Morantel

Manufactured by Merck Group

Sourced in United States

Morantel is a lab equipment product manufactured by Merck Group. It is designed for use in scientific research and laboratory settings. The core function of Morantel is to facilitate specific processes or measurements in a controlled and accurate manner, contributing to the advancement of scientific knowledge and discovery.

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Lab products found in correlation

4 protocols using morantel

Compound Library for In Vivo Studies

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The FDA Pharmakon compound library was purchased from MicroSource Discovery Systems, Inc. (USA). Compounds were delivered in microplates (10 mM, dissolved in DMSO) and kept at −80 °C until use. For in vivo studies, morantel, levamisole, and prasterone (DHEA) were purchased from Sigma-Aldrich (Buchs, Switzerland).
Medium RPMI 1640 was purchased from Gibco/Thermo Fisher (Waltham, MA USA), and penicillin (100 U/ml), streptomycin (100 µg/ml), and inactivated fetal calf serum (iFCS) were purchased from BioConcept (Allschwil, Switzerland).

Keiser J, & Häberli C. (2021). Assessment of FDA-approved drugs against Strongyloides ratti in vitro and in vivo to identify potentially active drugs against strongyloidiasis. Parasites & Vectors, 14, 615.

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Neurotransmitter Receptor Assay Protocol

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Levamisole, acetylcholine, pyrantel, morantel, and nicotine were obtained from Sigma Aldrich (St. Louis, MO, USA) and stock concentrations of Levamisole HCl (100 mM), pyrantel citrate (30 mM), morantel citrate (30 mM), nicotine (30 mM), and acetylcholine chloride (100 mM) were prepared in distilled water and diluted in bath solution to obtain final concentration. acetylcholine chloride was made up freshly for each days’ experiment. For motility assays, the recording solution was RPMI-1640, while for whole-cell recordings drugs were diluted in recording solution as mentioned below to obtain a final concentration.

Kashyap S.S., Verma S., McHugh M., Wolday M., Williams P.D., Robertson A.P, & Martin R.J. (2021). Anthelmintic resistance and homeostatic plasticity (Brugia malayi). Scientific Reports, 11, 14499.

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Compound Library Preparation and In Vivo Testing

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The FDA Pharmakon compound library was purchased from MicroSource Discovery Systems, Inc. (USA). Compounds (10 mM, dissolved in DMSO) were stored at -80 °C until use. Levamisole and ivermectin, used for the in vitro controls, were purchased from Fluka and Sigma-Aldrich, respectively (Buchs, Switzerland), dissolved at 10 mM stock solutions in DMSO, and stored at -20 °C until further use. For the in vivo studies, bitoscanate, chlorcyclizine HCl, clemastine, dicyclomine HCl, drofenine HCl, ethopropazine HCl, lansoprazole, metformin HCl, morantel, natamycin, trichlorfon, and trimipramine maleate were purchased from Sigma-Aldrich.

Keiser J., Panic G., Adelfio R., Cowan N., Vargas M, & Scandale I. (2016). Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections. Parasites & Vectors, 9, 376.

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Pharmacological Assessment of Neuroprotective Agents

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Carvacrol, morantel, pyrantel, bephenium, and GABA were obtained from Sigma-Aldrich Co (St Louis, MO, USA). morantel, pyrantel, bephenium, and GABA were dissolved in the APF-Ringer, while Carvacrol was dissolved in ethanol, with the final concentration of ethanol in the APF-Ringer of 0.1%v/v. When tested, 0.1% of ethanol did not alter the resting activity of preparations and did not alter the drug responses.

Marjanović D.S., Trailović S.M, & Milovanović M. (2021). Interaction of agonists of a different subtype of the nAChR and carvacrol with GABA in Ascaris suum somatic muscle contractions. Journal of Nematology, 53, e2021-22.

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