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Methanol ulc ms cc sfc grade

Manufactured by Biosolve
Sourced in Netherlands

Methanol (ULC/MS-CC/SFC grade) is a high-purity solvent suitable for use in ultra-low-carry applications, mass spectrometry, capillary chromatography, and supercritical fluid chromatography.

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3 protocols using methanol ulc ms cc sfc grade

1

Quantitative MALDI-MS Sample Preparation

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Methanol (ULC/MS-CC/SFC grade) and chloroform (HPLC grade) were purchased from Biosolve BV (Valkenswaard, The Netherlands). All MALDI matrices, 2, 5-dihydroxybenzoic acid ≥ 98% (DHB), norharmane, N-(1-naphthyl) ethylenediamine dihydrochloride (NEDC), carboxymethyl cellulose (CMC) and amino acid standards were purchased from Sigma Aldrich. Conductive indium tin oxide (ITO)–coated glass slides were purchased from Delta Technologies (Loveland, CO, USA), TAHS (p-N,N,N- trimethylamonioanilyl N-hydroxysuccinimidylcarbamate iodide) was synthesized as described elsewhere (Arts et al. 2017 (link)).
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2

Quantitative Analysis of OSIM and PAZO

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OSIM (free base, purity 95%) and pazopanib (PAZO) (free base, purity 98%) were purchased from Toronto Research Chemicals (Toronto, Ontario, Canada) . Methanol (ULC/MS-CC/SFC grade) was purchased from Biosolve (Valkenswaard, the Netherlands). Acetonitrile (≥99.9%), 2-propanol (≥99.8%) and dimethylsulfoxide (DMSO, ≥99.0%) were obtained from Merck (Darmstadt, Germany). Drug-free serum (frozen, no additives) was purchased from Sanquin (Amsterdam, the Netherlands).
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3

Simultaneous Quantification of TKI Inhibitors

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Alectinib (free base purity [FBP] = 98%), crizotinib (FBP = 98%), erlotinib (FBP = 97%), gefitinib (FBP = 98%), crizotinib-D5 (chemical purity 97%, isotopic purity 99,2%), erlotinib-D6 (FBP = 98%) and gefitinib-D3 (chemical purity = 98%, isotopic purity = 99,7%) were purchased from Bio Connect (Huissen, The Netherlands). Methanol (ULC/MS-CC/SFC grade) was purchased from Biosolve (Valkenswaard, the Netherlands). Acetonitrile (≥99.9%), 2-propanol (≥99.8%) and dimethylsulfoxide (DMSO, ≥99.0%) were obtained from Merck (Darmstadt, Germany). Ammonium-acetate (Normapur) was purchased from VWR (Leuven, Belgium). Sodium-citrate plasma (frozen, no additives) was purchased from Sanquin (Amsterdam, the Netherlands). K2-EDTA whole blood, and subsequently, K2-EDTA plasma were obtained from volunteers.
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