The following chemicals were used: diazepam (J.S.C. «Organica», Novokuznetsk, Russia), phenazepam (FSBI “Zakusov Institute of Pharmacology”, Moscow, Russia), pentobarbital sodium salt (FSBI “Zakusov Institute of Pharmacology”, Moscow, Russia), pentylenetetrazole (Sigma Aldrich, Burlington, MA, USA), polysorbate-80 (tween-80) (Sigma Aldrich, USA), polyethylene glycol 400 (Sigma-Aldrich, Burlington, MA, USA), BD-1047 hydrobromide (Tocris Bioscience, Bristol, UK), NE-100 hydrochloride (Santa Cruz Biotechnology, Dallas, TX, USA), [N-methyl-3H] flunitrazepam (Amersham, UK), BD-1047 hydrobromide (Tocris Bioscience, Bristol, UK), NE-100 hydrochloride (Santa Cruz Biotechnology, Dallas, TX, USA), Tris(hydroxymethyl)aminomethane (Sigma-Aldrich, Burlington, MA, USA), sucrose (Sigma-Aldrich, Burlington, MA, USA), 1,4-dioxane (Ecos-1, Moscow, Russia), naphthalene (Sigma-Aldrich, Burlington, MA, USA), 2,5-diphenyloxazole (Sigma-Aldrich, Burlington, MA, USA), and 1,4-Bis(5-phenyl-2-oxazolyl)benzene (Sigma Aldrich, Burlington, MA, USA).
Polysorbate 80 tween 80
Manufactured by Merck Group
Sourced in United States, Germany, Spain, France, India
Polysorbate 80 (Tween 80) is a nonionic surfactant commonly used as an emulsifier, solubilizer, and dispersant in various pharmaceutical, cosmetic, and food applications. It is a viscous, pale yellow liquid with a mild odor. Polysorbate 80 acts as a wetting agent and can improve the solubility and dispersion of other ingredients in formulations.
Automatically generated - may contain errors
Lab products found in correlation
Acetonitrile, by Merck Group (6 mentions)
Dimethyl sulfoxide (dmso), by Merck Group (5 mentions)
Propylene glycol, by Merck Group (3 mentions)
Cholesterol, by Merck Group (3 mentions)
Methanol, by Merck Group (3 mentions)
Milli q system, by Merck Group (3 mentions)
Polyethylene glycol 400, by Merck Group (2 mentions)
Sucrose, by Merck Group (2 mentions)
Curcumin, by Merck Group (2 mentions)
Sorbitan monostearate span 60, by Merck Group (2 mentions)
Chloroform, by Merck Group (2 mentions)
Ketoconazole, by MedChemExpress (2 mentions)
Corn oil, by Merck Group (2 mentions)
Anti btk, by Cell Signaling Technology (2 mentions)
Fvb wild type mice, by Taconic Biosciences (2 mentions)
Peg300, by Merck Group (2 mentions)
Cobicistat, by MedChemExpress (2 mentions)
Peg400, by Merck Group (2 mentions)
Span 80, by Merck Group (2 mentions)
Ethanol, by Merck Group (2 mentions)
53 protocols using polysorbate 80 tween 80
1
Pharmacological Evaluation of Anxiolytic Agents
2
Formulation of Infliximab Antibody
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The following materials were used: sucrose (Sigma-Aldrich), polysorbate 80 (Tween 80, Sigma-Aldrich), inulin (4kD; Sensus, Roosendaal), dextran (5kD; Pharmacosmos Denmark), sodium dihydrogen phosphate (Sigma-Aldrich), disodium hydrogen phosphate (Sigma-Aldrich) and 5 mg/mL of Infliximab antibody bulk (5 mg/ml in 5% sucrose and 0.005% (polysorbate 80, pH 7.2) (obtained from AIMM therapeutics).
3
HPLC Quantification of Prodrug CZ48 and Metabolite CPT
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CZ44 (Figure 1C ), CPT-20-O-acetate, was used as the internal standard for HPLC assay that simultaneously quantifies the prodrug CZ48 and its active metabolite, CPT.20 (link) CZ48 (purity of 98%) and CZ44 were provided by CHRISTUS Stehlin Foundation for Cancer Research (Houston, TX, USA) as gifts; CPT was purchased from Sigma-Aldrich (St. Louis, MO, USA). Pluronic® F 68 (F-68) and Pluronic® F108 (F-108) were kindly provided by BASF (BASF corporation, NJ, USA); KH2PO4, K2HPO4, NaCl, povidone 40 (PVP 40), polyvinyl acetate (PVA), polyethylene glycol 400, and polysorbate 80 (Tween-80) were purchased from Sigma-Aldrich. Double-distilled water was produced by a Millipore Milli-Q system (Billerica, MA, USA). HPLC-grade acetic acid, dimethyl sulfoxide, acetonitrile, dichloromethane, ethanol and diethyl ether were purchased from Sigma-Aldrich. CZ48 cosolvent was prepared as dimethyl sulfoxide:polyethylene glycol 400:ethanol (2:2:1 by volume).
