Peretinoin

Manufactured by Kowa

Sourced in Japan

Peretinoin is a laboratory equipment product manufactured by Kowa. It is a specialized device designed for use in scientific research and analysis. The core function of Peretinoin is to perform a specific laboratory task, but no further details on its intended use can be provided in an unbiased and factual manner.

Automatically generated - may contain errors

Lab products found in correlation

9 cis ra, by Merck Group (1 mentions) 13 cis ra, by Merck Group (1 mentions) Sigenome non targeting sirna pool 2, by Thermo Fisher Scientific (1 mentions)

3 protocols using peretinoin

Retinoid and Interferon Combination Protocol

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Peretinoin and IFNα-2b were kindly provided by KOWA Company, Ltd. (Tokyo, Japan). ATRA, 9-cis RA, and 13-cis RA, were purchased from Sigma-Aldrich Japan K.K. (Tokyo, Japan). Stock solutions were prepared in DMSO, and all final dilutions contained 0.5% DMSO.

Shimakami T., Honda M., Shirasaki T., Takabatake R., Liu F., Murai K., Shiomoto T., Funaki M., Yamane D., Murakami S., Lemon S.M, & Kaneko S. (2014). The Acyclic Retinoid Peretinoin Inhibits Hepatitis C Virus Replication and Infectious Virus Release in Vitro. Scientific Reports, 4, 4688.

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Modulating SPHK1 and Sp1 in Hepatocellular Carcinoma

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A mammalian expression plasmid of N-terminal myc-FLAG-tagged human SPHK1 (GenBank data base accession number NM_021972) and one encoding Sp1 under the control of cytomegalovirus promoter were purchased from OriGene (Rockville, MD). Three kinds of siRNAs targeting Sp1 (FlexiTube GeneSolution GS6667 SI#00150983, 02648065, and 02648072) were purchased from Qiagen (Hilden, Germany), as well as non-targeting siRNA (siGENOME Non-Targeting siRNA Pool #2, #D-001206-14-50) from Thermo Fisher Scientific (Waltham, MA). Peretinoin was kindly provided by Kowa Company (Aichi, Japan). Sphingosine kinase inhibitor 2 (SKI II, formally 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-phenol) was purchased from Cayman Chemical Company (CAS No 312636-16-1; Ann Arbor, MI). These compounds were dissolved in DMSO. All final dilutions contained 0.5% DMSO. DEN was purchased from Sigma-Aldrich (St. Louis, MO).

Funaki M., Kitabayashi J., Shimakami T., Nagata N., Sakai Y., Takegoshi K., Okada H., Murai K., Shirasaki T., Oyama T., Yamashita T., Ota T., Takuwa Y., Honda M, & Kaneko S. (2017). Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo. Scientific Reports, 7, 16978.

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Synthesis and Characterization of Peretinoin

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Peretinoin ( [2E,4E,6E,10E]-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, C20H30O2, molecular weight 302.46 g/mol) was supplied by Kowa Company (Aichi, Japan).

Okada H., Takabatake R., Honda M., Takegoshi K., Yamashita T., Nakamura M., Shirasaki T., Sakai Y., Shimakami T., Nagata N., Takamura T., Tanaka T, & Kaneko S. (2017). Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet. Oncotarget, 8(25), 39978-39993.

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