Acl top 750 cts

Manufactured by Werfen

Sourced in United States

The ACL Top 750 CTS is a high-throughput coagulation analyzer designed for clinical laboratories. It is capable of performing a range of coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen assays. The instrument utilizes clot detection technology to provide accurate and reliable results.

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Lab products found in correlation

Hemosil, by Werfen (1 mentions) Access 2, by Beckman Coulter (1 mentions) Xn 10, by Sysmex (1 mentions) Cobas 8000 c702 analyzer, by Roche (1 mentions) Xn 1000 hematology analyzer, by Sysmex (1 mentions) Cobas e411, by Roche (1 mentions) Hemosil liquid antithrombin, by Werfen (1 mentions)

6 protocols using acl top 750 cts

Genetic Analysis of PROC Gene in Thrombophilia

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In this retrospective study, molecular genetic analysis of the PROC gene was performed in 287 mainly Caucasian patients (215 females and 72 males, mean age 37 [2-83]) with suspected thrombophilia at 2 centers in Germany (Bonn and Dortmund) between January 2015 and August 2019. Most of the individuals (n = 269, 94%) were not related, while for 18 individuals from 7 families, a family examination was carried out.
Analyzed clinical data included information on positive personal or family history of VTE and vascular pregnancy complications (eg, recurrent miscarriages, preeclampsia, etc). Venous blood samples were collected in citrate plasma (Sarstedt, citrate buffer 3.2%). Protein C activity testing was performed on ACL Top 750 CTS (Werfen, Spain) using a clotting time based (Hemoclot; CoaChrom Diagnostica, Vienna, Austria; and HemosIL; Werfen, Barcelona, Spain) and a chromogenic assay (HemosIL), respectively (reference range in both assays 70%-140%). Protein C concentration was determined by an enzyme immunoassay on Euroimmun Analyzer (Zymotest; CoaChrom Diagnostica, reference range 60%-140%) or by immunodiffusion (reference range: 1.62-3.14 mg/L).

Seidel H., Haracska B., Naumann J., Westhofen P., Hass M.S, & Kruppenbacher J.P. (2020). Laboratory Limitations of Excluding Hereditary Protein C Deficiency by Chromogenic Assay: Discrepancies of Phenotype and Genotype. Clinical and Applied Thrombosis/Hemostasis, 26, 1076029620912028.

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Plasma FG Levels in S. aureus Infection

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Acid-citrate-dextrose (ACD)-plasma of patients was collected after a positive bacteriological diagnosis for S. aureus infection by the clinical personnel of the Intensive Care Unit (ICU) in Humanitas Research Hospital under Ethic Statement Approval n° 820/18. One patient with septic shock from osteomyelitis undergoing multiple surgeries complicated by infective endocarditis of the mitral valve (Pz 1) and a patient with bacteremia and sepsis from an epidural abscess (Pz 2) were included for the sample collection. Informed consent was obtained from all subjects involved in the study. The levels of FG in the ACD-plasma vs. serum of normal donors (n = 3) were measured by ACL TOP^® 750 CTS (Werfen, Milan, Italy).

Parente R., Fumagalli M.R., Di Claudio A., Cárdenas Rincón C.L., Erreni M., Zanini D., Iapichino G., Protti A., Garlanda C., Rusconi R, & Doni A. (2023). A Multilayered Imaging and Microfluidics Approach for Evaluating the Effect of Fibrinolysis in Staphylococcus aureus Biofilm Formation. Pathogens, 12(9), 1141.

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Comprehensive Hepatic and Hematological Assessment

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All blood samples were tested in the laboratory of Beijing Ditan Hospital, Capital Medical University, on the day of collection. The liver functions, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB), total bilirubin (TBil), renal function (creatinine), and FBG, were examined using an automatic biochemical analyzer (Hitachi, 7600-020). The blood routine, such as white blood cells (WBC), red blood cells (RBC), blood platelets (PLT), and hemoglobin (HGB), was examined using an automatic blood cell analyzer (Sysmex, XN-10). The prothrombin time was examined using an automatic blood coagulation analyzer (Werfen, ACLTOP750CTS). The serum markers of HBV (hepatitis B surface antigen, hepatitis B surface antibody, hepatitis B e antigen, and so on) were analyzed using an automatic chemiluminescence analyzer (Beckman Coulter, ACCESS2). The HBV DNA load was examined using a gene amplification instrument and its supporting reagent (Roche, Cobas).

