Discovery vct pet ct

Manufactured by GE Healthcare

Sourced in United States

The Discovery VCT PET/CT is a combined positron emission tomography (PET) and computed tomography (CT) imaging system designed for medical diagnosis and research. It provides both functional and anatomical information by capturing images of the body's biological processes and physical structure. The system utilizes advanced data acquisition and image reconstruction technologies to generate high-quality images for clinical applications.

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Lab products found in correlation

Discovery mi, by GE Healthcare (1 mentions) Syngo via, by Siemens (1 mentions) Biograph 64, by Siemens (1 mentions) 18f fdg, by GE Healthcare (1 mentions)

Close spelling variants of this product

Discovery VCT PET/CT system Discovery VCT PET/CT scanner Discovery VCT 690 PET/CT Discovery RX VCT 64 PET-CT device GE Discovery VCT PET/CT scanner Discovery RX VCT 64 PET-CT scanner General Electric Discovery VCT 64-slice PET/CT scanner Discovery VCT 64 PET/CT system Discovery RX VCT 64 PET-CT GE Discovery VCT PET-CT set

7 protocols using discovery vct pet ct

FDG-PET/CT Imaging and Metabolic Tumor Analysis

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All patients underwent FDG-PET/CT imaging according to institutional standard procedures after fasting for 6–8 h. FDG was administered intravenously as a bolus (mean ± SD dose 284 ± 70 MBq), and PET image acquisition started ~50 min after injection and covered the area between the eyebrows and the kidneys. At Turku University Hospital, Discovery MI (Scanner A) and Discovery VCT PET/CT (Scanner C) (General Electric Healthcare, Milwaukee, WI, USA) were used, and at Helsinki Discovery, MI (Scanner B) and Siemens Biograph 64 (Scanner D) (Siemens Healthineers, Malvern, PA, USA) were used. The sinogram data were corrected for dead time, decay, and photon attenuation and were reconstructed in a 256 × 256 matrix.
Image analyses were performed using the General Electric AW Server 3.2 and Siemens Syngo.via software by two experienced nuclear medicine physicians (M.S. and J.S.) blinded to the patient genomic data. The maximum and mean standardized uptake values (SUVmax and SUVmean) were determined for primary tumors and metastases and solely for primary tumors, respectively. The total metabolic tumor volume (MTV) was determined using 50% of SUVmax as a threshold, and total lesion glycolysis (TLG) was calculated as a product of SUVmean and MTV [24 (link)].

Silvoniemi A., Laine J., Aro K., Nissi L., Bäck L., Schildt J., Hirvonen J., Hagström J., Irjala H., Aaltonen L.M., Seppänen M, & Minn H. (2023). Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma: Association with Metabolic Tumor Burden Determined with FDG-PET/CT. Cancers, 15(15), 3970.

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Whole-Body PET/CT Imaging with 18F-FDG

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A combined ¹⁸F-FDG PET/ CT scanner (General Electric Discovery VCT PET/CT, Waukesha, WI) was used to perform whole body imaging. Images were interpreted according to standard methods. Whole-body CT covers a region ranging from the head to the mid-thigh. After fasting for at least four hours, patients received an intravenous injection of ¹⁸F-FDG [10–20 mCi]. Blood glucose was checked in all patients before performing ¹⁸F-FDG PET/CT and no patient had a blood glucose level >160 mg/dl. About 50 minutes later, CT scanning was conducted and whole-body emission PET scanning was performed. Attenuation-corrected PET images were reconstructed with an iterative reconstruction algorithm. ¹⁸F-FDG PET/CT images were generated for review on a workstation.

Chang G.H., Kurzrock R., Tran L., Schwaederle M, & Hoh C.K. (2018). TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [18F] fluorodeoxyglucose (18F-FDG PET). Oncotarget, 9(18), 14306-14310.

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Cardiac PET/CT Imaging Protocol

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PET was performed 40-60 minutes after the administration of 18F-FDG at a dose of 3.7-5.5 MBq/kg using a Discovery VCT PET/CT (GE Healthcare, Waukesha, WI, USA) under conditions of the 12H-F or F-HFD protocol. The heart was localized using CT Scout imaging and PET/CT scanning using 1 PET bed width (15 cm) and taking the heart as the center. CT was performed first with using the following parameters: a tube voltage of 120 kV, a tube current of 30 mA, and layers of 5 mm in height. Next, an electrocardiography-gated three-dimensional model was used to perform PET data collection (8 time phases per cardiac cycle). The data acquisition time was 10 min (matrix, 128 × 28; iterative reconstruction, 2; 20 subsets; half-height weight, 6 mm). CT data from the same scanner were used for attenuation correction, image reconstruction and merging of the PET image.

Yan R., Song J., Wu Z., Guo M., Liu J., Li J., Hao X, & Li S. (2015). Detection of Myocardial Metabolic Abnormalities by 18F-FDG PET/CT and Corresponding Pathological Changes in Beagles with Local Heart Irradiation. Korean Journal of Radiology, 16(4), 919-928.

