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Discovery 750w 3.0t

Manufactured by GE Healthcare
Sourced in United States

The Discovery 750w 3.0T is a magnetic resonance imaging (MRI) system designed and manufactured by GE Healthcare. It is a 3.0 Tesla (T) wide-bore MRI system that provides high-quality imaging capabilities for a variety of clinical applications.

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7 protocols using discovery 750w 3.0t

1

Comprehensive MRI Imaging Protocol for Oncology

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All examinations were performed using the same 3.0 T MRI scanner (Discovery 750 W 3.0 T, GE Healthcare, Milwaukee, USA) and a 32 channel pelvic coil. The imaging protocol contained transverse T1WI, axial, sagittal, coronal T2WI, transverse DWI, and DCE. DCE‐MRI was acquired by the Liver Acquisition with Volume Acceleration (LAVA) sequence (TR/TE 2.6/1.1 ms, 3 mm section thickness, 0 mm section gap, 380 mm × 380 mm field of view, 200 × 160 matrix, 12° flip angle, 13.7 s temporal resolution, 4.6 min time of acquisition). Prior to the DCE scan, T1 mapping was acquired with a 5° and 13° flip angle. Subsequently, Gadopentetate dimeglumine injection (contrast medium, Gd‐DTPA, Beilu, China) was administered after two baseline scans through an intravenous bolus injection (0.2 ml/kg body weight) at a rate of 2.5 ml/s using a high‐pressure mechanical injector, followed by a flush of 15 ml of saline solution. The details of all imaging sequence parameters are summarized in Table S1.
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2

3T MRI Neuroimaging Protocol for Brain FLAIR Analysis

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Magnetic resonance images were acquired using a 3.0 Tesla MR scanner (Discovery 750W 3.0T, GE Healthcare, Milwaukee) with a 32-channel head coil (GE Healthcare). The imaging parameters for coronal 3D Cube FLAIR plus HyperSense sequence were: reverse order, field of view = 220 × 198mm, matrix size = 256 × 256, slice thickness = 0.9mm, slice interval: 0 mm, number of slice = 152, repetition time = 6302ms, echo time = 97.7ms, bandwidth = 150kHz, number of excitations = 1, acceleration factor = Asset2 + HS2, scan time = 2.5 minutes. The imaging parameters for coronal 2D T2WI FLAIR sequence were: reverse order, field of view=220 × 198 mm, matrix size = 256 × 256, slice thickness = 5.0mm, slice interval: 1.0mm, number of slice = 24, repetition time = 9000ms, echo time = 138.4ms, bandwidth = 31.2 kHz, number of excitations = 1, acceleration factor = Asset2, scan time = 2.5 minutes.
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3

MRI-Based Multimodal Imaging Protocol

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All recruited patients were scanned using the same model 3.0 T MRI (Discovery 750W 3.0T, GE Healthcare, Milwaukee, USA) with a 32-channel pelvic coil. The protocol included transverse T1WI; transverse, sagittal, and coronal T2WI; transverse DWI; apparent diffusion coefficient (ADC) imaging derived from DWI; and dynamic contrast-enhanced. DWI was applied with a b value of 0 s/mm2, 1000 s/mm2. The details of the imaging sequence parameters of two medical centers are summarized in Supplementary Table 1.
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4

3D-TOF and Silent MRA Imaging Protocol

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Magnetic resonance images were acquired using a 3.0 Tesla MR scanner (Discovery 750w 3.0T, GE Healthcare, Milwaukee, USA) with a 32-channel head coil (GE Healthcare). Vacuum cushions were applied to reduce the noise and movement artifact. The 3D-TOF MRA sequence was scanned in the oblique plane with the following parameters: TR = 23 ms, TE = 2.8 ms, FOV = 240 × 211 mm2, slice thickness = 1.4 mm, Matrix = 384 × 256, NEX = 0.85. The Silent MRA sequence was acquired in sagittal plane with the following parameters: TR = 826 ms, TE = 0 ms, FOV = 200 × 200 mm2, slice thickness = 1.2 mm, Matrix = 166 × 166 mm, NEX = 1. The technical details for all the MRI sequences are presented in Table 1.

