6 lauroyl 2 dimethylaminonaphthalene laurdan

Manufactured by Thermo Fisher Scientific

Sourced in United States

6-lauroyl-2-dimethylaminonaphthalene (Laurdan) is a fluorescent probe commonly used in the study of lipid membranes and cellular environments. It functions as a polarity-sensitive dye, exhibiting changes in its emission spectrum in response to the polarity of its surrounding environment.

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Lab products found in correlation

1 2 dioleoyl sn glycero 3 phosphocholine, by Avanti Polar Lipids (1 mentions) 1 2 dioleoyl sn glycero 3 phospho l serine, by Avanti Polar Lipids (1 mentions) 1 palmitoyl 2 oleoyl sn glycero 3 phospho 1 rac glycerol, by Avanti Polar Lipids (1 mentions) 1 palmitoyl 2 oleoyl sn glycero 3 phosphoethanolamine, by Avanti Polar Lipids (1 mentions) 5 6 carboxyfluorescein cf, by Merck Group (1 mentions) 1 2 dioleoyl sn glycero 3 phosphoglycerol, by Avanti Polar Lipids (1 mentions) 1 2 dipalmitoyl sn glycero 3 phosphoethanolamine n 7 nitro 2 1 3 benzoxadiazol 4 yl, by Avanti Polar Lipids (1 mentions)

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Laurdan (54 citations)

2 protocols using 6 lauroyl 2 dimethylaminonaphthalene laurdan

Lipid Membrane Characterization via Fluorescent Probes

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1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), 1,2-dilauroyl-sn-glycero-3-phospho-L-serine (DLPS), and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DOPE-PEG2000) were supplied by Avanti Polar Lipids, Inc. (Alabaster, USA). 6-lauroyl-2-dimethylaminonaphthalene (Laurdan) was obtained from Molecular Probes (Eugene, USA). 4-[(n-dodecylthio)methyl]-7-(N,N-dimethylamino)-coumarin (Dtmac) was a gift of prof. Kraayenhof, Vrije Universiteit Amsterdam. CaCl₂ with purity ≥99% was used. All chemicals were used without further purification.

Melcrová A., Pokorna S., Pullanchery S., Kohagen M., Jurkiewicz P., Hof M., Jungwirth P., Cremer P.S, & Cwiklik L. (2016). The complex nature of calcium cation interactions with phospholipid bilayers. Scientific Reports, 6, 38035.

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Probing Lipid Membrane Interactions with Fluorescent Peptides

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5(6)-carboxyfluorescein (CF) and CL-2B Sepharose were from Sigma (St. Louis, MO). 6-lauroyl-2-dimethylamino naphthalene (Laurdan) was from Molecular Probes (Invitrogen, Eugene, OR). 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), 1-palmitoyl-2-oleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (POPG), 1’,3’-bis[1,2-dioleoyl-sn-glycero-3-phospho]-glycerol (Cardiolipin, TOCL), 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2–1,3-benzoxadiazol-4-yl) (DPPE-NBD), and 1-lauroyl-2-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine (Pyr-PC) were from Avanti Polar Lipids (Alabaster, AL). Peptides (horine: WWWLRRRW and verine-L: RRRWWWWL) were chemically synthesized and purified > 95% (Genemed Synthesis, TX). Some calculated properties of these peptides are given in Table S1. All reagents were used as received.

Bozelli JC J.r., Yune J., Dang X., Narayana J.L., Wang G, & Epand R.M. (2020). Membrane activity of two short Trp-rich amphipathic peptides. Biochimica et biophysica acta. Biomembranes, 1862(7), 183280.

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