Thalidomide was purchased from Olon S.p.A. (Milan, Italy). Phenacetin was obtained from Carlo Erba (Milan, Italy). β-cyclodextrin and hydroxypropyl-β-cyclodextrin were supplied by Roquette (Lestrem, France). Sulphobutylether-β-cyclodextrin was kindly donated by CYDEX Pharmaceuticals (Lawrence, KS, USA). Lecithin (LIPOID S45) was supplied by Lipoid AG (Steinhausen, Switzerland). HPLC-grade acetonitrile was obtained from VWR International S.r.l. (Milan, Italy). All other reagents and solvents used were analytical grade.
Hydroxypropyl β cyclodextrin
Manufactured by Roquette
Sourced in France, Switzerland
Hydroxypropyl-β-cyclodextrin is a modified cyclodextrin compound used in various laboratory applications. It is a water-soluble, cyclic oligosaccharide derivative that can form inclusion complexes with a wide range of organic and inorganic compounds. The core function of Hydroxypropyl-β-cyclodextrin is to enhance the solubility, stability, and bioavailability of guest molecules in controlled laboratory environments.
Automatically generated - may contain errors
Lab products found in correlation
β cyclodextrin, by Roquette (2 mentions)
Direct q 3uv water purifier, by Merck Group (2 mentions)
Hpβcd, by Roquette (2 mentions)
Tween 80, by Merck Group (2 mentions)
Hplc grade acetonitrile, by Avantor (1 mentions)
Lecithin s45, by Lipoid (1 mentions)
Alamarblue, by Bio-Rad (1 mentions)
Dimethyl sulfoxide (dmso), by Merck Group (1 mentions)
Phosphate buffered saline (pbs), by American Type Culture Collection (1 mentions)
Trypsin edta, by American Type Culture Collection (1 mentions)
Streptomycin, by American Type Culture Collection (1 mentions)
Tryptic soy broth (tsb), by bioMérieux (1 mentions)
Amphotericin, by American Type Culture Collection (1 mentions)
Gentamicin, by American Type Culture Collection (1 mentions)
Maxidex, by Alcon (1 mentions)
Kleptose, by Roquette (1 mentions)
Resomer rg 752h, by Merck Group (1 mentions)
Trans ferulic acid, by Merck Group (1 mentions)
Poloxamer 188, by Merck Group (1 mentions)
Polyvinyl alcohol (pva), by Daejung Chemicals (1 mentions)
8 protocols using hydroxypropyl β cyclodextrin
1
Cyclodextrin-based drug formulations
2
Detailed Characterization of Ophthalmic Formulations
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DXMa was purchased from LA COOPER (Melun, France). Hydroxypropyl-γ-cyclodextrin (HPγCD, W8HP, DS = 0.6, and Mw = 1576 Da) was a kind gift from ASHLAND (Schaffhausen, Switzerland) and hydroxypropyl-β-cyclodextrin (HPβCD, KLEPTOSE DS = 0.63 and Mw = 1391 Da) was obtained from ROQUETTE (Lestrem, France). CELLUVISC® (sodium carboxymethylcellulose) and VISMED® (sodium hyaluronate) are marketed gels used for the treatment of dry eye syndrome. DEXAFREE® (DXM sodium phosphate 1% solution eye drops), MAXIDEX® (DXM 0.1% suspension eye drops) and BSS® (Alcon Laboratories, Rueil-Malmaison, France) are human authorized ocular medicines. Normal human primary corneal epithelial cells (ATCC PCS 700-010), medium (ATCC PCS-700-030), growth kit (ATCC PCS-700-040), PBS (ATCC 30-2200), trypsin EDTA (ATCC PCS-999-003 and 005), and antibiotics (gentamicin, streptomycin, and amphotericin BATC PCS-999-002) were obtained from LGC standard - ATCC® (Molsheim, France). Thioglycollate with resazurine medium and Tryptic soy broth were obtained from BIOMERIEUX (Craponne, France). ALAMARBLUE® was purchased from BIO-RAD (Marnes-la-Coquette, France) and DMSO from SIGMA-ALDRICH (Lyon, France). Purified water was prepared by DIRECT-Q®3UV water purifier (MILLIPORE, Molsheim, France). All other solvents and chemicals were of HPLC and analytical grade, respectively.
3
Piroxicam-Cyclodextrin Inclusion Complex
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Piroxicam (PX) and low molecular weight chitosan (LMW, 150 kDa, DD 95–98%) were obtained from Sigma Aldrich (Munich, Germany). β-cyclodextrin (β-CD), methylated-β-cyclodextrin (number of methyl groups per molecule (DS) = 0.57) and hydroxypropyl-β-cyclodextrin (average number of hydroxypropyl groups per anhydroglucose unit (MS) = 0.85) KLEPTOSE® were purchased from Roquette (Lestrem, France), with MW 1135, 1191 and 1376 g/mol, respectively. All chemicals and solvents were of analytical grade.
Simulating saliva buffer (pH 6.8) was prepared using sodium chloride (0.8 g), sodium phosphate dibasic (2.38 g), and potassium phosphate monobasic (0.19 g) in 1 L of distilled water. Phosphate buffer saline (PBS) pH 7.4 was prepared by dissolving sodium chloride (8.0 g), potassium chloride (0.20 g), sodium phosphate dibasic (1.44 g), and potassium phosphate monobasic (0.24 g) in 1 L of distilled water. All components of buffer solutions were purchased from Merck (Darmstadt, Germany).
