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Gadoteridol

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Gadoteridol is a contrast agent used in magnetic resonance imaging (MRI) procedures. It is a paramagnetic, gadolinium-based compound that enhances the visibility of certain structures and organs within the body during MRI scans.

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Lab products found in correlation

Prohance, by Bracco (4 mentions) Hypersense dissolution dnp system, by Oxford Instruments (3 mentions) 1 13c pyruvic acid, by Cambridge Isotopes (3 mentions) Creatine, by Bracco (2 mentions) Trizma ph 7, by Merck Group (2 mentions) 1h 13c dual tunedvolume coil, by Bruker (2 mentions) Ox063, by GE Healthcare (2 mentions) Matlab, by MathWorks (1 mentions) Avanto fit, by Siemens (1 mentions) Sprague dawley rat, by Charles River Laboratories (1 mentions) Achieva, by Philips (1 mentions) Ox063, by Oxford Instruments (1 mentions) 11.7 t mri scanner, by Bruker (1 mentions) Fluent 12, by ANSYS (1 mentions)

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ProHance” gadoteridol (6 citations)

19 protocols using gadoteridol

1

Rat Brain Perfusion and Imaging

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All animal procedures were approved by the Duke IACUC. Male Wistar rats weighing 345–374 gm were purchased from Jackson Laboratories. The weight of the animal from which the single brain atlas was generated was 345.6 gm. The average atlas was generated from six specimens with mean weight (± SD) of 361.0 ± 7.5 gm. Brains were perfused using the active staining protocol described previously (Johnson et al., 2012 (link); Johnson and Hedlund, 2000 ; Johnson et al., 2002 (link)). Briefly, the brain was perfused in situ with a mixture of buffered formalin and 10% Prohance (Gadoteridol; Bracco Diagnostics Inc., Monroe Twp., NJ, USA). The head was removed and placed in buffered formalin for 24 hrs. The intact skull was moved to a 0.5% Prohance/normal saline solution to rehydrate the tissue. Tissue was allowed to equilibrate for at least three weeks prior to imaging. The brain was imaged in the skull.
Allan Johnson G., Laoprasert R., Anderson R.J., Cofer G., Cook J., Pratson F, & White L.E. (2021). A multicontrast MR atlas of the Wistar rat brain. NeuroImage, 242, 118470.
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2

Rat Brain Perfusion and Imaging

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All animal procedures were approved by the Duke IACUC. Male Wistar rats weighing 345–374 gm were purchased from Jackson Laboratories. The weight of the animal from which the single brain atlas was generated was 345.6 gm. The average atlas was generated from six specimens with mean weight (± SD) of 361.0 ± 7.5 gm. Brains were perfused using the active staining protocol described previously (Johnson et al., 2012 (link); Johnson and Hedlund, 2000 ; Johnson et al., 2002 (link)). Briefly, the brain was perfused in situ with a mixture of buffered formalin and 10% Prohance (Gadoteridol; Bracco Diagnostics Inc., Monroe Twp., NJ, USA). The head was removed and placed in buffered formalin for 24 hrs. The intact skull was moved to a 0.5% Prohance/normal saline solution to rehydrate the tissue. Tissue was allowed to equilibrate for at least three weeks prior to imaging. The brain was imaged in the skull.
Allan Johnson G., Laoprasert R., Anderson R.J., Cofer G., Cook J., Pratson F, & White L.E. (2021). A multicontrast MR atlas of the Wistar rat brain. NeuroImage, 242, 118470.
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3

Cardiac MRI Protocol for Gadolinium-Enhanced Imaging

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Images were acquired on a 3 T scanner (Philips Achieva, Philips Medical Systems, Best, the Netherlands) using a six-element phased-array receiver coil. Steady-state free-precession cine images were acquired in multiple short-axis and three long-axis views (repetition time, 3.0 ms; echo time, 1.5 ms; flip angle, 40°; slice thickness 6 mm). Short-axis views were obtained every 1 cm to cover the entire left ventricle. Gadolinium contrast (0.15 mmol/kg gadoteridol, Bracco Diagnostics) was administered and delayed enhancement CMR (DE-CMR) was performed 10-15 min later with a 2D segmented gradient echo phase-sensitive inversion-recovery sequence in the same views used for cine-CMR. Inversion delay times were typically 280 to 360 ms
Rangarajan V., Chacko S.J., Romano S., Jue J., Jariwala N., Chung J, & Farzaneh-Far A. (2016). Left ventricular long axis function assessed during cine-cardiovascular magnetic resonance is an independent predictor of adverse cardiac events. Journal of Cardiovascular Magnetic Resonance, 18, 35.
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4