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Dual-Tracer PET/CT Imaging Protocol for Neuroreceptor Assessment

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Prior to the ¹¹C-CFT PET/CT scan, patients were required to undergo a 12-h withdrawal of the medication to avoid the interference to the binding capacity of DAT. Sixty minutes after intravenous injection of ¹¹C-CFT (185–370 MBq), a CT and a 15-min PET scan in three-dimensional mode were acquired using a Discovery VCT PET/CT (GE Healthcare, Milwaukee WI, United States). CT acquisition was done with 140 kVp and 200 mAs, which was used for attenuation correction and localization of the lesion site. CT slice thickness was set to the same slice thickness of PET imaging (3.75 mm). For PET imaging, the FORE-Iterative reconstruction algorithm with 20 subsets, 2 iterations, and 2.14 mm (full width at half maximum) post-filtering was used.
¹⁸F-FDG PET/CT scanning was performed on a different day before or after the ¹¹C-CFT PET/CT scanning within 2 weeks. All participants fasted for at least 6 h and stopped any drugs that could affect brain metabolism for at least 12 h before the ¹⁸F-FDG PET/CT acquisition. An ¹⁸F-FDG dose of 0.1 mCi/kg (3.7 MBq/kg) was intravenously injected after ensuring the blood glucose level was ≤200 mg/L. The participants rested in a quiet and dimly lit room before and after the ¹⁸F-FDG injection until the start of imaging. The settings of the image acquisition and data reconstruction were similar to those of the ¹¹C-CFT PET/CT scan.

Sun X., Liu F., Liu Q., Gai Y., Ruan W., Wimalarathne D.N., Hu F., Tan X, & Lan X. (2019). Quantitative Research of 11C-CFT and 18F-FDG PET in Parkinson’s Disease: A Pilot Study With NeuroQ Software. Frontiers in Neuroscience, 13, 299.

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PSMA PET/CT Imaging Protocol for PCa

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All patient examinations were performed according to PCa PSMA PET/CT imaging Guidelines (EANM Guidelines/SNMMI Procedure Standard 2.0). The ¹⁸F-PSMA-1007 PET/CT examination was performed by an experienced nuclear medicine technician licensed to work with large equipment. The study employed a GE Discovery VCT PET-CT (64-row CT) scanner, and the equipment was qualified for quality control. The ¹⁸F-PSMA-1007 was synthesized using PET-IFB-X5 (Shaanxi Zhengze Biotechnology Co., Ltd.). The purity of ¹⁸F-PSMA-1007 was assessed using high-performance liquid chromatography, yielding a result of ≥95%.The injected ¹⁸F-PSMA-1007 was 4.0 MBq/kg. A whole-body scan was performed approximately 60–90 min after injection, followed by a spiral CT scan ranging from the cranial roof to the middle femur.
The scanning parameters included a tube voltage of 140 kV, tube current of 150 mA, layer thickness of 3.75 mm, pitch of 0.875, and matrix size of 512 × 512. PET scans were conducted using a three-dimensional mode, employing a matrix of 128 × 128, and allocating 2.5 minutes per bed. The total number of beds scanned ranged from 7 to 9. CT data were utilized to correct for attenuation in the PET images, followed by image reconstruction and fusion.

Li Y., Chen J., Wang X., Yang P., Yang J., Zhao Q, & Li J. (2024). Predictive value of volumetric parameters based on 18F-PSMA-1007 PET/CT for prostate cancer metastasis. Frontiers in Oncology, 14, 1335205.

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Standardized PET/CT Imaging Protocol

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All patients underwent PET/CT whole-body scanning two weeks before treatment. The scanner and tracer were Discovery VCT PET/CT (GE Healthcare, Waukesha, WI, USA) and ¹⁸F-FDG, respectively; the radiochemical purity was > 95%. Patients were prohibited from strenuous exercise within 24 hours before examination and fasted for at least 6 hours to ensure their blood glucose level was < 11.1 mmol/L. After quiet rest for 60 ± 10 minutes, 5.5 MBq/kg FDG was injected intravenously, and the scan was performed. The scanning range was from the skull base to the lower femur. CT scanning parameters were as follows: tube voltage, 120 kVp; tube current, 110 mA; and slice thickness, 3.75 mm. The emission scan was acquired for 2 minutes per bed position. Images of four to six bed positions were acquired for each patient, and PET images were reconstructed using an ordered subset expectation maximization algorithm.

Luo Y., Huang Z., Gao Z., Wang B., Zhang Y., Bai Y., Wu Q, & Wang M. (2024). Prognostic Value of 18F-FDG PET/CT Radiomics in Extranodal Nasal-Type NK/T Cell Lymphoma. Korean Journal of Radiology, 25(2), 189-198.

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Multimodal Imaging and Therapy Protocol

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Computer tomography was done with 64-row CT routine scanning configured by Discovery VCT PET/CT (GE, USA). Required particle implantation instruments, including implantation guns and push thimbles were produced by Zhejiang Xiangshan, and puncture needles were 15-20 cm × 18 G (Hakko, Japan). Radiotherapy treatment planning system (TPS) system was provided by Zhuhai Hejia Medical Equipment Co. (HGGR-2000 version). Particle source was supplied by Beijing Atomic Hi-Tech Co., Ltd., with particle diameter of 0.8 mm and length of 4.5 mm. The shell was titanium metal fully closed, and the particle activity was between 0.4-0.8 mCi, with half-life of 60 days. Particles were sterilized by high temperature using high pressure steam sterilization method. Serum squamous cell carcinoma-associated antigen (SCC-Ag) detection was determined by chemiluminescence (Shenzhen New Industry Biological Co.) Serum carcinoembryonic antigen (CEA) was measured with chemiluminescence (Soling-LIAISON chemiluminescence instrument, kit provided by Soling-LIAISON, reference range of 0-5 ng/ml).

Ji L., Zhang W., Hao S., Wang Z, & Zhang G. (2023). Clinical efficacy analysis of radioactive 125I particle implantation for the treatment of pelvic local recurrence of cervical cancer after radiotherapy. Journal of Contemporary Brachytherapy, 15(6), 432-441.

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