Sun X., Chi X., Zhao Y., Liu S, & Xing H. (2022). Characteristics and Clinical Significance of Intestinal Microbiota in Patients with Chronic Hepatitis B Cirrhosis and Type 2 Diabetes Mellitus. Journal of Diabetes Research, 2022, 1826181.

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Comprehensive Blood Analysis Protocol

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Blood cell analysis was performed on XN 1000 hematology analyzer (Sysmex, Kobe, Japan), using whole blood samples in tubes with K3EDTA (Ethylene Diamine Tetra Acetic acid) as anticoagulant. Measurements of urea, creatinine, SGOT, SGPT and CRP were done in serum samples on the DxC 700 AU instrument (BECKMAN COULTER^®, Brea, CA, USA). The suPAR was determined by the suPARnostic^® TurbiLatex assay (Birkerød, Denmark) on the Cobas^® 8000 c702 analyzer (Roche Diagnostics, Mannheim, Germany) using K3-EDTA plasma samples. The measurement of IL-6 was performed on the Cobas^® e 411 (Roche Diagnostics, Mannheim, Germany) in serum samples. D-dimers were measured on the ACL TOP 750 CTS (Instrumentation Laboratory, Bedford, MA, USA) coagulation analyzer in plasma samples retrieved from whole blood, drawn into buffered sodium citrate (0.109 M, 3.2%) tubes after centrifugation at 3000 rpm for 10 min.

Meletis G., Tychala A., Ntritsos G., Verrou E., Savvidou F., Dermitzakis I., Chatzidimitriou A., Gkeka I., Fyntanidou B., Gkarmiri S., Tzallas A.T., Protonotariou E., Makedou K., Tsalikakis D.G, & Skoura L. (2023). Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study. Biomedicines, 11(4), 1143.

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Haemolysis Impact on Routine Coagulation Tests

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Haemolysis influence was studied on the paired results of the five most commonly performed laboratory tests: PT, aPTT, Fib, Dimer-D (DD) and antithrombin (AT). All tests and automatic haemolysis assessment were performed using the same instrument (ACL TOP 750-CTS, Instrumentation Laboratory, Bedford, USA) and using proprietary reagents (Instrumentation Laboratory, Bedford, USA) as follows: PT, HemosIL RecombiPlasTin 2G (reference range: 9.1 - 13.7 sec, ratio 0.80 - 1.20, ISI = 1.00); aPTT, HemosIL SynthASil (reference range: 24.6 - 37.0 sec, ratio 0.80 - 1.20); D-Dimer, HemosIL HS-DD (reference range < 270 ng/mL); Fib, HemosIL QFA Thrombin (reference range: 1.8 - 4.0 g/L) and AT, HemosIL Liquid Antithrombin (reference range: 80 - 120%). The same lot of reagents was used for all analytical sessions. All samples were thawed at 37 °C for 5 min in a water bath immediately before testing.
The tests were completed in 12 different analytical sessions of 20 - 25 paired plasma samples over five consecutive days, using a repetitive H/NH sample sequence. Internal quality controls (HemosiL Normal and Abnormal Control, Instrumentation Laboratory, Bedford, USA), were performed at the beginning of each session and every 2 hours.

Novelli C., Vidali M., Brando B., Morelli B., Andreani G., Arini M., Calzoni P., Giacomello R., Montaruli B., Muccini E., Papa A., Pradella P., Ruocco L., Siviero F., Viola F.G., Zanchetta M., Zardo L, & Lippi G. (2018). A collaborative study by the Working Group on Hemostasis and Thrombosis of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC) on the interference of haemolysis on five routine blood coagulation tests by evaluation of 269 paired haemolysed/non-haemolysed samples. Biochemia Medica, 28(3), 030711.

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Antithrombin III Activity Assay

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The plasma AT‐III activity levels in plasma were determined by chromogenic assay using ACL‐TOP 750 CTS (Instrumentation Laboratory) and factor Xa was used as the enzymatic source. When factor Xa is added to a plasma sample it forms a complex with functionally active AT‐III. Chromogenic substrate (HemosIL Liquid Antithrombin; Instrumentation Laboratory) was added to the mixture and the active AT‐III level was determined by the color change generated by residual factor Xa.

Kim B.R., Lim L., Choi Y., Yi N., Lee K., Suh K., Yu K., Sohn J.Y., Jeong R., Oh J, & Ryu H.G. (2023). Continuous versus intermittent infusion of human antithrombin III concentrate in the immediate postoperative period after liver transplantation. Clinical and Translational Science, 16(7), 1177-1185.

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