Transcardial Perfusion Fixation for Brain Imaging

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Mice (adult male C57BL/6) were provided with free access to food and water before experiments. Mice were anesthetized with isoflurane, a midline abdominal incision was made, and a catheter was inserted into the heart. Transcardial perfusion fixation was used with inflow to the left ventricle and outflow from the right atrium. The animals were perfused with saline and 0.1% heparin followed by a solution of 2.5 mM ProHance (Gadoteridol, Bracco Diagnostics Inc., Princeton, NJ) in 10% formalin. Both saline and ProHance-formalin were perfused at 8 ml/min for 5 min using a perfusion pump. Brain specimens were immersed in ProHance-formalin overnight and then immersed in solution of 2.5 mM ProHance in 10 mM phosphate buffered saline the next day. Imaging was obtained several weeks later. The study was approved by the local Institutional Animal Care & Use Committee.
Wei H., Xie L., Dibb R., Li W., Decker K., Zhang Y., Johnson G.A, & Liu C. (2016). Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping. NeuroImage, 137, 107-115.
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5

Optimizing 3D TSE Sequence for CSF Imaging

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Bloch simulations (instead of the analytical form in Eq. [1]) were performed to calculate the MR signal evolution during the 3D TSE readout, and compare signals in different types of brain tissues before and after Gd injection. In-house code programmed in Matlab (MathWorks, Natick, MA, USA) were used for the simulations. Table 1 summarizes the literature values for the parameters used in the simulations (references in the table captions). The relaxation times of CSF after Gd injection were calculated based on the relaxivity values r1 and r2 for the Gd contrast medium Prohance (or Gadoteridol; Bracco S.p.A., Milan, Italy; 0.5 mmol/ml) used in this study with a standard dosage of 0.1 mmol/kg. The concentration of Gd in blood was assumed to be 1 mmol/L for a typical healthy human subject (estimated from the Gd dosage, a body weight of 100kg and a total blood volume of 5L). The concentration of Gd in CSF was assumed to be 0.2 mmol/L, one fifth of that in blood (a rough estimate due to lack of literature, which will be measured with the proposed method in this study). A second simulation was performed with varying Gd concentrations in CSF to investigate its effects on the MR signals. The goal of the simulations is to find an optimal sequence with minimal blood signal and sufficient contrast for CSF before and after Gd injection.
Cao D., Kang N., Pillai J.J., Miao X., Paez A., Xu X., Xu J., Li X., Qin Q., Van Zijl P.C., Barker P, & Hua J. (2020). Fast whole brain MR imaging of dynamic susceptibility contrast changes in the CSF (cDSC MRI). Magnetic resonance in medicine, 84(6), 3256-3270.
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6

High-field MRI Contrast Imaging

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MRI scans were performed on a 3 Tesla (3T) and a 7 Tesla (7T) Philips human MRI scanner (Philips Healthcare, Best, The Netherlands). On 3T, a 32-channel phased-array head coil was used for signal reception and a dual-channel body coil for transmit. On 7T, a 32-channel phased-array head coil (Nova Medical, Wilmington, MA) was used for signal reception and an 8-channel head-only coil for transmit. The Gd contrast agent (Prohance, or Gadoteridol; Bracco S.p.A., Milan, Italy) was administered intravenously (i.v.) using a standard procedure (dosage=0.1mmol/kg, injection rate=5mL/s).
Cao D., Kang N., Pillai J.J., Miao X., Paez A., Xu X., Xu J., Li X., Qin Q., Van Zijl P.C., Barker P, & Hua J. (2020). Fast whole brain MR imaging of dynamic susceptibility contrast changes in the CSF (cDSC MRI). Magnetic resonance in medicine, 84(6), 3256-3270.
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7

Comprehensive Cardiac MRI Protocol

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All CMR exams were acquired on a 1.5 T Scanner (AvantoFit, Siemens, Erlangen, Germany) with ECG-gating and a 32-channel phased-array surface coil. For biventricular function assessment, balanced steady-state free precession cine images were acquired in four long-axis views including a four-, two-, three-chamber view as well as an RV view and one short-axis (SAX) stack, covering the entire ventricle without a gap. Parametric T2 and T1 mapping were acquired in multiple SAX slices covering the entire ventricle. T2-mapping acquisition was based on a motion-corrected balanced steady-state free precession sequence. Native T1 mapping was based on a motion-corrected modified Look-Locker inversion recovery technique using a 5-3-3 scheme. Synthetic extracellular volume was calculated from T1 mapping pre- and post-contrast media application based on a prototype sequence in basal and mid-ventricular slices. LGE imaging was acquired by a phase-sensitive inversion recovery sequence, 10–15 min after the application of 0.2 mmol/kg of contrast media (Gadoteridol, Prohance, Bracco Imaging, Konstanz, Germany). LGE images were acquired in the same axis as the cine images. FU scans were carried out using the same protocol with the exception of a subgroup of patients not receiving contrast media (N = 27). The details about the sequence parameters are given in the Supplemental Material E1.
Gröschel J., Grassow L., van Dijck P., Bhoyroo Y., Blaszczyk E, & Schulz-Menger J. (2024). Trajectories of functional and structural myocardial parameters in post-COVID-19 syndrome—insights from mid-term follow-up by cardiovascular magnetic resonance. Frontiers in Cardiovascular Medicine, 11, 1357349.
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8

