Stnfr 1 and 2

Manufactured by R&D Systems

STNFr-I and -II are proteins that belong to the tumor necrosis factor receptor superfamily. They are soluble receptors that can bind to and neutralize the activity of their respective ligands.

Automatically generated - may contain errors

Lab products found in correlation

Scd14 elisa, by R&D Systems (1 mentions) Scd14, by R&D Systems (1 mentions)

2 protocols using stnfr 1 and 2

Vitamin D, Bone, and Inflammatory Biomarkers

Cited 2 times

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Screening laboratories were performed at local CLIA certified laboratories. Serum samples were stored at −70°C until batched analysis at the Irving Institute Biomarkers Core at Columbia University Medical Center (New York, NY). We measured 25(OH) D₂ and D₃ by liquid chromatography tandem mass spectrometry; intact PTH (radioimmunoassay; Scantibodies, Santee, CA); N-terminal propeptide of procollagen type 1 (P1NP; RIA; IDS, Scottsdale, AZ); C-telopeptide (CTX; ELISA; IDS Scottsdale, AZ); IL-6 (ELISA; R&D Systems, Minneapolis, MN); soluble receptors of TNFα (sTNFr-I and –II; ELISA; R&D Systems, Minneapolis, MN), and soluble CD14 (sCD14, ELISA; R&D Systems, Minneapolis, MN). Inflammatory biomarkers were chosen based upon association with relevant endpoints (43 (link)-46 (link)). Except for 25(OH)D, biomarkers were measured in duplicate and values averaged for analysis.

Overton E.T., Chan E.S., Brown T.T., Tebas P., McComsey G.A., Melbourne K.M., Napoli A., Hardin W.R., Ribaudo H.J, & Yin M.T. (2015). High-Dose Vitamin D and Calcium Attenuates Bone Loss with Antiretroviral Therapy Initiation: A Prospective, Randomized Placebo-Controlled Trial for Bone Health in HIV-Infected Individuals. Annals of internal medicine, 162(12), 815-824.

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Serum Biomarker Analysis by LC-MS/MS

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Serum samples were stored at −70˚C until batched analysis at the Irving Institute Biomarkers Core at Columbia University Medical Center. We measured 25-OHD₂ and D₃ by liquid chromatography tandem mass spectrometry; intact PTH by radioimmunoassay (Scantibodies, Santee, CA); N-terminal propeptide of procollagen type 1 (P1NP; RIA; IDS, Scottsdale, AZ); C-telopeptide (CTX; ELISA; IDS Scottsdale, AZ); IL-6 (ELISA; R&D Systems, Minneapolis, MN); soluble receptors of TNFα (sTNFr-I and –II; ELISA; R&D Systems, Minneapolis, MN), and soluble CD14 (sCD14, ELISA; R&D Systems, Minneapolis, MN). Except for 25-OHD, biomarkers were measured in duplicate and values averaged for analysis.

Yin M.T., RoyChoudhury A., Bucovsky M., Colon I., Ferris D.C., Olender S., Agarwal S., Sharma A., Zeana C., Zingman B, & Shane E. (2019). A randomized placebo-controlled trial of low versus moderate dose Vitamin D3 supplementation on bone mineral density in postmenopausal women with HIV. Journal of acquired immune deficiency syndromes (1999), 80(3), 342-349.

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