3t mr system

Manufactured by Siemens

Sourced in Germany

The 3T MR system is a magnetic resonance imaging (MRI) device that operates at a magnetic field strength of 3 Tesla. It is designed to produce high-quality, detailed images of the body's internal structures. The 3T MR system utilizes advanced imaging technology to capture detailed images without the use of ionizing radiation.

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6 protocols using 3t mr system

Quantifying Basal Ganglia Glutamate Levels

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In vivo levels of glutamate as reflected by the glutamate (Glu) to creatine (Cr) ratio (Glu/Cr) were obtained by ¹H MRS from 2 voxels each of 17 × 30 ×17 mm³ located on the right and left basal ganglia and one voxel sized 20 × 30 × 10 mm³ located on the dACC (BA24). Imaging was performed on a Siemens 3T MR system as described (Haroon et al 2014 (link)). In brief, a standard point-resolved spectroscopy sequence (PRESS) was used for spatial localization, and chemical shift selective (CHESS) pulses were used for water suppression. The parameters used for spectral acquisition were TR=3000msec, TE=30msec, sampling size=1024, 128 averages. Post processing was accomplished using LC Model software. Only Glu/Cr values whose metabolite variance ratios (Cramer-Rao lower bounds-CRLB) were <20% were used for analysis. MRS data from 2 left basal ganglia and 1 dACC voxels from older IFN-alpha treated individuals were excluded due to CRLB>20%. Water was used as the internal reference, and creatine (Cr) was used to scale the data to model spectra across subjects (per LC Model Manual) and to minimize intra- and inter-individual variation (Provencher, 2012 ). No significant between group difference in Cr concentrations was seen in any voxels, nor were there any differences in Cr concentrations between Visit 1 and Visit 2 for either group.

Haroon E., Felger J.C., Woolwine B.J., Chen X., Parekh S., Spivey J., Hu X, & Miller A.H. (2014). Age-Related Increases in Basal Ganglia Glutamate are Associated with TNF-Alpha, Reduced Motivation and Decreased Psychomotor Speed During IFN-alpha Treatment: Preliminary Findings. Brain, behavior, and immunity, 46, 17-22.

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Structural and Functional Neuroimaging in 3T MRI

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Subjects were scanned in a 3T MR system (Prisma Siemens, Erlangen, Germany, EU) with a 64 channel head/neck coil. Structural T1-weighted images were acquired for anatomical reference during the first session of the Neutral condition with a 3D rapid gradient-echo sequence (MP-RAGE; TR = 2000 ms; TE = 2.24 ms, flip angle 8°, 192 sagittal slices, FOV = 230 mm, voxel size = 0.9 × 0.9 × 0.9 mm, matrix 256 × 256). Changes in blood oxygen level dependent (BOLD) T2* weighted MR signal were measured, using an interleaved gradient echo-planar imaging (EPI) sequence (TR = 2200 ms, TE = 30 ms, voxel size = 3.0 × 3.0 × 3.0 mm, flip angle 90°, slices/volume 40). A total of 220 EPI volumes were acquired in each functional session. The Statistical Parametric Mapping software (SPM12, Welcome Trust Centre for Neuroimaging, UK) was used for image processing and analyses. The first two scans of each session were removed, then images were slice-time corrected, spatially realigned, co-registered with the MNI152 brain using nonlinear warping, segmented using masks derived from the anatomical scan, and smoothed with a 6-mm FWHM Gaussian kernel. A high-pass temporal filter with a cutoff of 128 s was then applied.

Fauchon C., Faillenot I., Quesada C., Meunier D., Chouchou F., Garcia-Larrea L, & Peyron R. (2019). Brain activity sustaining the modulation of pain by empathetic comments. Scientific Reports, 9, 8398.

