Desiccated, killed mycobacterium tuberculosis H37Ra was obtained from Bioscientific Pty Ltd. Complete Freund’s adjuvant (CFA) was purchased from Sigma-Aldrich (MO, USA). Myelin oligodendrocyte glycoprotein (MOG35-55; amino acid [10 ] sequence: H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH) and pertussis toxin were obtained from Sapphire Biosciences. Interchangeable syringes were obtained from Cadence Inc (VA, USA). 1-Methyl-DL-tryptophan (Sigma-Aldrich, MO, USA) was diluted in 5N HCl and adjusted to pH 7 before injection [11 (link)]. Ro 61-8048 (Tocris, Bristol, UK) was dissolved in DMSO and diluted in sterile 0.9% saline to a concentration of 10 mg/ml, and the pH was adjusted to 7.5 [12 (link)].
Ro 61 8048
Manufactured by Bio-Techne
Sourced in United Kingdom, United States
Ro 61-8048 is a laboratory chemical compound used in research applications. It serves as a selective antagonist for the CB1 cannabinoid receptor. The core function of Ro 61-8048 is to inhibit the activity of the CB1 receptor, which is involved in various physiological processes.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using ro 61 8048
1
Induction of Experimental Autoimmune Encephalomyelitis
2
Synthesis and Characterization of Ro 61-8048 and PNU-120596
Check if the same lab product or an alternative is used in the 5 most similar protocols
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Ro 61‐8048 (3,4‐dimethoxy‐[‐N‐4‐(nitrophenyl)thiazol‐2‐yl]‐benzenesulfonamide; PubChem CID: 5282337) and PNU‐120596 (PubChem CID: 311434) were purchased from Tocris (USA; Catalogue nos. 3254 and 2498/5, respectively). L‐leucine (PubChem CID: 6106) was obtained from Fisher Scientific (USA; Catalogue no. BP385‐100). Pyrazole (PubChem CID: 1048), probenecid (PubChem CID: 4911) and L‐KYN sulfate salt (PubChem CID: 161165) were purchased from Sigma‐Aldrich (Merck, Germany; Catalogue nos. P56607, P8761 and K3750, respectively). Absolute ethanol and HPLC‐grade acetonitrile and methanol were obtained from Panreac AppliChem (Panreac Química, Spain, Catalogue nos. 141086, 361881 and 361091, respectively). Other chemicals were of analytical grade and obtained from Sigma‐Aldrich (Merck, Germany).
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