Formalin and ProHance Staining for High-SNR MRI

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All animal procedures and experiments were approved by the Duke University Institutional Animal Care and Use Committee. An adult male Sprague Dawley rat (age 80 days, weight 397.6 grams, Charles River, Wilmington, MA, USA) was actively stained with a mixture of formalin and ProHance (Gadoteridol, Bracco Diagnostics, Inc., Princeton, NJ) to increase MRI signal to noise ratio while preserving the tissue (Johnson et al., 2002 (link)). The animal was anaesthetized by intraperitoneal injection of a mixture of Nembutal (Ovation Pharmaceuticals, Inc., Lake Forest, IL) and butorphanol, and transcardially perfused with 0.9% saline and ProHance (10:1 v:v) for 4 minutes followed by a flush of ProHance in 10% phosphate buffered formalin (1:10 v:v). The head with the brain in situ within the cranium was removed and stored in buffered formalin for at least 24 hours. Tissue was rehydrated by immersion in a 1:200 solution of ProHance/saline for 72 hours. The head was trimmed to fit into an acrylic sample holder that fits in the RF coil, and surrounded by fomblin, a perfluorocarbon that minimizes susceptibility artifacts at the interface.
Papp E.A., Leergaard T.B., Calabrese E., Johnson G.A, & Bjaalie J.G. (2014). Waxholm Space atlas of the Sprague Dawley rat brain. NeuroImage, 97, 374-386.
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9

Dynamic Contrast-Enhanced MRI Liver Protocol

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All patients were imaged with a single 3T MR scanner (Philips Achieva, Philips Medical Systems, Best, Netherlands). A torso phased array coil was placed around the upper abdomen of each patient. All images were acquired in axial planes. Prior to DCE-MRI, T1 weighted imaging at three different flip angles (5°, 10°, and 15°) was performed for T1 mapping [21 ]. A three-dimensional (3D) fast spoiled gradient echo sequence (THRIVE) with fat suppression was employed with the following parameters: TR/TE = 5/2.3 ms, FOV = 400 × 400 mm, NEX = 1, thickness/gap = 6/0 mm, 10 slices, frequency/phase encoding = 192/154, matrix size = 256 × 256, and SENSE factor = 2. Temporal resolution was 2.1 seconds, and imaging at each flip angle was conducted at maximum inhalation. DCE-MRI was applied for patients using the same imaging sequence and parameters, but with a fixed flip angle (FA = 15°). DCE-MRI was continued for 4.2 minutes (120 imaging). Each patient was instructed to stop breathing at maximum inhalation and repeat it as needed during DCE-MRI. The duration of each breath hold was about 20 seconds. At 30 seconds after starting DCE-MRI, gadoteridol (0.1 mmol/kg; Bracco Diagnostics Inc., Princeton, NJ) was intravenously infused at the rate of 2 ml/sec and followed by 20-ml saline flush.
Kim H, & Morgan D.E. (2017). Semiautomatic determination of arterial input function in DCE-MRI of the abdomen. Journal of biomedical engineering and medical imaging, 4(2), 96-104.
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10

Dual-pH Creatine Agarose Gel Phantom

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We prepared a dual-pH creatine agarose gel phantom. Briefly, 1% (w/w) low-melt temperature agarose was added to deionized water, heated to boiling and then immersed in a water bath set at 50°C. After the temperature settles, creatine and gadoteridol (Bracco Diagnostics, Monroe Township, NJ) were added into the solution and reach concentrations of 50 mM and 30 μM, respectively. The solution pH was titrated to 6.5 and 6.0 and transferred to two separate compartments of a dual pH phantom holder. The phantom solidified at room temperature before MRI.
, & Sun P.Z. (2019). Development of intravoxel inhomogeneity correction for chemical exchange saturation transfer (CEST) spectral imaging – A high-resolution field map-based deconvolution algorithm for magnetic field inhomogeneity correction. Magnetic resonance in medicine, 83(4), 1348-1355.
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