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Polytetrahydrofuran

Manufactured by Merck Group

Polytetrahydrofuran is a synthetic polymer that is commonly used as a raw material in the production of various laboratory equipment. It is a colorless, odorless, and viscous liquid with a high molecular weight. Polytetrahydrofuran is known for its chemical stability, flexibility, and compatibility with a wide range of solvents and materials, making it a versatile component in the manufacturing of laboratory equipment.

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4 protocols using polytetrahydrofuran

1

Synthesis of Polyurethane Containing Dopamine

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Analytical grade polytetrahydrofuran (PTMEG, Mn ≈ 2000), isophorone diisocyanate (IPDI), dimethyl formamide (DMF), dimethylol propionic acid (DMPA), dibutyltin dilaurate (DBTDL), dopamine hydrochloride, ferric chloride, and triethylamine (TEA) were purchased from Sigma-Aldrich and used as received without further purification. Hydroxyl-terminated hyperbranched polyester (n(–OH) = 12, Mn ≈ 1250) was purchased from Wuhan Hyperbranched Polymer Science & Technology Co., Ltd, China. PTMEG was dehydrated at 100 °C under vacuum for more than 24 h in advance.
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2

Synthesis of IPDI-based Polyurethane

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Isophorone diisocyanate (IPDI) was purchased from Acros Organics. N,N-dimethylformamide (DMF) was acquired from Fisher Scientific. Polytetrahydrofuran (PTHF) (Mn = 250) and dibuyltin dilaurate (DBTDL) were purchased from Sigma-Aldrich Co. Traces of moisture were removed from PTHF drying at 65 °C in under vacuum for 24 h. All other chemicals were used as received.
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3

Synthesis of PTHF-Based Photopolymer

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Polytetrahydrofuran with an average molecular mass of 2900 g/mol (PTHF2900), 2-ethylhexyl acrylate (2-EHA), methacrylic anhydride (MAA), as well as 2,6-di-tert-butyl-cresol (BHT) were purchased from Sigma Aldrich (Vienna, Austria) and used without further purification. 2,4,6-Trimethylbenzoylphenyl phosphinate (Omnirad TPO-L) was provided by IGM Resins (Walwijk, The Netherlands).
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4

Fabrication of Porous PU Mass Transfer Devices

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The PU (polyurethane) mass transfer device was fabricated by a salt leaching/phase inversion method based on our previous study [33 (link), 34 ]. The procedure is as follows: a PU solution of 25% (w/v) was prepared by dissolving PU pellets (Tecflex® SG-85A, Lubrizol, Wickliffe, OH) in N,N-dimethyl formamide (DMF; Sigma-Aldrich, St. Louis, Mo). Sodium chloride (NaCl; Sigma-Aldrich) crystals were ground and sieved to select sizes smaller than 70 μm and were mixed with the PU solution at 9/1 (NaCl/PU) weight ratios. Polytetrahydrofuran (Sigma-Aldrich) was also added to the NaCl-PU mixture in 25% (v/v) volume ratio as a soluble filler to enhance the interconnectivity of the porous scaffolds. The mixed solution was well stirred and then injected into glass cylinder molds. Porous PU scaffolds were formed by submerging the cylinder molds in 65% of ethanol with 1% DMF via phase inversion for 48 hours. After separating from the molds, the porous PU scaffolds were rinsed in distilled water for 24 hours in order to remove NaCl crystals. After the rinsing step, the porous PU scaffolds (diameter: 2.5 mm, long: 25 mm) were preserved in PBS and utilized as mass transfer devices for the further experiments. The device length of 25 mm was chosen because of sufficient length (8 mm) in NP region and better manipulation during the insertion procedure.
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