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Rb6 8c5 antibody

Manufactured by BioXCell
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The RB6-8C5 antibody is a rat monoclonal antibody that recognizes the Ly-6G antigen, which is expressed on the surface of granulocytes, including neutrophils, eosinophils, and myeloid-derived suppressor cells. This antibody can be used to detect and study these cell types in various experimental applications.

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RB6-8C5 (30 citations) Anti-Gr1 antibody (clone RB6-8C5, (4 citations) Anti-Gr1 monoclonal antibody (clone: RB6-8C5) (2 citations) Anti–mouse Gr-1 antibody (clone RB6–8C5) (2 citations)

2 protocols using rb6 8c5 antibody

1

Gr-1+ Cell Depletion for Vaginal Challenge

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Mice were depleted of Gr-1+ cells by i.p. injection of 100 μg of rat monoclonal RB6–8C5 antibody (BioXCell, West Lebanon, NH) for 3 consecutive days beginning 7 days prior to the vaginal challenge. Depletion was assessed in PBMCs via flow cytometry for Gr-1 and Ly6, with gating for the neutrophil population, one day before passive transfer.
Olczak P., Wong M., Tsai H.L., Wang H., Kirnbauer R., Griffith A.J., Lambert P.F, & Roden R.B. (2022). Vaccination with human alphapapillomavirus-derived L2 multimer protects against human betapapillomavirus challenge, including in epidermodysplasia verruciformis model mice. Virology, 575, 63-73.
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2

LCMV-WE Infection and Myeloid Cell Depletion

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LCMV-WE-infected mice were intravenously treated with RB6-8C5 antibody (Bioxcell, West Lebanon, NH, USA; 200 µg per mouse) on day 3 after LCMV infection to deplete Gr-1 + myeloid cells and to analyse viral load (by plaque assay and histological analysis), or were treated additionally on days 7 and 11 after infection for T cell measurement.
Honke N., Shaabani N., Hardt C., Krings C., Häussinger D., Lang P.A., Lang K.S, & Keitel V. (2017). Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 41(1).
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