Inveon multimodality pet ct

Manufactured by Siemens

Sourced in United States

The Inveon Multimodality PET/CT is a laboratory equipment designed for preclinical imaging. It combines positron emission tomography (PET) and computed tomography (CT) capabilities in a single integrated system.

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Lab products found in correlation

Inveon research workplace software, by Siemens (1 mentions) Inveon research workplace 3, by Siemens (1 mentions) Oftagel, by Santen (1 mentions) Osirix, by Pixmeo (1 mentions)

Close spelling variants of this product

Inveon PET/CT Multimodality System Inveon Multimodality small animal PET/CT scanner Inveon Multimodality PET/CT scanner Inveon PET/CT Inveon Multimodality Inveon PET Inveon

5 protocols using inveon multimodality pet ct

Dynamic PET Imaging of Neuroinflammation

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The mice were anaesthetized with 2–2.5% isoflurane inhalation and kept on a heating pad. They were first imaged with CT for attenuation correction (Inveon Multimodality PET/CT, Siemens Medical Solutions, Knoxville, TN, USA). After CT, approximately 10 MBq of ¹⁸F-GE-180 was administered as an intravenous bolus injection via a tail vein cannula, and a 30-minute dynamic PET was started at the same time with the injection. After PET, 100 µl of intravenous contrast agent (eXIA160XL, Binitio Biomedical Inc., Ottawa, ON, Canada) was injected, and a high-resolution CT was performed as described in [20 (link)]. The PET images were reconstructed with 2D ordered-subset expectation maximization (OSEM2D) algorithm with two iterations into 2 × 30 s, 4 × 60 s, and 5 × 300 s time frames, and CT images were reconstructed with a Feldkamp-based algorithm. The radioactivity concentration in tissues was analysed by defining regions of interest (ROIs) with Carimas 2.9 program (Turku PET Centre, Turku, Finland). The ROI for blood was placed in the left jugular vein. The results were extracted as mean standardized uptake values (SUV) and were plotted as time-activity curves. Mean SUVs at 20–30 min after injection were utilized in numerical calculations.

Hellberg S., Liljenbäck H., Eskola O., Morisson-Iveson V., Morrison M., Trigg W., Saukko P., Ylä-Herttuala S., Knuuti J., Saraste A, & Roivainen A. (2018). Positron Emission Tomography Imaging of Macrophages in Atherosclerosis with 18F-GE-180, a Radiotracer for Translocator Protein (TSPO). Contrast Media & Molecular Imaging, 2018, 9186902.

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In Vivo PET/CT Imaging of Breast Tumors

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One hour before imaging, animals were injected with approximately 150 µCi of ¹⁸F-NaF via tail vein, then scanned at 15 min postcontrast using list-mode PET centered at the tumor site, and a medium magnification CT was performed centering on the breast tumor sites using the Siemens Inveon Multimodality PET/CT. The animals were anesthetized using 2% isoflurane for the duration of the PET/CT scans. PET images were reconstructed using the 3D Ordered Subset Expectation Maximization (3D-OSEM) algorithm into one frame, and CT images were reconstructed using the Feldkamp algorithm and a Shepp-Logan filter. PET and CT images were coregistered using the Inveon Research Workplace (IRW) software (Siemens).

Hajibeigi A., Nasr K., Udayakumar D., Nham K, & Lenkinski R.E. (2018). Breast Tumor Microcalcification Induced by Bone Morphogenetic Protein-2: A New Murine Model for Human Breast Tumor Diagnosis. Contrast Media & Molecular Imaging, 2018, 2082154.

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In-vivo Imaging of Spinal Cord Injury

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The synthesis of [¹⁸F]F-DPA was synthesized as described previously 46 (link). Rats were anesthetized with 1.5-2.5% isoflurane/oxygen on the heating bed for micro PET/CT (Inveon multimodality PET/CT, Siemens Medical Solutions, fuji Knoxville, TN, USA) and a few drops of Oftagel (25 mg/g; Santen, Tampere, Finland) were applied to prevent eye dryness. CT was performed for 10 min as an attenuation and anatomical reference. A 60-min dynamic PET scan (30 × 10 s, 15 × 60 s, 4 × 300 s, and 2 × 600 s) was acquired after intravenous injection with [¹⁸F]F-DPA (22.4 ± 4 MBq). To analyze the uptake of [¹⁸F]F-DPA (Inveon Research Workplace 3.0, Siemens medical Solutions, Knoxville, TN, USA), images were summed over 40-60 min after tracer injection. The uptake of [¹⁸F]F-DPA was quantitatively assessed using SUV_r, which is the ratio between the mean SUV at the injury region (T11-T13) and the mean SUV at a reference region (C2-C4).