Simulating saliva buffer (pH 6.8) was prepared using sodium chloride (0.8 g), sodium phosphate dibasic (2.38 g), and potassium phosphate monobasic (0.19 g) in 1 L of distilled water. Phosphate buffer saline (PBS) pH 7.4 was prepared by dissolving sodium chloride (8.0 g), potassium chloride (0.20 g), sodium phosphate dibasic (1.44 g), and potassium phosphate monobasic (0.24 g) in 1 L of distilled water. All components of buffer solutions were purchased from Merck (Darmstadt, Germany).
4
Encapsulation of Trans-Ferulic Acid in Biodegradable Polymers
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Trans-Ferulic acid, Resomer® R 202 H, acid terminated, Mw 10.000–18.000 (PLA), Resomer® RG 752 H, acid terminated, lactide:glycolide 75:25, Mw 4.000–15.000 (PLGA), and Tween® 80 were supplied by Merck (Milan, Italy). Ethanol (96% purity) was obtained from J.T.Baker (Deventer, The Netherlands). Acetone and dialysis membrane (molecular weight cut off (Mwco) 3000 Da, diameter 11.5 mm; Spectra/Por®) were purchased from VWR International PBI Srl (Milan, Italy). Hydroxypropyl-β-cyclodextrin was obtained from Roquette Freres (Lestrem, France). Deionized water was used for all the preparations.
5
Formulation and Characterization of Diflunisal
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Diflunisal was supplied by AK Scientific (Union city, San Francisco, USA). Beta-cyclodextrin (βCD) and hydroxypropyl β-cyclodextrin (HPβCD) were provided by Roquette (Lestrem, France). Carboxymethyl cellulose sodium (CMC-Na) and Poloxamer-188 (PXM-188) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Polyvinyl alcohol (PVA) was purchased from Daejung (Siheung, Korea). All other materials were of analytical reagent grade and used as received.
6
Ultrasound-Guided Tumor Imaging and Combination Therapy
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Upon detection of a mass during weekly palpation, KPC or allograft-bearing mice were subjected to high-contrast ultrasound imaging using the Vevo 2100 System with a MS250, 13–24 MHz scanhead (Visual Sonics, Inc, Amsterdam, NL). Mice with tumour diameters of 7–9 mm were randomized and enroled one day after scanning. CR-31 was formulated in 5.2% PEG-400 (Sigma-Aldrich Cat# 1546445)/5.2% Tween80 (Sigma-Aldrich Cat#P4780) in saline. Mice were administered vehicle, 0.2 mg kg−1 CR-31 (intraperitoneal injection, daily) and/or 200 mg kg−1 CB839 formulated in 25% hydroxypropyl-β-cyclodextrin (Roquette Cat#3461111) (oral gavage, twice daily). Tumour volume was monitored on days 4 and 7 after initial scan. The same dosing regimen was applied to C57Bl/6 J mice bearing orthotopic mouse tumour allografts.
7
Butamben Formulation Development
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Butamben (BTB) (butyl-4-aminobenzoate), cholesterol (CH), l -α-phosphatidylcholine from egg yolk (PC), α-Cyclodextrin (αCD), γ-Cyclodextrin (γCD), stearylamine (SA) and sodium cholate (SC) were from Sigma-Aldrich (Milan, Italy). β-Cyclodextrin (βCD) and hydroxypropyl-β-Cyclodextrin (HPβCD), with an average substitution degree per anhydroglucose unit of 0.6), were kindly provided by Roquette (Lille, France). Hydroxypropyl-α-Cyclodextrin (HPαCD) (MS 0.6) and randomly methylated β-Cyclodextrin (RAMEB), (MS 1.8) were donated by Wacker Chemie GmbH (München, Germany). Sulfobutylether-β-Cyclodextrin (SBEβCD) (Captisol) was given as a kind gift from CyDex Inc. (Dallas, TX, USA). Carbopol® 940 (polyacrylic acid) was kindly provided by Noveon, Inc. (Cleveland, OH, USA). All other chemicals were of analytical reagent quality.
8
Formulation and Characterization of DXM Eye Drops
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DXMa was purchased from LA COOPER (Melun, France). Hydroxypropyl-γ-cyclodextrin (HPγCD, W8HP, DS = 0.6 and Mw = 1576 Da) was a kind gift from ASHLAND (Schaffhausen, Switzerland) and Hydroxypropyl-β-cyclodextrin (HPβCD, KLEPTOSE DS = 0.63 and Mw = 1391 Da) was obtained from ROQUETTE (Lestrem, France). CELLUVISC® (sodium carboxymethylcellulose), GEL LARMES® (Carbopol 974P) and VISMED® (sodium hyaluronate) are marketed gels used for the treatment of dry eye syndrome. DEXAFREE® (DXM sodium phosphate 1% solution eye drops), MAXIDEX® (DXM 0.1% suspension eye drops) are human authorized ocular medicines. Methanol (HiPerSolvCHROMANORM for HPLC grade) was purchased from BDH, PROLABO (Leuven, Belgium. Purified water was prepared by DIRECT-Q® 3UV water purifier (MILLIPORE, Molsheim, France). All other solvents and chemicals were of HPLC and analytical grade, respectively.
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