Deltatrac metabolic monitor

Manufactured by Cardinal Health

The Deltatrac Metabolic Monitor is a laboratory equipment used to measure and analyze a patient's metabolic rate. It provides accurate and reliable data on oxygen consumption and carbon dioxide production, which are essential parameters for evaluating an individual's energy expenditure and metabolic processes.

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Lab products found in correlation

Quarkrmr metabolic monitor, by Cosmed (1 mentions) Vmax encore, by Cardinal Health (1 mentions) Quark rmr, by Cosmed (1 mentions) Quark rmr, by Cardinal Health (1 mentions) Vmax encore, by BD (1 mentions)

5 protocols using deltatrac metabolic monitor

Metabolic Assessments via Hyperinsulinemic Clamp

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All participants were admitted to the PCTCR and underwent a hyperinsulinemic-euglycemic clamp combined with stable isotope tracers and continuous indirect calorimetry after a 10- to 12-hour overnight fast. Fasting blood samples were obtained for determination of lipid profile, adiponectin and HbA1c. Before the start of the hyperinsulinemic-euglycemic clamp, fasting hepatic glucose production was measured with a primed (2.2 μmol/kg) constant infusion of [6,6-²H₂]glucose at 0.22 μmol/kg/min for 2 hours as published (34 (link)). Whole-body lipolysis was measured at baseline and during the hyperinsulinemic-euglycemic clamp with a primed (1.2 umol/kg) constant-rate infusion of [²H₅]glycerol (MSD Isotopes, St. Louis, MO), which was started 2 hours before the clamp (35 (link),36 (link)). Following the 2-hour baseline isotope infusion period, in vivo insulin sensitivity was assessed during a 3-hour hyperinsulinemic (80 mu/m²/min)-euglycemic (100 mg/dL) clamp. Continuous indirect calorimetry (Deltatrac Metabolic Monitor; SensorMedics, Anaheim, CA) was used to measure CO₂ production, O₂ consumption, and RQ for 30 min at baseline and at the end of the euglycemic clamp (13 (link)).

Gebara N.Y., Kim J.Y., Bacha F., Lee S, & Arslanian S. (2021). Metabolic Inflexibility in Youth with Obesity: Is it a Feature of Obesity or Distinctive of Youth Who are Metabolically Unhealthy?. Clinical obesity, 12(2), e12501.

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Comprehensive Metabolic Assessment Protocol

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Details of metabolic studies and biochemical measurements (glucose, insulin, FFA, lipids, HbA_1c, and enrichments of glycerol and glucose) are described in the Supplementary Data. In brief, all participants underwent a hyperinsulinemic-euglycemic clamp combined with stable isotopes and continuous indirect calorimetry and a hyperglycemic clamp after 10–12 h of fasting within a 1–4-week period in random order (2 (link),3 (link)). Fasting hepatic glucose production (HGP) was measured by [6,6-²H₂]glucose and whole-body lipolysis by [²H₅]glycerol as before (10 (link)). Peripheral IS was evaluated during a 3-h hyperinsulinemic (80 mU/m²/min)-euglycemic clamp (2 (link)–4 (link)). Substrate oxidation was measured by continuous indirect calorimetry (Deltatrac Metabolic Monitor; SensorMedics, Anaheim, CA) as previously described (10 (link)). First- and second-phase insulin secretion were assessed during a 2-h hyperglycemic (225 mg/dL) clamp (2 (link)–4 (link)). Glucose tolerance status was determined with HbA_1c and/or a 2-h oral glucose tolerance test (OGTT; 1.75 g/kg, maximum 75 g) (11 (link)). Fasting blood samples were obtained for lipid profile.

Kim J.Y., Nasr A., Tfayli H., Bacha F., Michaliszyn S.F, & Arslanian S. (2017). Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity, and Impaired β-Cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth With Impaired Glucose Tolerance. Diabetes, 66(12), 3085-3090.

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Validating QuarkRMR Metabolic Monitor

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A form of “N-of-1” methodology (6 (link),7 (link)) was used to validate the QuarkRMR^® metabolic monitor (Cosmed, Rome, Italy) against a criterion method, the Deltatrac^® Metabolic Monitor (Sensormedics, Yorba Linda, CA). The intent was to repeatedly test both devices in a single subject in order to both define and minimize biological variation, thereby focusing on variation due to the devices. The current study was approved by the institutional review board at our institution. Informed consent was obtained from the subject.

Ashcraft C.M, & Frankenfield D.C. (2014). A test of validity of a new open-circuit indirect calorimeter. JPEN. Journal of parenteral and enteral nutrition, 39(6), 738-742.

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Validated Indirect Calorimetry for Energy Expenditure

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Energy expenditure was measured by IC using the Quark RMR® (Cosmed, Rome, Italy) at both RU and PS-HMC and the Vmax® Encore (CareFusion, Yorba Linda, California) metabolic cart at CWRU. For the purposes of this study, the Quark RMR® (newer IC device) was validated against the criterion standard, Deltatrac Metabolic Monitor (Sensormedics, Yorba Linda, CA), and was found to be of suitable precision for measuring REE.²¹ The Vmax® Encore and the Quark RMR were also tested for reliability, and were found to be comparable devices.^{35 (link)} Additional details of the reliability testing completed have been reported previously.^{34 (link)} The IC measurements were completed in accordance to evidence-based practice guidelines,^{18 (link)} and were instituted and followed at each research institution in order to minimize measurement error.^{35 (link)} The 5-minute steady state protocol followed the methodology published by Olejnik et al (2016).^{34 (link)} To calculate mREE, we used the Weir equation:^{36 (link)}

mREE = ([(3.94 * {VO}_{2}) + (1.11 * {VCO}_{2})] * 1.44) (10)

Byham-Gray L.D., Parrott J.S., Peters E.N., Fogerite S.G., Hand R.K., Ahrens S., Marcus A.F, & Fiutem J.J. (2017). MODELING A PREDICTIVE ENERGY EQUATION SPECIFIC FOR MAINTENANCE HEMODIALYSIS. JPEN. Journal of parenteral and enteral nutrition, 42(3), 587-596.

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Standardized Basal Metabolic Rate Measurement

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Basal metabolic rate was always measured in the postabsorptive state using calorimetry with ventilated hood (DeltaTrac Metabolic Monitor, Sensor Medics, Yorba Linda, CA). The calibration of these metabolic carts was standardized as previously reported [22 (link)]. In brief, the metabolic carts were calibrated each morning and underwent extra quality control including monthly pressure and gas calibrations together with biannual alcohol burn test calibrations. The test-retest difference is <3% for duplicate measures of VO₂ for adults in the same environment on sequential days using our instruments. In addition, each day we first check the calibration with a known gas mixture and if the variance from the known is >1.25% the instrument is reset. We also measure VO₂ and CO₂ monthly in one of our personnel; if the O₂ consumption rate is >20 ml/min different from average, we re-measure that person with another instrument to test for biological versus instrument issues.
All volunteers were admitted to the Mayo General Clinical Research Center (GCRC) in the evening prior to the study day and consumed their evening meal at the same, standardized time (1800 h). They then spent the night in the GCRC in order to assure the indirect calorimetry was performed before rising out of bed the next morning and before any food consumption. The BMR was performed typically between 0700 and 0800 h.

Anthanont P., Levine J.A., McCrady-Spitzer S.K, & Jensen M.D. (2016). Lack of Seasonal Differences in Basal Metabolic Rate in Humans – a Cross-Sectional Study. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 49(1), 30-35.

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