4
Conductive PEDOT:PSS Aqueous Dispersion
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A high-conductivity, surfactant-free, aqueous dispersion of PEDOT:PSS (1.2 wt%) and polysorbate 80 (Tween 80) were obtained from Sigma-Aldrich (Gillingham, UK). All materials were used as received.
5
Piperlongumine Formulation Development
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Piperlongumine was supplied by Research Products International (Mt. Prospect, IL, USA). HPLC grade acetonitrile (ACN) was obtained from Spectrum Chemical Manufacturing (Gardena, CA, USA). USP grade ethanol was obtained from Decon Laboratories Inc. (King of Prussia, PA US). Cremophor Rh 40 was obtained from BASF Aktiengesellschaft, (Ludwigshafen, Germany). Sulfobutyl ether β-cyclodextrin sodium salt research grade (Captisol®) was obtained from CyDex Inc. (Lenexa, Kansas, USA). Hydroxypropyl-β-cyclodextrin (Cavasol®) was obtained from Wacker Chemie AG (Burghausen, Germany). Polyethylene glycol 400, propylene glycol, glycerin, polysorbate 80 (Tween 80), n-octanol, ascorbic acid, ethylenediaminetetraacetic acid (EDTA) disodium salt, sodium bisulfite, monopotassium phosphate, disodium phosphate, disodium citrate and boric acid were obtained from Sigma Aldrich (St. Louis, MO, USA). Phosphate buffered saline was obtained from Amresco, Inc. (Solon, OH, USA).
6
Atrazine Formulation Development
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Poly(epsilon-caprolactone) - PCL, atrazine, polysorbate 80 (Tween 80), sorbitan monostearate surfactant (Span 60), and xylenol orange were purchased from Sigma-Aldrich. Thiobarbituric acid was obtained from MP Biomedicals. A commercial atrazine formulation (Gesaprim 500 CG) was obtained from Syngenta. Other reagents (analytical grade or better) were purchased from local suppliers.
7
Dissolution Protocol for Small Molecule Inhibitors
8
Polysiloxane-Based Ceramic Composites
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Commercial methyl polysiloxane (Silres® MK, Wacker Chemie AG, Burghausen, Germany) and phenylmethyl polysiloxane (Silres® H44, Wacker Chemie) were used as the binders and preceramic polymer. Xylene (98.5%, Sigma–Aldrich, Hamburg, Germany) was the solvent for the polysiloxanes and the liquid medium, which was used to further disperse the components, and imidazole (99%, Imidazole) was applied as a cross-linking catalyst. Commercially available silicon carbide (SiC F800, d = 6.5 μm, Fluka) and titanium dioxide (TiO2, d = 21 nm, P25 Degussa) particles were incorporated as fillers. Azodicarbonamide (ADA, 97%, Sigma–Aldrich) was used as the pore former. Methylene blue (MB, Fluka) was used as a tracer dye. MCT oil was used to prepare an oil-in-water emulsion, and Polysorbate 80 (Tween 80, Sigma–Aldrich) was applied as a surfactant.
9
Curcumin-Based Therapeutic Formulation
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Curcumin, polysorbate 80 (tween-80), Vitamin E Succinate, disodium hydrogen orthophosphate, sodium chloride, monobasic potassium phosphate, dimethyl sulfoxide (DMSO), 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), 2′,7′-dichlorodihydrofluorescein diacetate (H2DCFDA), and Triton X-100 were purchased from Sigma-Aldrich (St. Louis, MO, USA). PEG-600 was purchased from Beantown chemicals (BTC, Hudson, NH, USA), ethyl oleate from Acros organics (Geel, Belgium), hydrochloric acid from Merck Germany, and cellulose dialysis membrane from Spectrum Labs VWR Scientific (Radnor, PA, USA). The Dulbecco’s modified Eagle’s medium (DMEM), penicillin−streptomycin (PS) solution 100×, and trypsin−ethylenediaminetetraacetic acid were purchased from Invitrogen Corp. (Carlsbad, CA, USA). Fetal bovine serum (FBS) and Hank’s balanced salt solution (HBSS) were purchased from Mediatech (Manassas, VA, USA), and streptozotocin (STZ) was purchased from AG Scientific (San Diego, CA, USA). All chemicals were used without any further purification.
10
Colchicine Nanoparticle Formulation Development
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Colchicine was procured from Sigma-Aldrich Co. (St Louis, MO, USA). Poly ethylene glycol- distearoylphosphatidyl ethanolamine (DSPE-PEG 2000) was purchased from Lipoid LLC, (Newark, NJ, USA). Cholesterol, non-ionic surfactant (Sorbitan Monostearate; Span 60 and polysorbate 80; Tween 80), chloroform, and sodium alginate were purchased from Sigma-Aldrich Co. (St Louis, MO, USA). Jojoba oil was obtained from NOW® Essential Oils (NOW Foods, Bloomingdale, IL, USA). All other solvents and chemicals of analytical grade were purchased from Sigma, USA.
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