Naproxen

Manufactured by Cayman Chemical

Sourced in United States

Naproxen is a chemical compound used as a reference standard in analytical laboratory settings. It is a non-steroidal anti-inflammatory drug (NSAID) that can be used to verify the identity and purity of related pharmaceutical products. Naproxen is provided as a solid material in various formats to support analytical testing and quality control procedures.

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Lab products found in correlation

Etodolac, by Cayman Chemical (1 mentions) Ketoprofen, by Cayman Chemical (1 mentions) Lps l2880, by Merck Group (1 mentions) Ketoprofen, by Merck Group (1 mentions) Sodium arsenite, by Merck Group (1 mentions) Sulforaphane, by Cayman Chemical (1 mentions) Indomethacin, by Merck Group (1 mentions) Ibuprofen, by Cayman Chemical (1 mentions) Aspirin, by Cayman Chemical (1 mentions) Celecoxib, by Cayman Chemical (1 mentions) Celltiter glo reagent, by Promega (1 mentions) Acetonitrile, by Merck Group (1 mentions) Kollidon va64, by BASF (1 mentions) Trifluoroacetic acid, by Merck Group (1 mentions) Venetoclax, by Abbvie (1 mentions)

3 protocols using naproxen

Anti-inflammatory Compound Screening in Macrophages

Cited 1 time

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BMDMs were treated with with 0.125 – 0.5 mM indomethacin (Sigma-Aldrich), 0.25 – 1 mM (S)-ibuprofen (Cayman Chemical), 0.125 – 0.5 mM ketoprofen (Sigma-Aldrich), 0.25 – 1 mM Etodolac (Cayman Chemical), or 0.25 – 1 mM naproxen (Cayman Chemical), 0.25–1 mM rofecoxib, 5 mM sulforaphane (Cayman Chemical), 100 μM dimethylfumarate. NSAIDs were diluted in 1% DMSO. Cells were pretreated with NSAID for 1 hour prior to stimulation with 10 ng/mL LPS (L2880, Sigma-Aldrich). LDH assay performed according to manufacturer’s instructions (601170, Cayman Chemical). Reactive oxygen species (ROS) measured using H2DCFDA (D399, ThermoFisher) as described previously (Kavian et al., 2018 (link)). Sodium arsenite (Sigma-Aldrich), naphthalenedione (DMNQ, Cayman Chemical) and phenazine methosulfate (PMS, Cayman Chemical) at the indicated doses were used to induce ROS in BMDM.
MDMs were treated with indicated concentrations of indomethacin (Sigma-Aldrich), ketoprofen (Cayman Chemical), or sulforaphane (Cayman Chemical) for indicated durations.

Eisenstein A., Hilliard B.K., Pope S.D., Zhang C., Taskar P., Waizman D.A., Israni-Winger K., Tian H., Luan H.H, & Wang A. (2022). Activation of the transcription factor NRF2 mediates the anti-inflammatory and tissue protective properties of a subset of over-the-counter and prescription NSAIDs. Immunity, 55(6), 1082-1095.e5.

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Caco-2 Cell Viability Assay for C. difficile

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Caco-2 cells were plated in black 96-well plates at 3 × 10⁴ cells per well and incubated for 48 hours. After 48 hours, cell culture medium was refreshed, and cells were treated with indomethacin, ibuprofen (Cayman), naproxen (Cayman), aspirin, R2PPA, valeroyl silyciate (Cayman), celecoxib (Cayman), PGE₂ (Cayman), or vehicle control [dimethyl sulfoxide (DMSO)] for 16 hours overnight. The next day, cells were intoxicated with filter-sterilized C. difficile VPI10463 cultures at a final dilution of 1:5 or 1:15 or mock-infected (BHI) and incubated for 8 hours. Cell viability was indicated by measuring ATP levels using the CellTiter Glo Reagent (Promega). Data were normalized to ATP levels of vehicle-treated and mock-infected cells.

Soto Ocaña J., Bayard N.U., Hart J.L., Thomas A.K., Furth E.E., Lacy D.B., Aronoff D.M, & Zackular J.P. (2023). Nonsteroidal anti-inflammatory drugs sensitize epithelial cells to Clostridioides difficile toxin–mediated mitochondrial damage. Science Advances, 9(29), eadh5552.

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Naproxen and Venetoclax Dissolution Study

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Naproxen was supplied by Cayman Chemical (Ann Arbor, MI, USA), and venetoclax was obtained from AbbVie Inc. (Chicago, IL, USA). Vinylpyrrolidone-vinyl acetate copolymer (PVPVA64, Kollidon^® VA 64) was purchased from BASF SE (Ludwigshafen, Germany). Methanol, water (LS-MS Grade), trifluoroacetic acid, and acetonitrile were purchased from Merck KGaA (Darmstadt, Germany). For the dissolution experiments, purified water without buffer was used. Unbuffered water was chosen because the modeling calculations in Section 2 were performed using water without any buffer system.

Dohrn S., Kyeremateng S.O., Bochmann E., Sobich E., Wahl A., Liepold B., Sadowski G, & Degenhardt M. (2023). Thermodynamic Modeling of the Amorphous Solid Dispersion-Water Interfacial Layer and Its Impact on the Release Mechanism. Pharmaceutics, 15(5), 1539.

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