextrin were supplied by Roquette (Lestrem, France). Sulphobutylether-β-cyclodextrin was kindly donated by CYDEX Pharmaceuticals (Lawrence, KS, USA). Lecithin (LIPOID S45) was supplied by Lipoid AG (Steinhausen, Switzerland). HPLC-grade acetonitrile was obtained from VWR International S.r.l. (Milan, Italy). All other reagents and solvents used were analytical grade.
Lecithin s45
Manufactured by Lipoid
Sourced in Switzerland, Germany
Lecithin (LIPOID S45) is a natural phospholipid derived from soy. It is an emulsifier and wetting agent commonly used in various industries.
Automatically generated - may contain errors
Lab products found in correlation
Hplc grade acetonitrile, by Avantor (1 mentions)
β cyclodextrin, by Roquette (1 mentions)
Hydroxypropyl β cyclodextrin, by Roquette (1 mentions)
Hplc grade acetonitrile, by Merck Group (1 mentions)
Isopropyl alcohol, by Merck Group (1 mentions)
Mannitol, by Merck Group (1 mentions)
λ carrageenan, by Merck Group (1 mentions)
Polyethylene glycol 400 peg 400, by Merck Group (1 mentions)
Dermovate, by GlaxoSmithKline (1 mentions)
Clobetasol 17 propionate, by GlaxoSmithKline (1 mentions)
4 protocols using lecithin s45
1
Cyclodextrin-based drug formulations
2
Flurbiprofen API Analytical Standards
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Flurbiprofen raw material or API (batch n° T17121044) was kindly donated by Recordati S.p.A. (I-Milano). This drug substance was used for the preparation of the HPLC analytical standards and also as reference powder in the in vitro and ex vivo transport experiments. Mannitol (Ph. Eur.) was supplied by Lisapharma S.p.A. (I-Erba) and lecithin (Lipoid ® S45) by Lipoid AG (CH-Steinhausen). HPLC-grade acetonitrile and isopropyl alcohol were supplied by Sigma-Aldrich ® (St. Louis, MO, USA). All other reagents and solvents were analytical grade.
3
Clobetasol-17-propionate Nanoparticle Formulation
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Clobetasol-17-propionate (CP) was a kind gift from GlaxoSmithKline (Ankara, Turkey). Lecithin (Lipoid S45) was purchased from Lipoid AG (Ludwigshafen, Germany) and chitosan (Chitoclear FG, specifications: deacetylation degree 95%, viscosity 93 cP for 1% w/v solution in 1% v/v acetic acid) for nanoparticles preparation was from Primex (Haugesund, Norway). Medium molecular weight chitosan (specifications: MW 190-310 kDa, deacetylation degree 75%–85%, viscosity 200–800 cP for 1% w/v solution in 1% v/v acetic acid) for gel preparation as well as λ carrageenan used for hind paw test was obtained from Sigma-Aldrich (St. Louis, MO, USA). Polyethylene glycol 400 (PEG 400) and mannitol were provided from Merck (Darmstadt, Germany). Sodium deoxycholate (Na-DOC) was purchased from Fluka (Munich, Germany). All other chemicals were of analytical grade.
A commercial drug product in form of cream containing 0.05% of Clobetasol-17-propionate, Dermovate® (GSK, Uxbridge, UK) was used as reference formulation.
A commercial drug product in form of cream containing 0.05% of Clobetasol-17-propionate, Dermovate® (GSK, Uxbridge, UK) was used as reference formulation.
4
Ribavirin Polymorph Characterization Protocol
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Ribavirin raw material (batch #001-RIB-0908) was kindly donated by Euticals S.p.A. (Lodi, MI, Italy). The micronized powder was demonstrated to be exclusively the crystalline polymorph R-I by X-ray diffraction (data not shown) and DSC (Tm =180 °C), probably as a result of the milling process as reported by Vasa (Vasa & Wildfong, 2017 (link)). RBV analytical standard was purchased from Sigma Chemical Company (St. Louis, MO). The internal standard (IS) 13C5RBV was obtained from Campro Scientific GmbH (Berlin, Germany). Mannitol was a kind gift of Lisapharma S.p.A. (Erba, Italy). Chitosan (ChitoClear®, batch TM1874) was supplied by Primex (Siglufjordur, Iceland). The oligosaccharide α-cyclodextrin (α–CD, A.C.E.F. S.p.A., Fiorenzuola d’Arda, Italy). Lecithin (LIPOID S45) was obtained from Lipoid GmBH (Ludwigshafen, Germany). Degassed ultrapure water (Purelab Flex, ELGA-Veolia LabWater, Zoppola, Italy) was used in all experiments. All other reagents and solvents were of analytical grade.
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