Magnetom symphony 1.5 tesla

Two different MR scanners, the Siemens MAGNETOM Aera 1.5 Tesla and the Siemens MAGNETOM Symphony 1.5 Tesla were used. Experienced pediatric radiologists reviewed the MRI scans. All scans were presented and discussed in institutional tumor board meetings.

MRI was performed on a Magnetom Symphony 1.5-tesla (Siemens, Erlangen, Germany). High spatial resolution, 3-dimensional (3D) T1-weighted images, diffusion tensor imaging (DTI), conventional T2-weighted images, and fluid attenuation inversion recovery images of the brain were obtained for the morphometric study. Detailed information on MRI parameters are described elsewhere43 (link). On conventional MRI, no abnormal findings were detected in the brain of any subject. Each individual 3D-T1 image was normalized with the diffeomorphic anatomical registration using exponentiated lie (DARTEL) registration method44 (link) using Statistical Parametric Mapping 8 (Wellcome Trust, University College London, UK) software. DTI metrics were calculated by using Tract-Based Spatial Statistics (TBSS) analysis45 (link). A fractional anisotropy (FA) threshold of 0.20 or higher was set to exclude peripheral tracts. Evaluation of the leukoaraiosis was performed on T2-weighted images using Fazekas Scale by a single person (M.O.) in a blinded manner46 (link).