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5 amino 1 pentanol

Manufactured by Merck Group
Sourced in United States

5-amino-1-pentanol is a chemical compound that serves as a building block for various pharmaceutical and industrial applications. It is a primary alcohol with an amino group attached to the fifth carbon position. This versatile compound can be utilized in the synthesis of other chemicals and materials, though its specific applications should be evaluated by the customer based on their needs and requirements.

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6 protocols using 5 amino 1 pentanol

1

Multisection Soft Pneumatic Actuator

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The rigid section paste was prepared by mixing 3.0 g of polydimethylsiloxane (PDMS, 10:1 mixture of a prepolymer: curing agent, Sylgard 184, Dow Corning, Midland, MI, USA), 4.5 g of glass fiber (GF) (milled fiber glass 50 um, Fiberman, Burnaby, BC, Canada), and 0.3 g of hexane (Daejung Chemicals & Materials Co., Siheung-si, Gyeonggi-do, Korea) using a Thinky Mixer (ARE-310, Japan) for 3 min, deformed for 1 min, and then mixed for 1 min. The intermediate section paste was prepared by mixing high-viscosity PDMS (10:1 mixture of a prepolymer:curing agent, Sylgard 186, Dow Corning) using a Thinky Mixer for 3 min, deformed for 1 min, and then mixed for 1 min. The soft section solution was prepared by mixing PDMS (20:1, Sylgard 184) and a reverse-micelle-induced (RMI) solution. First, a solution for the aqueous core of the RMI was prepared by stirring 1.0 mL of ethanol (95%, Samchun Chemical) and 0.1 g of 5-amino-1-pentanol (95%, Sigma-Aldrich, St. Louis, MO, USA) [22 (link)]. Then, 0.1 mL of the solution was mixed with 5.0 mL of octane (95%, Samchun Chemical Co., Seoul, Korea) and 1.0 mL of 1-octanol (99%, Sigma-Aldrich). Finally, 1.5 mL of the RMI solution was mixed with 10.0 g of PDMS (20:1, Sylgard 184).
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2

Synthesis and Purification of Polycationic Polymer PbAE

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The PbAE (MW ~4 kDa) was synthesized in a two-step reaction procedure as previously described (23 (link)). In the first step, the base polymer was synthesized by mixing 1,4-butanediol diacrylate (Sigma-Aldrich) with 5-amino-1-pentanol (Sigma-Aldrich) at a molar ratio of 1.2:1. The reaction was maintained at 90°C for 24 hours in a glass scintillating vial with a teflon stir bar. The base polymer was dried, and then dissolved in anhydrous dimethyl sulfoxide (DMSO) at a final concentration of 167 mg/mL. In the second step, 480 μL of the base polymer solution was mixed with 320 μL of 0.5 mol/L (PEO)4-bis-amine (Molecular Biosciences, Boulder, CO) in a 1.5-mL Eppendorf tube, and the reaction was allowed for 24 hours at room temperature. The polymer mix was first dialyzed against milli-Q water in a dialysis tube (MWCO 3,500 Da) to remove the bulk of free reagents, and then mixed with 4× the volume of ethyl ether (Sigma-Aldrich) and vortexed vigorously followed by centrifugation at 4,000 rpm for 5 minutes to further remove unreacted monomers in the supernatant. The purified polymers were vacuum-dried and then dissolved in 25 mM sodium acetate, pH 5.2.
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3

Synthesis of Functionalized Polymers

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HA (98%), acetic anhydride
(≥98%), 5-amino-1-pentanol (≥92%), acrylic acid (99%),
K2CO3 (≥99%), N-(3-(dimethylamino)propyl)-N′-ethylcarbodiimide hydrochloride (98%), N,N-diisopropylethylamine (>99%), benzyl
methacrylate (96%), copper(II) chloride (99.999%), tris[2-(dimethylamino)ethyl]amine, ethylene bis(2-bromoisobutyrate) (97%),
tin(II) 2-ethylhexanoate (92.5–100%), and anisole (≥99.7%)
were purchased from Sigma-Aldrich and used as received. Methanol (Certified
ACS), ethyl acetate (Certified ACS), hexanes (Certified ACS), dichloromethane
(Certified ACS), diethyl ether (Certified ACS), dimethylformamide
(Certified ACS), tetrahydrofuran (THF, Certified ACS), and THF (HPLC)
were purchased from Fisher and used as received.
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4

Evaluation of Cell Viability Assays

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5-Amino-1-pentanol, 6-aminocaproic acid, 1-aminohexane, and N, N'-Hexamethylenebisacrylamide (HMBA) were purchased from Sigma-Aldrich. Plerixafor was obtained from BioChemPartner, Shang Hai, China. Polyethyleneimine (PEI) Mw 10 kDa was from Polyscience, Pennsylvania, USA. Cy3-NHS was from Lumiprobe. APC-labeled anti-CXCR4, and IgG isotype were from BD Bioscience, CA, USA. RPMI-1640 medium and fetal bovine serum (FBS) were obtained from Hyclone, USA. CellTiter-Blue reagent was purchased from Promega. Mouse tubular epithelial cells (MCT) and human tubular cells (HK-2) were kind gifts from Dr. Padanilam.
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5

Multifunctional Silica Nanoparticle Synthesis

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Dimethyl
sulfoxide (DMSO, 99.9%), toluene
(99.5%), and hexane (98.5%) were purchased from BDH. Anhydrous toluene
(99.8%), Reagent Plus acetone (≥99%), Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene
glycol) (Pluronic P123, average Mn ∼5800),
tetraethyl orthosilicate (TEOS, 99.0%), N,N-diisopropylethylamine (DIPEA, 99.9%), hydrochloric acid
(37 wt %), ethanolamine (>98%), 5-amino-1-pentanol (95%), and 4-nitrobenzaldehyde
(4-NB, 98%) were obtained from Sigma Aldrich. (3-Aminopropyl)trimethoxysilane
(IPTMS, 97%), ammonium hydroxide (28 wt % in H2O), 3-amino-1-propanol
(99%), and 4-amino-1-butanol (98%) were acquired from Alfa Aesar.
1,4-Dimethoxybenzene (DMB, >99%) was produced by Tokyo Chemical
Industry
(TCI), and ethanol (99.5%) was produced by VMR Koptec.
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6

Synthesis of Metal Chalcogenide Nanostructures

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Zinc acetate dihydrate (99%), indium (III) acetylacetonate (99.99%), N,Ndimethyl formamide (DMF, 99.9%), 5-Amino-1-Pentanol (AP, 95%), thioacetamide (99%), oleylamine (OLA, 70%), ammonium sulfide (40-48% in water) and chloroform (99.5%) were supplied by Sigma-Aldrich. Acetone (99%) was purchased from Chem Supply. n-hexane (95%) was supplied by Univar. All chemicals were used without further purification.
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