Lcq advantage lc mass detector instrument

Various heterocyclic aromatic thiols 1 were commercial procured from 5A Pharmatech (China), Apichemical (China), Aldrich and ACES pharma, which were all >95% purity grade. All solvents and liquid reagents were dried in advance using standard methods and distilled before use. Substituted arenesulfenyl chlorides 2 were synthesized as described in our previous publications [21] (link), [22] (link). Synthetic methods for compounds 3′ had been reported and these parent compounds for 3-4, 3-6. 3-7, 3-8, 3-9, 3-10 and 3-11 had also been fully characterized before [21] (link). Melting points were determined using an X-4 melting apparatus and were uncorrected. ¹H NMR spectra and ¹³C NMR were obtained using a 400 MHz Varian Mercury Plus 400 spectrometer. The chemical shift values (d) for the NMR spectra were reported as parts per million (ppm), using deuterated chloroform (CDCl₃) or dimethyl sulfoxide (DMSO-d₆) as the solvent and tetramethylsilane (TMS) as an internal reference standard. Mass spectra were recorded on a Thermo Finnigan LCQ Advantage LC/mass detector instrument.