Zhang L., Zhuang X., Kotitalo P., Keller T., Krzyczmonik A., Haaparanta-Solin M., Solin O., Forsback S., Grönroos T.J., Han C., López-Picón F.R, & Xia H. (2021). Intravenous transplantation of olfactory ensheathing cells reduces neuroinflammation after spinal cord injury via interleukin-1 receptor antagonist. Theranostics, 11(3), 1147-1161.

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Multimodal Imaging of Murine Kyphosis

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Magnetic resonance imaging (MRI) was performed using a 7 T Bruker ClinScan system (Bruker BioSpin MRI GmbH, Germany) equipped with 12S gradient coil. A two-channel surface coil was used for MR imaging. Animals were anesthetized and maintained with 1.5–2% isoflurane during MRI sessions. Data analysis was done by manually segmenting the regions and computing volumes using OsiriX (v5.7, Pixmeo, Switzerland).
For the kyphosis study, mice were imaged in the prone position for a 3-bed position X-ray Computed Tomography (CT) (Inveon Multi-Modality PET/CT, Siemens Medical Solutions, Knoxville, TN). X-ray CT step and shoot acquisition parameters were: 80 kVp, 500 μA, 1000 msec per step, 180 steps covering 360-degrees. X-ray CT images were reconstructed using a Feldkamp cone beam algorithm with a Shepp-Logan smoothing filter resulting in 512×512×1170 matrix (0.08 × 0.08 × 0.08 μm pixel size). Images were linearly calibrated to Hounsfield units (air: −1000 HU, water: 0 HU). The X-ray CT 3D images (orthogonal axial, coronal, and sagittal views) were displayed using a medical image viewer (MIM v 6.6.5, MIM Software Inc, Cleveland, OH) and a pseudo-3D maximum intensity projection (MIP) was implemented to rotate and translate the mouse into perpendicular orientation for analysis

Callen E., Zong D., Wu W., Wong N., Stanlie A., Ishikawa M., Pavani R., Dumitrache L.C., Byrum A.K., Mendez-Dorantes C., Martinez P., Canela A., Maman Y., Day A., Kruhlak M.J., Blasco M.A., Stark J.M., Mosammaparast N., McKinnon P.J, & Nussenzweig A. (2019). 53BP1 Enforces Distinct Pre- and Post-Resection Blocks on Homologous Recombination. Molecular cell, 77(1), 26-38.e7.

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In Vivo PET/CT Imaging of Brain

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In vivo imaging was performed using an Inveon multimodality PET/CT (Siemens Medical Solutions, USA) small-animal scanner with a 1.2 mm 3 resolution. The device generates images with 159 transaxial slices with a 10-cm transaxial field of view and a 12.7-cm axial field of view. A CT scan was obtained to correct for signal attenuation in the PET scan and provide anatomic references. Emission scans (40 min) were acquired for these studies. The data were acquired in list-mode with an emission window from 350 to 650 MeV. The scans were initiated immediately after the intravenous injection of 18 F-GE180. For the baseline scan, the amount of radioactivity given to animals in the control group was 49.0 6 3.1 MBq (mean 6 SD), and in the fingolimod-treated group it was 46.5 6 6.3 MBq. In the second scan, the amounts were 46.6 6 5.2 and 45.7 6 8.6 MBq, respectively.

Airas L., Dickens A.M., Elo P., Marjamäki P., Johansson J., Eskola O., Jones P.A., Trigg W., Solin O., Haaparanta-Solin M., Anthony D.C, & Rinne J. (2015). In vivo PET imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of multiple sclerosis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(2).

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