Scan parameters of 3D-TOF MRA and Silent MRA

Parameters3D-TOF MRASilent MRA
Scan planeOblique planeSagittal plane
Acquisition type3-dimensional3-dimensional
TR/TE (ms)23/2.8826/0
FOV (mm2)240 × 211200 × 200
Matrix384 × 256166 × 166
Bandwidth (Hz)31.2031.20
Flip angle (°)203
Slice thickness (mm)1.41.2
NEX0.851
Acquisition time (min:s)4:166:17

TE echo time, TR repetition time, FOV field of view, NEX number of excitations, TOF time of flight, MRA magnetic resonance angiography

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5

High-Resolution Structural Brain Imaging

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All participants were scanned on a 3T Trio MRI system (GE Discovery 750w 3.0T) equipped with a 32-channel phase-array head coil. All participants were requested to remain calm, keep their eyes closed and avoid any movement during the image acquisition. Axial T1/T2-weighted images and T2 fluid attenuated inversion recovery (T2-FLAIR) images were performed to eliminate significant structural abnormalities of each subject. A high-resolution 3D fast-spoiled gradient recalled acquisition (FSPGR) sequence was acquired with the following parameters: rotation time (TR)/echo time (TE): 8.7/3.2ms, slice thickness: 1.0 mm, field of view (FOV): 256 mm × 256 mm, matrix size: 256 × 256, flip angle: 12°, slice number: 160 with no gap, and scan duration: 4 minutes 23 seconds. All sections were acquired parallel to the anterior–posterior commissure line.
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6

Rectal MRI Imaging Protocol for Radiomics

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Rectal MRI was scanned on two 3.0 T MR systems (Siemens Skyra 3.0T and GE Discovery 750w 3.0T) using a phased array coil. Before scanning, intestinal cleaning was performed by enema administration with 20 ml of glycerin. Oblique-axial high-resolution T2WI was perpendicular to the long axis of the rectum comprising the lesion. Routine sequences including sagittal T2WI, axial diffusion-weighted images (DWI, b-value: 0, 1000 s/mm2), axial T1-weighted images (T1WI), and gadolinium contrast-enhanced T1WI of the pelvis were obtained in the sagittal, coronal, and axial planes. Details on parameters applied for high-resolution T2WI, which were used for radiomics models, are shown in Supplemental Table 1.
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7

pCASL Perfusion Imaging with Susceptibility Effect

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We conducted pCASL perfusion imaging with a 3-tesla MR unit (Discovery 750w 3.0T; GE Healthcare, Chicago, IL). We used a whole-brain three-dimensional spiral fast-spin echo sequence with the following imaging parameters; eight spiral arms of 512 points each, a z-direction phase encoding value of 34, section thickness of 4 mm, TR of 5306 ms, post-labeling delay of 2.525 s, NEX 3, and total acquisition time of 5 min 8 s.
An AW Volumeshare5 workstation and a Zio Station2 were used for image processing.
For the VE-ASL to generate the susceptibility effect for the suppression of the target vessel, we used surgical staples (Precise Skin Stapler S, 3M, Two Harbors, MN, USA) which is an MR-conditional product, manufactured from nickel-chromium stainless steel (size 6.9 × 3.6 mm, weight 34.0 mg). For the experimental study, we first measured the range of the magnetic susceptibility effect obtained from the surgical staples during image acquisition when locating them nearby the cylindrical phantom (Fig. 1). Based on the relationship between the number of suture staples and the size of the susceptibility effect, we determined the appropriate number of suture staples to provide a sufficient signal saturation. Next, we assessed the degree of temperature increase around the surgical staples by monitoring a temperature seal attached to the cylindrical phantom.
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