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High-Resolution fMRI of Entorhinal Cortex

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MRI data were acquired using a 3T MR system (Siemens). A 32-channel head coil was used. Before the fMRI session, a whole head MP-RAGE volume (TE = 2.28 ms, TR = 2400 ms, TI = 1060 ms, resolution = 0.8 × 0.8 × 0.8 mm isometric) was acquired. This was followed by four fMRI runs, each with 300 volumes, which consisted of 42 T2*-weighted slices with a resolution of 1.7 × 1.7 mm (TE = 30 ms, TR = 1000 ms, slice thickness 1.7 mm, FOV 200 mm, parallel imaging with grappa factor 2). T2*-weighted data were collected at this ultra-high resolution so as to optimize differentiation of BOLD signal in anterolateral versus posterior medial entorhinal cortex. The T2* slices were acquired in odd-even interleaved fashion in the anterior to posterior direction. Subsequently, a T2-weighted image (TE = 564 ms, TR = 3200 ms, resolution 0.8 × 0.8 × 0.8 mm isometric) was acquired. Finally, participants then completed four more fMRI runs. Total duration of MRI acquisition was approximately 60 min.

Ferko K.M., Blumenthal A., Martin C.B., Proklova D., Minos A.N., Saksida L.M., Bussey T.J., Khan A.R, & Köhler S. (2022). Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision. eLife, 11, e66884.

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High-Resolution Structural Brain Imaging

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High-resolution T1-weighted images covering the whole brain were acquired on a 3 T MR system (Siemens Medical System, Erlangen, Germany) using a sagittal 3-dimensional magnetization-prepared rapid gradient echo sequence. Foam padding was used to minimize head motion. The scanning parameters were: repetition time 1900 ms; echo time 2.3 ms; inversion time 900 ms; slice thickness 1 mm; no inter-slice gap; 176 slices; matrix size 256 × 256; field of view 24 × 24 cm²; flip angle 9°. Conventional MRI protocols were performed with a fast spin-echo sequence for the structural assessment: axial T2-weighted and fluid-attenuated inversion recovery images were obtained. Sequence parameters of conventional MRI protocols are described in supplementary materials. Two neuro-radiologists verified image quality and evaluated for clinical abnormalities.

Suo X., Lei D., Li N., Li W., Kemp G.J., Sweeney J.A., Peng R, & Gong Q. (2021). Disrupted morphological grey matter networks in early-stage Parkinson’s disease. Brain Structure & Function, 226(5), 1389-1403.

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Neck Posture MRI Evaluation

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Eleven european healthy subjects (5 females and 6 males, mean age : 30 +/-6y, BMI : 23.86 +/-1.78 31 kg/m²) were scanned using a 3T MR system (Siemens Healthineers, Erlangen, France) equipped with head, 32 neck and spine coils. Subjects were first examined with the neck in neutral and flexion positions, using a

Sudres P., Evin M., Arnoux P.J, & Callot V. (2020). Cervical Canal Morphology: Effects of Neck Flexion in Normal Condition: New Elements for Biomechanical Simulations and Surgical Management. Spine, 45(16).

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MRS Imaging of Metabolic Abnormalities in White Matter Injury

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MRS scans were obtained at a mean GA of 42.5 ± 1.6 weeks using a Siemens 3T MR system. Single-voxel 1H-MR spectra using point-resolved spectroscopy (PRESS) were acquired with a relaxation time of 1.5 s, and signal averages of 128. A single voxel size of 15 x 15 x 15 mm was used for measurements in the basal ganglia (BG) and in the frontal lobe white matter (WM) (Figure 2). Spectra were fit using LCModel with standard Siemens basis sets, with standard deviation (SD) < 20% as the standard for inclusion of metabolites. The concentration of metabolites NAA, total choline (Cho) and total creatine (Cr) were measured at both short (30 ms) and long (270 ms) echo times (TE), while myo-inositol (mI), glutamate (Glu) and glutamate + glutamine (Glx) were only measured at short TE, due to poor resolution at longer echo times. These metabolites have been shown to be abnormal in white matter injury [17 (link)]. Ratios of metabolite concentrations obtained at the same echo times were used for analysis (mI/NAA, mI/Cho, mI/Cr, NAA/Cho, NAA/Cr, Glu/Cr, Glx/Cr). The observed percent of SDs of the lactate signals were too high for inclusion in our analyses.

Bentzley J.P., Coker-Bolt P., Moreau N., Hope K., Ramakrishnan V., Brown T., Mulvihill D, & Jenkins D. (2015). Kinematic Measurement of 12-week Head Control Correlates with 12-month Neurodevelopment in Preterm Infants. Early human development, 91(2), 159-164.

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